{"id":8541,"date":"2013-06-07T00:00:00","date_gmt":"2013-06-06T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2013\/06\/07\/identifiquen-una-proteina-clau-en-el-manteniment-de-la-identitat-dels-limfocits-b\/"},"modified":"2021-12-01T16:05:55","modified_gmt":"2021-12-01T15:05:55","slug":"identifiquen-una-proteina-clau-en-el-manteniment-de-la-identitat-dels-limfocits-b","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2013\/06\/identifiquen-una-proteina-clau-en-el-manteniment-de-la-identitat-dels-limfocits-b\/","title":{"rendered":"Identifiquen una prote\u00efna clau en el manteniment de la identitat dels limf\u00f2cits B"},"content":{"rendered":"<p><span class=\"TexteNivell4\">Els resultats de l\u2019estudi, publicat a PLoS Genet<\/span>ics, demostren que HDAC7 s\u2019expressa de manera espec\u00edfica en limf\u00f2cits B i no ho fa en c\u00e8l\u00b7lules d\u2019altres llinatges com per exemple els macr\u00f2fags.<\/p>\n<p><strong>Sistema hematopo\u00e8tic<\/strong><\/p>\n<p>Les c\u00e8l\u00b7lules mare de la sang passen per un sistema molt complex de diferenciaci\u00f3 per formar les diferents c\u00e8l\u00b7lules sangu\u00ednies. En el sistema hematopo\u00e8tic existeixen dues l\u00ednies principals: la limfoide, que acaba donant lloc a les c\u00e8l\u00b7lules T, els limf\u00f2cits B i les c\u00e8l\u00b7lules NK, entre d\u2019altres, i la mieloide que formar\u00e0 els eritr\u00f2cits (gl\u00f2buls vermells) o els macr\u00f2fags entre d\u2019altres.<\/p>\n<p>Segons ha explicat Maribel Parra, per tal que es donin aquests passos s\u2019han de produir una s\u00e8rie de canvis en el programa g\u00e8nic de les c\u00e8l\u00b7lules. Existeixen factors de transcripci\u00f3 que activen gens de cada llinatge cel\u00b7lular per\u00f2 tamb\u00e9 existeixen repressors transcripcionals que impedeixen que s\u2019expressin gens \u201cinapropiats\u201d, que s\u00f3n caracter\u00edstics d\u2019un altre llinatge.<\/p>\n<p>El grup Maribel Parra estudia precisament el paper d\u2019una fam\u00edlia de prote\u00efnes que s\u00f3n repressores transcripcionals en la diferenciaci\u00f3 de les c\u00e8l\u00b7lules del sistema hematopo\u00e8tic. Es tracta de les histones desacetilases (HDACs).<\/p>\n<p><strong>Repressi\u00f3 de gens \u2018inapropiats\u2019<\/strong><\/p>\n<p>En aquest treball els investigadors demostren que el paper d\u2019una d\u2019aquestes prote\u00efnes, l\u2019HDAC7, en limf\u00f2cits B \u00e9s reprimir gens \u2018inapropiats\u2019, caracter\u00edstics d\u2019altres llinatges com els macr\u00f2fags. Els investigadors van reprogramar c\u00e8l\u00b7lules precursores de limf\u00f2cits B a macr\u00f2fags (del llinatge mieloide) i van observar que l\u2019expressi\u00f3 d\u2019HDAC7 disminu\u00efa de forma dr\u00e0stica mentre que quan es torna a expressar aquesta prote\u00efna es bloqueja la inducci\u00f3 de gens clau per a la biologia dels macr\u00f2fags .<\/p>\n<p>Parra ha explicat que \u201ca trav\u00e9s d\u2019aquets mecanisme de repressi\u00f3 transcripcional, la c\u00e8l\u00b7lula B s\u2019assegura que no s\u2019expressin gens d\u2019altres tipus cel\u00b7lulars, mantenint la seva identitat limfoide\u201d. Tamb\u00e9 assenyala que \u201cdonada la seva import\u00e0ncia en la biologia dels limf\u00f2cits B, la funci\u00f3 d\u2019HDAC7 podria estar alterada en malalties hematol\u00f2giques com les leuc\u00e8mies i els limfomes. Cap aquesta hip\u00f2tesi es dirigeix ara la recerca del nostre grup\u201d.<strong><br \/>\n<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Els resultats de l\u2019estudi, publicat a PLoS Genetics, demostren que HDAC7 s\u2019expressa de manera espec\u00edfica en limf\u00f2cits B i no ho fa en c\u00e8l\u00b7lules d\u2019altres llinatges com per exemple els macr\u00f2fags. Sistema hematopo\u00e8tic Les c\u00e8l\u00b7lules mare de la sang passen per un sistema molt complex de diferenciaci\u00f3 per formar les diferents c\u00e8l\u00b7lules sangu\u00ednies. En el [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":19915,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,332],"tags":[],"class_list":["post-8541","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar","category-cancer"],"publishpress_future_action":{"enabled":false,"date":"2024-12-26 00:43:46","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8541"}],"version-history":[{"count":3,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8541\/revisions"}],"predecessor-version":[{"id":19918,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8541\/revisions\/19918"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/19915"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}