La l\u00edder del grup de recerca en la transformaci\u00f3 i la met\u00e0stasi de l’Institut de Recerca Biom\u00e8dica de Bellvitge (IDIBELL), Eva Gonz\u00e1lez-Su\u00e1rez, ha estat guardonada amb un projecte de recerca de Susan G. Komen \u00ae, l’organitzaci\u00f3 de c\u00e0ncer de mama m\u00e9s important del m\u00f3n. El projecte est\u00e0 finan\u00e7at amb 450.000 d\u00f2lars per als propers tres anys.<\/p>\n
Komen va ser fundada el 1982 amb l’objectiu de salvar vides i guarir el c\u00e0ncer de mama per sempre. En els darrers 30 anys, Komen ha invertit m\u00e9s de 755 milions de d\u00f2lars en centenars de projectes de recerca del c\u00e0ncer de mama a tot el m\u00f3n, especialment als EUA.<\/p>\n
El projecte que ha rebut Eva Gonz\u00e1lez-Su\u00e1rez es troba a la categoria de \u00abcareer catalyst\u00bb per a joves investigadors i entre els requisits d’acceptaci\u00f3 hi havia presentar un projecte que potencialment podria significar beneficis per als pacients en un termini m\u00e0xim de deu anys. Segons ha explicat la investigadora, el projecte que ha obtingut el premi estudia la possibilitat de fer servir la via de senyalitzaci\u00f3 RANK com a nova diana terap\u00e8utica en c\u00e0ncer de mama; “\u00e9s prou esperan\u00e7ador per pensar que en deu anys pugui estar a l’abast de la cl\u00ednica”.<\/p>\n
El grup d’Eva Gonz\u00e1lez-Su\u00e1rez ha demostrat en ratolins i l\u00ednies cel\u00b7lulars humanes que una sobreexpressi\u00f3 de la via de senyalitzaci\u00f3 RANK promou la iniciaci\u00f3, la progressi\u00f3 i la met\u00e0stasi del c\u00e0ncer de mama. Tamb\u00e9 han vist que un inhibidor d’aquesta via, un f\u00e0rmac que ja es fa servir per al tractament de met\u00e0stasi \u00f2ssies i osteoporosi, prev\u00e9 la formaci\u00f3 de tumors de mama intervinguts per progesterona i t\u00e9 un efecte preventiu en la iniciaci\u00f3 tumoral i en la met\u00e0stasi pulmonar. “El projecte de la Fundaci\u00f3 Susan Komen ens permetr\u00e0 estudiar la via RANK com a nova diana terap\u00e8utica des de dues aproximacions diferents” ha explicat Gonz\u00e1lez-Su\u00e1rez “d’una banda analitzarem els patrons d’expressi\u00f3 la via RANK de m\u00e9s de 300 mostres de pacients de c\u00e0ncer de mama. De manera que podrem correlacionar aquests patrons amb la incid\u00e8ncia de met\u00e0stasi i amb la resposta a tractaments actualment aprovats\u201d.<\/p>\n
La segona aproximaci\u00f3 del projecte del laboratori que lidera la investigadora ser\u00e0 modular l’expressi\u00f3 de la via RANK en models de ratol\u00ed als quals s’ha implantat un tumor de mama hum\u00e0. \u201c\u00c9s un model precl\u00ednic, per\u00f2 ja estem molt a prop del pacient perqu\u00e8 podem avaluar in vivo l’evoluci\u00f3 del tumor hum\u00e0\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"
La l\u00edder del grup de recerca en la transformaci\u00f3 i la met\u00e0stasi de l’Institut de Recerca Biom\u00e8dica de Bellvitge (IDIBELL), Eva Gonz\u00e1lez-Su\u00e1rez, ha estat guardonada amb un projecte de recerca de Susan G. Komen \u00ae, l’organitzaci\u00f3 de c\u00e0ncer de mama m\u00e9s important del m\u00f3n. El projecte est\u00e0 finan\u00e7at amb 450.000 d\u00f2lars per als propers tres […]<\/p>\n","protected":false},"author":6,"featured_media":19793,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,332,447,371],"tags":[],"class_list":["post-8515","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar","category-cancer","category-p-de-mecanismes-molelculars-i-terapia-experimental-en-oncologia-oncobell","category-transformacio-i-metastasi"],"publishpress_future_action":{"enabled":false,"date":"2024-11-30 04:21:19","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8515","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8515"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8515\/revisions"}],"predecessor-version":[{"id":19794,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8515\/revisions\/19794"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/19793"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8515"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8515"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8515"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}