Un dels objectius de la recerca en gen\u00e8tica i biologia molecular del c\u00e0ncer \u00e9s aconseguir un tractament “a la carta”, \u00e9s a dir, que estudiant les alteracions presents en un tumor es pugui decidir quin \u00e9s el f\u00e0rmac m\u00e9s efectiu amb la m\u00ednima toxicitat.<\/p>\n
C\u00f2pies extres<\/strong><\/p>\n “Hem trobat que entre un 5-10% dels tumors de pulm\u00f3, en comptes de tenir la dosi normal de l’oncogen (dues c\u00f2pies, una en el cromosoma matern i una altra al patern) posseeixen una sobredosi del mateix, al voltant de 10 c\u00f2pies extres del gen\u201d ha explicat Manel Esteller, director de l’estudi. L’oncog\u00e8n identificat origina la prote\u00efna SETDB1, un histona metiltransferasa. Es tracta d’un enzim que es pot inhibir amb compostos en qu\u00e8 la ind\u00fastria farmacol\u00f2gica t\u00e9 experi\u00e8ncia.<\/p>\n “El nostre estudi” ha explicat Esteller “assenyala un punt feble de la muralla defensiva de la c\u00e8l\u00b7lula tumoral que ha estat possible detectar gr\u00e0cies al projecte europeu CURELUNG i ara volem que alguna companyia segueixi aquesta l\u00ednia d’investigaci\u00f3 perqu\u00e8 en un futur es disposi d’un f\u00e0rmac aplicable en els pacients “.<\/p>\n <\/p>\n Refer\u00e8ncia de l\u2019article<\/strong> Un dels objectius de la recerca en gen\u00e8tica i biologia molecular del c\u00e0ncer \u00e9s aconseguir un tractament “a la carta”, \u00e9s a dir, que estudiant les alteracions presents en un tumor es pugui decidir quin \u00e9s el f\u00e0rmac m\u00e9s efectiu amb la m\u00ednima toxicitat. C\u00f2pies extres “Hem trobat que entre un 5-10% dels tumors de […]<\/p>\n","protected":false},"author":6,"featured_media":19806,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,332],"tags":[],"class_list":["post-8520","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar","category-cancer"],"publishpress_future_action":{"enabled":false,"date":"2024-11-24 17:21:49","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8520"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8520\/revisions"}],"predecessor-version":[{"id":19807,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8520\/revisions\/19807"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/19806"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8520"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nRodriguez-Paredes M, Martinez de Paz A, Sim\u00f3-Riudalbas L, Sayols S, Moutinho C, Moran S, Villanueva A, V\u00e1zquez-Cedeira M, Lazo PA, Carneiro F, Moura CS, Vieira J, Teixeira MR, Esteller M. Gene Amplification of the Histone Methyltransferase SETDB1 Contributes to Human Lung Tumorigenesis. Oncogene<\/em>, doi: 10.1038\/onc.2013.239., 2013.<\/p>\n","protected":false},"excerpt":{"rendered":"