La major part de les investigacions sobre els gens en c\u00e0ncer hum\u00e0, s’han centrat en les regions del genoma anomenades codificants (exons) que s\u00f3n les que es tradueixen en forma d’amino\u00e0cids i per tant de prote\u00efnes. Per\u00f2 just abans de cada gen, hi ha una regi\u00f3 reguladora o activadora que controla l’expressi\u00f3 i activitat del gen adjacent. Fins ara, es coneixia molt poc del paper que exercien aquests fragment de l’ADN en el desenvolupament de tumors. <\/p>\n
Un article publicat avui a Nature<\/em> amb la col\u00b7laboraci\u00f3 del grup de Manel Esteller, director del Programa d’Epigen\u00e8tica i Biologia del C\u00e0ncer de l’Institut d’Investigacions Biom\u00e8diques de Bellvitge (IDIBELL), Investigador ICREA i professor de Gen\u00e8tica de la Universitat de Barcelona, demostra que aquestes regions es troben tamb\u00e9 alterades en c\u00e0ncer. <\/p>\n “Els resultats de l’estudi de Nature<\/em> revelen que les regions reguladores que precedeixen al gen com a tal, s\u00f3n variables, poden mutar i ser modificades qu\u00edmicament, com per exemple amb la metilaci\u00f3 de l’ADN, en les c\u00e8l\u00b7lules de la transformaci\u00f3 tumoral” declara Manel Esteller, co-autor de l’estudi. <\/p>\n “Estudiant una extensa cohort de pacients de c\u00e0ncer de c\u00f2lon, un tipus de tumor molt freq\u00fcent en la nostra societat, ens vam adonar que aquestes zones de control dels gens estaven tan lesionades com els mateixos gens i causaven una funci\u00f3 alterada del gen diana. A m\u00e9s el treball mostra una nova llista de gens implicats en l’aparici\u00f3 del c\u00e0ncer, desconeguts fins ara, que s\u00f3n aberrants simplement per un mal control d’aquestes regions promotores “. <\/p>\n Aquests descobriments poden tenir una import\u00e0ncia profunda en la comprensi\u00f3 de la biologia del c\u00e0ncer ja qu\u00e8 subratllen la necessitat de no nom\u00e9s de centrar-se en la regi\u00f3 dels gens m\u00e9s cl\u00e0ssica (exoma), sin\u00f3 tamb\u00e9 interrogar-nos sobre les regions reguladores d’oncogens i gens supressors de tumors . Ongen H, Andersen CL, Bramsen JB, Oster B, Rasmussen MH, Ferreira PG, Sandoval J, Vidal I, Whiffin N, Planchon A, Padioleau I, Bielser D, Rom\u00e0 L, Tomlinson I, Houlston RS, Esteller M, Orntoft TF , Dermitzakis ET. Putative cis-regulatory drivers in colorectal cancer. Nature, DOI: 10.1038\/nature13602, 2014<\/p>\n","protected":false},"excerpt":{"rendered":" Refer\u00e8ncia de l’article<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-11 10:39:02","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8328"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8328"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8328\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8328"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8328"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8328"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/strong> <\/p>\n