Un estudi internacional entre el grup d’Impressi\u00f3 Gen\u00f2mica del Programa d\u2019Epigen\u00e8tica i Biologia del C\u00e0ncer de l’IDIBELL i la Universitat Christian-Albrechts de Kiel, Alemanya, descriu una firma de metilaci\u00f3 que \u00e9s un marcador prometedor per a la classificaci\u00f3 de les leuc\u00e8mies mieloides derivades. <\/p>\n
El gen del tumor de Wilms 1 ( WT1 ) est\u00e0 sobreexpressat en nombrosos tipus de c\u00e0ncer respecte a les c\u00e8l\u00b7lules normals, i t\u00e9 una funci\u00f3 oncog\u00e8nica o de supressor de tumors depenent del context cel\u00b7lular. <\/p>\n
L’estudi publicat a la Revista Hematology and Oncology (Guiliaumet-Adkins et al., 2014) va revelar que tot i l’alta expressi\u00f3 de WT1 en l\u00ednies cel\u00b7lulars derivades de leuc\u00e8mia mieloide aguda (LMA), existeix un interruptor epigen\u00e8tic que fa passar de la forma permissiva a la repressiva de la cromatina. L’an\u00e0lisi de metilaci\u00f3 en 356 mostres de leuc\u00e8mia i limfoma primari va revelar que la signatura epigen\u00e8tica identificada en l\u00ednies cel\u00b7lulars \u00e9s espec\u00edfica de llinatges malignes, independentment de l’estat mutacional subjacent o translocaci\u00f3. <\/p>\n
David Monk va explicar que “hem demostrat que la signatura epigen\u00e8tica AWT1 \u00e9s un excel\u00b7lent marcador per discriminar la LMA de sang perif\u00e8rica no malalta i que aquesta firma pot rastrejar amb precisi\u00f3 la progressi\u00f3 de la malaltia, diferenciant pacients que han recaigut dels que van aconseguir la remissi\u00f3 completa despr\u00e9s del trasplantament al\u00b7log\u00e8nic de c\u00e8l\u00b7lules mare hematopo\u00e8tiques ( SCT )”. <\/p>\n
La hipermetilaci\u00f3 del promotor AWT1 alternativa en neopl\u00e0sies hematol\u00f2giques \u00e9s un marcador altament espec\u00edfic per a les leuc\u00e8mies mieloides agudes malgrat els nivells elevats d’expressi\u00f3 . Guillaumet – Adkins A, J Richter , Odero MD , Sandoval J , Agirre X , Catala A, Esteller M , Pr\u00f3sper F , Calassan\u00e7 MJ , Bu\u00f1o I, Kwon M , Cort F , R Siebert , Monk D. J Hematol Oncol . 2014 gener 9 , 7 (1 ): 4.<\/p>\n","protected":false},"excerpt":{"rendered":"
Un estudi internacional entre el grup d’Impressi\u00f3 Gen\u00f2mica del Programa d\u2019Epigen\u00e8tica i Biologia del C\u00e0ncer de l’IDIBELL i la Universitat Christian-Albrechts de Kiel, Alemanya, descriu una firma de metilaci\u00f3 que \u00e9s un marcador prometedor per a la classificaci\u00f3 de les leuc\u00e8mies mieloides derivades. El gen del tumor de Wilms 1 ( WT1 ) est\u00e0 sobreexpressat […]<\/p>\n","protected":false},"author":6,"featured_media":8438,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8437","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2025-01-25 09:06:14","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8437"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8437\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/8438"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8437"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8437"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}