El c\u00e0ncer de pulm\u00f3 \u00e9s actualment el m\u00e9s letal en el m\u00f3n . La principal causa d’aquests tumors \u00e9s el tabac i se solen diagnosticar en fases avan\u00e7ades quan ja hi ha poques opcions de tractament . Hi ha un subgrup de tumors de pulm\u00f3 que gr\u00e0cies als aven\u00e7os diagn\u00f2stics es poden detectar en fases m\u00e9s primerenques i en els quals la cirurgia pot ser m\u00e9s curativa . S\u00f3n els anomenats tumors de pulm\u00f3 petits . No obstant aix\u00f2 , una tercera part d’aquests tumors s\u00f3n altament agressius i amb una elevada predisposici\u00f3 a generar met\u00e0stasi .<\/p>\n
El 30 de setembre la revista oficial de la Societat Americana d’Oncologia M\u00e8dica , el Journal of Clinical Oncology publica un article liderat per Manel Esteller, director del Programa d’ Epigen\u00e8tica i Biologia del C\u00e0ncer de l’Institut d’Investigacions Biom\u00e8diques de Bellvitge (IDIBELL), Investigador ICREA i Professor de Gen\u00e8tica de la Universitat de Barcelona, \u200b\u200bque permet identificar aquests tumors de pulm\u00f3 min\u00fasculs per\u00f2 altament malignes .<\/p>\n
” L’estudi que hem coordinat \u00e9s un projecte internacional finan\u00e7at per la Uni\u00f3 Europea on hem analitzat c\u00e0ncer de pulm\u00f3 en estadi I, aquells tumors on la cirurgia podria ser curativa. Hem comprovat que un de cada tres tumors petits reapareixer\u00e0 i s’associar\u00e0 amb la mort d’aquest pacient. Per\u00f2 el m\u00e9s important \u00e9s que ja podem comen\u00e7ar a identificar que c\u00e0ncer es comportar\u00e0 d’aquesta forma tan agressiva ” ha explicat Manel Esteller, director del treball .<\/p>\n
“Analitzant l’ADN d’aquests tumors hem detectat que presenten alteracions en el seu programa gen\u00e8tic, les anomenades lesions epigen\u00e8tiques, associades a la seva major facilitat de cr\u00e9ixer i expandir-se a la resta del cos. Concretament presenten canvis en gens que els converteixen en tumors indiferenciats (gens homeobox) amb un aspecte m\u00e9s tou (gens mesenquimals)”.<\/p>\n
La troballa representa no nom\u00e9s el descobriment de marcadors de pron\u00f2stic de la malaltia que indiquen com de r\u00e0pid progressar\u00e0 , sin\u00f3 que tamb\u00e9 poden ser \u00fatils per al seu tractament. ” Si sabem d\u2019entrada que el tumor petit ser\u00e0 molt agressiu , millor que no ens conformem amb la simple extirpaci\u00f3 quir\u00fargica del mateix i comencem a estudiar si hem d’afegir quimioter\u00e0pia per tractar aquests tumors d’elevat risc ” conclou Manel Esteller .<\/p>\n
A Europa es diagnostiquen cada any m\u00e9s de 150.000 casos de c\u00e0ncer de pulm\u00f3 , un 90% d’ells a causa del tabac . Nom\u00e9s entre un 10 i un 15% sobreviuen cinc anys despr\u00e9s del diagn\u00f2stic .<\/p>\n
Refer\u00e8ncia de l\u2019article <\/strong> Pollan M, Pajares MJ, Torre W, Montuenga LM, Brambilla E, Field JK, Roz L, Iacono ML, Scagliotti GV, Rosell R, Beer DG, Esteller M. A Prognostic DNA Methylation Signature for Stage I Non-Small Cell Lung Cancer. Journal of Clinical Oncology, September 30, 2013.<\/p>\n","protected":false},"excerpt":{"rendered":" El c\u00e0ncer de pulm\u00f3 \u00e9s actualment el m\u00e9s letal en el m\u00f3n . La principal causa d’aquests tumors \u00e9s el tabac i se solen diagnosticar en fases avan\u00e7ades quan ja hi ha poques opcions de tractament . Hi ha un subgrup de tumors de pulm\u00f3 que gr\u00e0cies als aven\u00e7os diagn\u00f2stics es poden detectar en fases […]<\/p>\n","protected":false},"author":6,"featured_media":19742,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,332],"tags":[],"class_list":["post-8502","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar","category-cancer"],"publishpress_future_action":{"enabled":false,"date":"2025-01-29 08:28:09","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8502","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8502"}],"version-history":[{"count":4,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8502\/revisions"}],"predecessor-version":[{"id":19757,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8502\/revisions\/19757"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/19742"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8502"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8502"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8502"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nSandoval J, Mendez-Gonzalez J, Nadal E, Chen G, Carmona FJ, Sayols S, Moran S, Heyn H, Vizoso M, Gomez A, Sanchez-Cespedes M, Assenov Y, M\u00fcller F, Bock C, Taron M, Mora J, Muscarella LA, Liloglou T, Davies M,<\/p>\n