Un antibi\u00f2tic que s\u2019utilitza actualment en veterin\u00e0ria anomenat thiostrepton inhibeix dos factors de transcripci\u00f3 relacionats amb l\u2019aparici\u00f3 del Sarcoma d\u2019Ewing, un c\u00e0ncer que afecta nens i joves. Es tracta d\u2019una prova de concepte realitzada en l\u00ednies cel\u00b7lulars i en ratolins. Tot i que no est\u00e0 previst que aquesta mateixa mol\u00e8cula es pugui utilitzar directament en humans, la troballa obre les portes a buscar nous f\u00e0rmacs que tinguin el mateix efecte.<\/p>\n
Els resultats de l\u2019estudi en qu\u00e8 ha col\u00b7laborat el cap del grup de recerca en sarcomes de l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) \u00d2scar Mart\u00ednez-Tirado, juntament amb investigadors de la Universitat de Georgetown, Washington, i de l\u2019Hospital Sant Joan de D\u00e9u de Barcelona, s\u2019han publicat en la revista International Journal of Oncology.<\/p>\n
El sarcoma d\u2019Ewing \u00e9s el segon c\u00e0ncer d\u2019os m\u00e9s com\u00fa i afecta nens i joves. Actualment, si es diagnostica a temps i no presenta met\u00e0stasi, es pot curar en el 80% dels casos per\u00f2 entre el 25% i el 30% dels casos es diagnostiquen quan ja existeix met\u00e0stasi i la superviv\u00e8ncia baixa fins al 30%.<\/p>\n
Factor de transcripci\u00f3 EWS\/FLI1<\/strong> <\/p>\n <\/strong> El sarcoma d\u2019Ewing es caracteritza per una translocaci\u00f3 cromos\u00f2mica que provoca l\u2019expressi\u00f3 de l\u2019oncogen EWS\/FLI1, responsable de la malaltia. \u201cTots els esfor\u00e7os per buscar noves ter\u00e0pies se centren en aturar aquest gen\u201d, ha explicat Mart\u00ednez-Tirado, \u201cper\u00f2 es tracta d\u2019un factor de transcripci\u00f3 i \u00e9s m\u00e9s complicat. Nosaltres estem treballant en ter\u00e0pia g\u00e8nica per\u00f2 encara estem lluny que es pugui aplicar en humans\u201d.<\/p>\n EWS\/FLI1 promou l\u2019expressi\u00f3 de tot un ventall de gens que en condicions normals no s\u2019expressarien i que promouen l\u2019inici del tumor i tamb\u00e9 la seva met\u00e0stasi. Entre els gens que activa aquest oncogen est\u00e0 un altre factor de transcripci\u00f3 anomenat FoxM1 que s\u2019ha descrit anteriorment com a oncog\u00e8nic en altres tipus de tumors.<\/p>\n Efecte dual<\/strong> <\/p>\n <\/strong> Els investigadors van provar el thiostrepton en l\u00ednies cel\u00b7lulars i ratolins amb sarcoma d\u2019Ewing i van observar que l\u2019antibi\u00f2tic no nom\u00e9s inhibia FoxM1, com ja s\u2019havia descrit en un altre estudi, sin\u00f3 que tamb\u00e9 inhibia l\u2019oncogen EWS\/FL1.<\/p>\n \u201cEn l\u00ednies cel\u00b7lulars vam observar que aquesta mol\u00e8cula parava el cicle cel\u00b7lular de les c\u00e8l\u00b7lules tumorals i a m\u00e9s indu\u00efa apoptosi, \u00e9s a dir mort cel\u00b7lular\u201d, ha explicat Mart\u00ednez-Tirado. \u201cEn ratolins, l\u2019antibi\u00f2tic retardava casi cinc vegades el creixement de tumor\u201d.<\/p>\n L\u2019efecte dual d\u2019aquest antibi\u00f2tic sobre aquests dos factors de transcripci\u00f3 significa una nova opci\u00f3 terap\u00e8utica contra el sarcoma d\u2019Ewing. L\u2019investigador ha advertit que aquesta mol\u00e8cula probablement no es podr\u00e0 utilitzar en humans per\u00f2 que \u201caquests resultats obren la porta a que altres grups treballin en el desenvolupament de mol\u00e8cules an\u00e0logues amb millors caracter\u00edstiques farmacocin\u00e8tiques\u201d.<\/p>\n <\/p>\n Refer\u00e8ncia de l\u2019article<\/strong> Un antibi\u00f2tic que s\u2019utilitza actualment en veterin\u00e0ria anomenat thiostrepton inhibeix dos factors de transcripci\u00f3 relacionats amb l\u2019aparici\u00f3 del Sarcoma d\u2019Ewing, un c\u00e0ncer que afecta nens i joves. Es tracta d\u2019una prova de concepte realitzada en l\u00ednies cel\u00b7lulars i en ratolins. Tot i que no est\u00e0 previst que aquesta mateixa mol\u00e8cula es pugui utilitzar directament en […]<\/p>\n","protected":false},"author":6,"featured_media":19809,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,332,447,398],"tags":[],"class_list":["post-8521","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar","category-cancer","category-p-de-mecanismes-molelculars-i-terapia-experimental-en-oncologia-oncobell","category-sarcoma"],"publishpress_future_action":{"enabled":false,"date":"2025-03-02 13:17:08","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8521","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8521"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8521\/revisions"}],"predecessor-version":[{"id":19810,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8521\/revisions\/19810"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/19809"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8521"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8521"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8521"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n<\/strong> Sengupta A., Rahman M., Mateo_Lozano S., Mart\u00ednez-Tirado O. and Notario V. The Dual inhibitory effect of Thiostrepton on FoxM1 provides a novel therapeutic option for Ewing\u2019s Sarcoma. International Journal of Oncolgy. Juliol 2013<\/p>\n","protected":false},"excerpt":{"rendered":"