{"id":8504,"date":"2013-09-27T00:00:00","date_gmt":"2013-09-26T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2013\/09\/27\/un-estudi-de-lidibell-questiona-el-dogma-que-afirma-que-quan-els-falten-nutrients-les-cel%e2%80%a2lules-es-mengen-per-dins\/"},"modified":"2021-12-20T11:53:52","modified_gmt":"2021-12-20T10:53:52","slug":"un-estudi-de-lidibell-questiona-el-dogma-que-afirma-que-quan-els-falten-nutrients-les-cellules-es-mengen-per-dins","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2013\/09\/un-estudi-de-lidibell-questiona-el-dogma-que-afirma-que-quan-els-falten-nutrients-les-cellules-es-mengen-per-dins\/","title":{"rendered":"Un estudi de l&#8217;IDIBELL q\u00fcestiona el dogma que afirma que quan els falten nutrients les c\u00e8l\u2022lules es mengen per dins"},"content":{"rendered":"<p><strong>El treball conclou<\/strong><strong> que la manca de glucosa, un nutrient essencial per a generar energia, no indueix autof\u00e0gia en les c\u00e8l\u00b7lules<\/strong><\/p>\n<p>L&#8217;autof\u00e0gia \u00e9s un mecanisme de protecci\u00f3 que utilitzen les c\u00e8l\u00b7lules en situacions d&#8217;estr\u00e8s. Degraden seus org\u00e0nuls i els reciclen per generar energia i sobreviure. Fins ara es creia que en totes les situacions de manca de nutrients, les c\u00e8l\u00b7lules iniciaven l&#8217;autof\u00e0gia. Un estudi de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) liderat per Cristina Mu\u00f1oz-Pinedo q\u00fcestiona aquest dogma.<\/p>\n<p>&#8220;Hem comprovat en diverses l\u00ednies cel\u00b7lulars que la manca de glucosa no indueix l&#8217;autof\u00e0gia&#8221; ha explicat la investigadora. Els resultats de l&#8217;estudi s&#8217;han publicat a la revista Journal of Biological Chemistry. &#8220;Els inhibidors de l&#8217;autof\u00e0gia s&#8217;estan proposant com a nous f\u00e0rmacs antitumorals, ja que es creu que l&#8217;autof\u00e0gia \u00e9s un mecanisme de protecci\u00f3 de les c\u00e8l\u00b7lules tumorals per poder seguir creixent en ambients pobres en nutrients&#8221; continua Mu\u00f1oz-Pinedo &#8220;i el fet que la falta de glucosa, un nutrient essencial, no condueixi a l&#8217;autof\u00e0gia fa que ens haguem de replantejar el paper d&#8217;aquest mecanisme com a resposta a la manca de nutrients &#8220;.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Refer\u00e8ncia de l\u2019article<\/strong> <strong><br \/>\n<\/strong>Ram\u00edrez-Peinado S., Le\u00f3n-Annicchiarico C.L., Galindo-Moreno J., Caro-Maldonado A., Prehm J.H., Ryan K.M. and Mu\u00f1oz-Pinedo C. Glucose starved cells din not engage in pro-survival autophagy. The Journal of Biological Chemistry. 2013 sep 6.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>El treball conclou que la manca de glucosa, un nutrient essencial per a generar energia, no indueix autof\u00e0gia en les c\u00e8l\u00b7lules L&#8217;autof\u00e0gia \u00e9s un mecanisme de protecci\u00f3 que utilitzen les c\u00e8l\u00b7lules en situacions d&#8217;estr\u00e8s. Degraden seus org\u00e0nuls i els reciclen per generar energia i sobreviure. Fins ara es creia que en totes les situacions de [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":19755,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,448,332,447,333],"tags":[],"class_list":["post-8504","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar","category-apoptosi-i-cancer","category-cancer","category-p-de-mecanismes-molelculars-i-terapia-experimental-en-oncologia-oncobell","category-metabolisme-i-mort-cellular"],"publishpress_future_action":{"enabled":false,"date":"2025-03-02 12:33:00","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8504"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8504\/revisions"}],"predecessor-version":[{"id":19756,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8504\/revisions\/19756"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/19755"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8504"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8504"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}