Un estudi de l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) dirigit per la cap del grup de recerca en vies de senyalitzaci\u00f3 en angiog\u00e8nesi, Mariona Graupera, conclou que la inhibici\u00f3 de la prote\u00efna p110alfa en ratolins provoca una reducci\u00f3 dels creixement tumoral associat a un defecte en la formaci\u00f3 de vasos sanguinis. Els resultats de l\u2019estudi s\u2019han publicat a la revista Journal of Experimental Medicine.<\/p>\n
La p110alfa \u00e9s una isoforma (una variant) de la prote\u00efna PI3Kinasa que est\u00e0 alterada d\u2019una forma o altra en m\u00e9s del 30% dels tumors. En un estudi anterior, el grup de Graupera ja havia demostrat que aquesta isoforma t\u00e9 un paper clau en el proc\u00e9s fisiol\u00f2gic de formaci\u00f3 vasos sanguinis, anomenada angiog\u00e8nesi. \u201cEl que hem volgut comprovar en aquest treball\u201d diu la investigadora \u201c\u00e9s si en context de c\u00e0ncer tamb\u00e9 juga aquest rol\u201d.<\/p>\n
Angiog\u00e8nesi<\/strong> <\/p>\n <\/strong> L\u2019angiog\u00e8nesi \u00e9s un proc\u00e9s clau en el creixement, proliferaci\u00f3 i migraci\u00f3 dels tumors s\u00f2lids. Les c\u00e8l\u00b7lules tumorals necessiten nous vasos sanguinis que els aportin l\u2019oxigen i els nutrients extra que necessiten per desenvolupar-se a un ritme tan r\u00e0pid.<\/p>\n Els investigadors van inhibir la p110alfa mitjan\u00e7ant dues estrat\u00e8gies: amb f\u00e0rmacs i amb ratolins modificats gen\u00e8ticament que no expressen la prote\u00efna. \u201cEn tots dos casos\u201d ha explicat Mariona Graupera \u201cla seva inhibici\u00f3 provoca un alentiment del creixement tumoral, associat a un defecte en la formaci\u00f3 dels vasos\u201d.<\/p>\n \u201cEs formen m\u00e9s vasos per\u00f2 s\u00f3n m\u00e9s petits del normal i no funcionen b\u00e9. De manera que a les c\u00e8l\u00b7lules tumorals no els arriba tot l\u2019oxigen i els nutrients que necessiten\u201d.<\/p>\n Alternativa a les ter\u00e0pies convencionals<\/strong> <\/p>\n <\/strong> Tot i que de forma molt inicial, segons Graupera \u201caquest estudi obre les portes a noves ter\u00e0pies antiangiog\u00e8niques alternatives a les convencionals que inhibeixen VEGF i que a la llarga poden desenvolupar resist\u00e8ncia i malignitat.\u201d<\/p>\n Refer\u00e8ncia de l\u2019article<\/strong> Un estudi de l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) dirigit per la cap del grup de recerca en vies de senyalitzaci\u00f3 en angiog\u00e8nesi, Mariona Graupera, conclou que la inhibici\u00f3 de la prote\u00efna p110alfa en ratolins provoca una reducci\u00f3 dels creixement tumoral associat a un defecte en la formaci\u00f3 de vasos sanguinis. Els resultats de l\u2019estudi […]<\/p>\n","protected":false},"author":6,"featured_media":19731,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,397,332,452,425],"tags":[],"class_list":["post-8499","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar","category-angiogenesi-tumoral","category-cancer","category-procure","category-senyalitzacio-molecular"],"publishpress_future_action":{"enabled":false,"date":"2024-12-29 21:12:19","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8499","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8499"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8499\/revisions"}],"predecessor-version":[{"id":19732,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8499\/revisions\/19732"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/19731"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8499"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8499"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8499"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n<\/strong>Soler A., Serra H., Pearce W., Angulo A., Guillermet-Guibert J., Friedman L.S., Vi\u00f1als F., Gerhardt H., Casanovas O., Graupera M. and Bart Vanhaesebroeck. Inhibition of the 110alpha isofrom of PI 3-Kinase stimulates nonfunctional tumor angiogenesis. The Journal of Experimental Medicien. 2013. september<\/p>\n","protected":false},"excerpt":{"rendered":"