{"id":8535,"date":"2013-06-13T00:00:00","date_gmt":"2013-06-12T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2013\/06\/13\/cel%e2%80%a2lules-mare-modificades-geneticament-son-efectives-contra-malalties-respiratories-agudes\/"},"modified":"2021-11-18T16:02:58","modified_gmt":"2021-11-18T15:02:58","slug":"cellules-mare-modificades-geneticament-son-efectives-contra-malalties-respiratories-agudes","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2013\/06\/cellules-mare-modificades-geneticament-son-efectives-contra-malalties-respiratories-agudes\/","title":{"rendered":"C\u00e8l\u2022lules mare modificades gen\u00e8ticament s\u00f3n efectives contra malalties respirat\u00f2ries agudes"},"content":{"rendered":"<p>Investigadors de l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i del <a href=\"http:\/\/www.vhir.org\/index.asp?Idioma=ca\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"enllac\">Vall d\u2019Hebron Institut de Recerca (VHIR)<\/span><\/a> han demostrat que l\u2019administraci\u00f3 de c\u00e8l\u00b7lules mare mesenquimals modificades gen\u00e8ticament regenera el teixit pulmonar i atura el proc\u00e9s inflamatori en ratolins amb lesi\u00f3 pulmonar aguda.<\/p>\n<p>Els resultats de l\u2019estudi s\u2019han publicat a la revista American Journal of Respiratory Cell and Molecular Biology.<\/p>\n<p><strong>Lesi\u00f3 pulmonar aguda <\/strong><\/p>\n<p>La lesi\u00f3 pulmonar aguda i la seva manifestaci\u00f3 m\u00e9s severa, la s\u00edndrome de destret respiratori agut, es caracteritzen per ser processos inflamatoris molt greus que danyen els pulmons amb una mortalitat d\u2019entre el 40% i el 50%. Actualment no existeix cap tractament efica\u00e7 m\u00e9s enll\u00e0 de les cures pal\u00b7liatives i l\u2019ajuda mec\u00e0nica a la respiraci\u00f3.<\/p>\n<p>\u201cDes de fa uns anys es treballa en la administraci\u00f3 de c\u00e8l\u00b7lules mare mesenquimals humanes procedents de teixit adip\u00f3s obtingut de liposuccions en diferents patologies\u201d, ha explicat l\u2019investigador del grup de Gen\u00e8tica Molecular Humana de l\u2019IDIBELL, Josep Maria Aran. \u201cNosaltres hem comprovat que aquestes c\u00e8l\u00b7lules mare s\u00f3n capaces d\u2019arribar f\u00e0cilment als pulmons i all\u00e0 secreten subst\u00e0ncies antiinflamat\u00f2ries i factors de creixement\u201d.<\/p>\n<p><strong>Senyal d\u2019alarma<\/strong><\/p>\n<p>Els estudis fets fins ara amb aquestes c\u00e8l\u00b7lules han demostrat un efecte positiu. Els investigadors de l\u2019IDIBELL i del VHIR han introdu\u00eft una modificaci\u00f3 gen\u00e8tica en aquestes c\u00e8l\u00b7lules que millora el tractament.<\/p>\n<p>La citoquina IL33 \u00e9s una prote\u00efna que actua com a senyal d\u2019alarma en aquests pacients. Quan s\u2019inicia el dany als pulmons, les c\u00e8l\u00b7lules secreten aquesta subst\u00e0ncia que \u00e9s altament proinflamat\u00f2ria i\u00a0provoca una resposta molt forta del sistema immunitari.<\/p>\n<p>\u201cVam pensar\u201d, explica Aran, \u201cque si modific\u00e0vem gen\u00e8ticament les c\u00e8l\u00b7lules mare mesenquimals perqu\u00e8 secretin una mol\u00e8cula antagonista de IL-33 podr\u00edem aturar el proc\u00e9s inflamatori i vam veure que, en ratolins, l\u2019efecte era m\u00e9s positiu que amb les c\u00e8l\u00b7lules sense modificar: hi ha regeneraci\u00f3 del teixit pulmonar i pr\u00e0cticament anul\u00b7la el proc\u00e9s inflamatori als pulmons\u201d.<\/p>\n<p>L\u2019IDIBELL ha signat un acord de llic\u00e8ncia amb l&#8217;empresa basca Histocell sobre aquesta modificaci\u00f3 gen\u00e8tica i actualment ja estan treballant perqu\u00e8 aquest \u201cmedicament intel\u00b7ligent\u201d pugui arribar a la fase cl\u00ednica i provar-lo amb pacients. <strong><br \/>\n<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigadors de l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i del Vall d\u2019Hebron Institut de Recerca (VHIR) han demostrat que l\u2019administraci\u00f3 de c\u00e8l\u00b7lules mare mesenquimals modificades gen\u00e8ticament regenera el teixit pulmonar i atura el proc\u00e9s inflamatori en ratolins amb lesi\u00f3 pulmonar aguda. Els resultats de l\u2019estudi s\u2019han publicat a la revista American Journal of Respiratory Cell [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":19847,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,334,464,378],"tags":[],"class_list":["post-8535","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar","category-medicina-translacional","category-p-de-gens-malaltia-i-terapia","category-processos-immune-inflamatoris-i-terapia-genica"],"publishpress_future_action":{"enabled":false,"date":"2025-03-02 15:22:54","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8535"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8535\/revisions"}],"predecessor-version":[{"id":19846,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8535\/revisions\/19846"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/19847"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}