Investigadors del grup de recerca en Transformaci\u00f3 i Met\u00e0stasi de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), liderat per Eva Gonz\u00e1lez-Su\u00e1rez, han demostrat que la sobreexpressi\u00f3 de la via de senyalitzaci\u00f3 RANK interfereix en la diferenciaci\u00f3 de les c\u00e8l\u00b7lules que formen les gl\u00e0ndules mam\u00e0ries. Aix\u00f2 produeix una acumulaci\u00f3 de c\u00e8l\u00b7lules indiferenciades que finalment condueix al desenvolupament del tumor.<\/p>\n
En estudis anteriors, el laboratori d’Eva Gonzalez-Su\u00e1rez ja havia demostrat que la sobreactivaci\u00f3 de la via de senyalitzaci\u00f3 RANK afavoreix l’inici, la progressi\u00f3 i la met\u00e0stasi dels tumors a les c\u00e8l\u00b7lules epitelials de la mama.<\/p>\n
En aquest article, publicat a la revista Stem Cells, els investigadors han estudiat \u00e0mpliament el paper de RANK en la diferenciaci\u00f3 de c\u00e8l\u00b7lules mamaries d’un model de ratol\u00ed transg\u00e8nic que presenta una sobreactivaci\u00f3 d’aquesta via.<\/p>\n
Llinatges de c\u00e8l\u00b7lules mam\u00e0ries<\/strong><\/p>\n En un ratol\u00ed no transg\u00e8nic, amb nivells normals de RANK, les c\u00e8l\u00b7lules dels conductes (tubs per on circula la llet per les gl\u00e0ndules mam\u00e0ries) es diferencien en dos llinatges: les c\u00e8l\u00b7lules luminals que s’orienten al lumen del conducte i les c\u00e8l\u00b7lules basals de folre.<\/p>\n “Les dues poblacions cel\u00b7lulars estan ben separades i ordenades”, explica Eva Gonz\u00e1lez-Su\u00e1rez, “per\u00f2 en animals modificats gen\u00e8ticament amb alts nivells d’expressi\u00f3 de RANK es van observar diverses anomalies que afecten la morfologia: els conductes estan desorganitzats, no formen capes cont\u00ednues de c\u00e8l\u00b7lules i aquestes no estan orientats com haurien de ser”.<\/p>\n Mitjan\u00e7ant diverses t\u00e8cniques, els investigadors han demostrat que els ratolins amb sobreactivaci\u00f3 de la via RANK acumulen c\u00e8l\u00b7lules mare de mama que no tenen c\u00e8l\u00b7lules diferenciades amb caracter\u00edstiques basals i luminals, \u00e9s a dir, c\u00e8l\u00b7lules progenitores interm\u00e8dies que no han realitzat el proc\u00e9s de diferenciaci\u00f3. “Aquesta acumulaci\u00f3 -va dir Gonz\u00e1lez-Su\u00e1rez- condueix al desenvolupament de tumors heterogenis”.<\/p>\n L’estudi tamb\u00e9 mostra que en els ratolins no modificats a mesura que envelleixen i despr\u00e9s de molts embarassos, de manera natural els nivells de RANK augmenten, cosa que podria explicar que amb l’edat augmenta el risc de c\u00e0ncer de mama.<\/p>\n <\/p>\n Refer\u00e8ncia de l\u2019article<\/strong> Investigadors del grup de recerca en Transformaci\u00f3 i Met\u00e0stasi de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), liderat per Eva Gonz\u00e1lez-Su\u00e1rez, han demostrat que la sobreexpressi\u00f3 de la via de senyalitzaci\u00f3 RANK interfereix en la diferenciaci\u00f3 de les c\u00e8l\u00b7lules que formen les gl\u00e0ndules mam\u00e0ries. Aix\u00f2 produeix una acumulaci\u00f3 de c\u00e8l\u00b7lules indiferenciades que finalment condueix al desenvolupament […]<\/p>\n","protected":false},"author":6,"featured_media":19781,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,332,390,447,452,371],"tags":[],"class_list":["post-8512","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar","category-cancer","category-cancer-de-mama","category-p-de-mecanismes-molelculars-i-terapia-experimental-en-oncologia-oncobell","category-procure","category-transformacio-i-metastasi"],"publishpress_future_action":{"enabled":false,"date":"2024-11-30 00:25:51","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8512","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8512"}],"version-history":[{"count":4,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8512\/revisions"}],"predecessor-version":[{"id":19865,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8512\/revisions\/19865"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/19781"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8512"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8512"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8512"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n<\/strong> Pellegrini P., Cordero A., Gallego M., William D.C., Mu\u00f1oz P., Pujana M. And Gonz\u00e1lez-Su\u00e1rez E. Constitutive activation of RANK disrupts mamary cell fate leading to tumorigenesis. Stem Cells. 2013.<\/p>\n","protected":false},"excerpt":{"rendered":"