Les c\u00e8l\u00b7lules sanes viuen en un delicat equilibri entre els gens que promouen el creixement (oncogens) i els que el frenen (antioncogens o gens supressors tumorals). Aquest equilibri es trenca en les c\u00e8l\u00b7lules tumorals. Les causes en s\u00f3n moltes, com per exemple, l\u2019exist\u00e8ncia de mutacions, per\u00f2 destaca l\u2019adquisici\u00f3 d\u2019un senyal qu\u00edmic, la metilaci\u00f3, que bloqueja l\u2019activitat dels gens que frenen el c\u00e0ncer. Es desconeix, per\u00f2, qu\u00e8 succeeix a les c\u00e8l\u00b7lules un cop han adquirit aquesta alteraci\u00f3 epigen\u00e8tica.<\/p>\n
Investigadors de l\u2019IDIBELL, liderats per Manel Esteller, director del Programa d\u2019Epigen\u00e8tica i Biologia del c\u00e0ncer, investigador ICREA i professor de la Universitat de Barcelona, descriuen a l\u2019edici\u00f3 electr\u00f2nica de la revista Oncogene com aquesta metilaci\u00f3 desencadena un canvi tridimensional en el nucli de la c\u00e8l\u00b7lula formant unes estructures esf\u00e8riques anomenades nucleosomes que bloquegen la funci\u00f3 dels gens antitumorals.<\/p>\n
Els investigadors van observar que gens protectors de c\u00e0ncer com el receptor de la vitamina A veien alterada la seva activitat en c\u00e8l\u00b7lules de c\u00e0ncer de c\u00f2lon per la pres\u00e8ncia d\u2019aquestes estructures esf\u00e8riques formades per ADN (en aquest cas regions reguladores de l\u2019expressi\u00f3 de gens) i unes prote\u00efnes anomenades histones.<\/p>\n
\u201cHem observat\u201c, ha explicat l\u2019investigador Manel Esteller, \u201cque f\u00e0rmacs epigen\u00e8tics, capa\u00e7os de desmetilar l\u2019ADN, aprovats per a pacients d\u2019un subtipus de leuc\u00e8mia, s\u00f3n tamb\u00e9 capa\u00e7os d\u2019eliminar aquestes \u2018pilotes\u2019 dels gens antitumorals de manera que aquests tornen a expressar-se i recuperen la seva funci\u00f3\u201d.<\/p>\n
Aquest estudi, segons ha dit Esteller, tamb\u00e9 ha servit per descobrir nous gens inhibidors del c\u00e0ncer.<\/p>\n
El descobriment augmenta el coneixement molecular de les causes del c\u00e0ncer i, pel que fa l\u2019aplicaci\u00f3 cl\u00ednica de la troballa, Esteller ha explicat que \u201cactualment existeix un ampli ventall de f\u00e0rmacs en desenvolupament precl\u00ednic capa\u00e7os d\u2019expulsar els nucleosomes dels llocs aberrants del genoma\u201d.<\/p>\n
<\/p>\n
Refer\u00e8ncia de l\u2019article<\/strong> <\/em><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":" Les c\u00e8l\u00b7lules sanes viuen en un delicat equilibri entre els gens que promouen el creixement (oncogens) i els que el frenen (antioncogens o gens supressors tumorals). Aquest equilibri es trenca en les c\u00e8l\u00b7lules tumorals. Les causes en s\u00f3n moltes, com per exemple, l\u2019exist\u00e8ncia de mutacions, per\u00f2 destaca l\u2019adquisici\u00f3 d\u2019un senyal qu\u00edmic, la metilaci\u00f3, que bloqueja […]<\/p>\n","protected":false},"author":6,"featured_media":19453,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8537","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-09-14 21:32:32","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8537"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8537"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8537\/revisions"}],"predecessor-version":[{"id":19871,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8537\/revisions\/19871"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/19453"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8537"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8537"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n<\/strong> Portela A, Liz J, Nogales V, Seti\u00e9n F, Villanueva A, and Esteller M. DNA methylation determines nucleosome occupancy in the 5′-CpG islands of tumor suppressor genes<\/strong>. Oncogene doi: 10.1038\/onc, May 2013. <\/p>\n