L\u2019estrogen \u00e9s una hormona femenina essencial que compleix moltes funcions b\u00e0siques en l\u2019organisme. No obstant aix\u00f2, en certes ocasions tamb\u00e9 pot originar o afavorir el creixement d’alguns tipus de c\u00e0ncer, com ara el de mama, ja qu\u00e8 estimula el creixement i la divisi\u00f3 de les c\u00e8l\u00b7lules tumorals. <\/p>\n
Els tumors que responen a l\u2019estrogen es coneixen com a \u201cpositius pel receptor d\u2019estrogen\u201d i es combaten, entre d\u2019altres, amb l\u2019administraci\u00f3 de f\u00e0rmacs \u201canti-estrog\u00e8nics\u201d. Aquest tipus de tumors en donen en aproximadament dos ter\u00e7os del total de pacients. En molts d\u2019aquests casos, per\u00f2, el tumor, que inicialment respon al tractament, acaba fent-se resistent, el que provoca la progressi\u00f3 del c\u00e0ncer.<\/p>\n
Un estudi internacional liderat per la Unitat de C\u00e0ncer de Mama i el Laboratori de Recerca Translacional de l\u2019ICO-IDIBELL que es publica a Breast Cancer Research<\/em> ha analitzat els mecanismes moleculars que faciliten la resist\u00e8ncia de les c\u00e8l\u00b7lules cancer\u00edgenes a les ter\u00e0pies anti-estrog\u00e8niques. <\/p>\n El treball, encap\u00e7alat per Miquel \u00c0ngel Pujana, ha identificat la activitat de la prote\u00efna VAV3 com clau en aquest proc\u00e9s. Segons l\u2019estudi, baixos nivells d\u2019expressi\u00f3 de VAV3 comporten una millor resposta a la ter\u00e0pia hormonal (e.g. basada en tamoxif\u00e8), mentre que una elevada expressi\u00f3 s\u2019associa a una pitjor resposta. A m\u00e9s han identificat variants gen\u00e8tiques en el gen que codifica per VAV3 que prediuen la resposta a la ter\u00e0pia. Segons aix\u00f2, disminuir el nivell d\u2019expressi\u00f3 o activitat de VAV3 seria una bona estrat\u00e8gia per evitar la resist\u00e8ncia als tractaments anti-estr\u00f2genics. En aquest sentit, el grup de recerca ha iniciat estudis experimentals en models pre-cl\u00ednics.<\/p>\n","protected":false},"excerpt":{"rendered":" L\u2019estrogen \u00e9s una hormona femenina essencial que compleix moltes funcions b\u00e0siques en l\u2019organisme. No obstant aix\u00f2, en certes ocasions tamb\u00e9 pot originar o afavorir el creixement d’alguns tipus de c\u00e0ncer, com ara el de mama, ja qu\u00e8 estimula el creixement i la divisi\u00f3 de les c\u00e8l\u00b7lules tumorals. Els tumors que responen a l\u2019estrogen es coneixen […]<\/p>\n","protected":false},"author":6,"featured_media":11006,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-26 06:02:41","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8357"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8357"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8357\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/11006"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}