Investigadors de l\u2019Institut Catal\u00e0 d\u2019Oncologia-Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (ICO-IDIBELL), liderats per David Garcia-Mollev\u00ed han identificat 5 gens expressats de forma diferencial en les c\u00e8l\u00b7lules normals acompanyants presents en els tumors colorectals. L\u2019an\u00e0lisi d\u2019aquests gens podria servir per classificar els tumors colorectals, predir quina ser\u00e0 l\u2019evoluci\u00f3 del pacient i en base aix\u00f2 prendre les decisions cl\u00edniques adequades per evitar recaigudes. <\/p>\n
El c\u00e0ncer colorectal \u00e9s el m\u00e9s freq\u00fcent a la nostra poblaci\u00f3 tenint en compte els dos sexes, amb uns 30.000 nous casos diagnosticats cada any. D\u2019aquests, aproximadament un 70% corresponen a estadis intermedis de la malaltia, i no existeixen criteris s\u00f2lids per a la indicaci\u00f3 de tractament afegit a la cirurgia en almenys la meitat dels casos. Per tant, \u00e9s de gran import\u00e0ncia identificar correctament aquells malalts que es beneficiaran d\u2019un tractament de quimioter\u00e0pia i poder aix\u00ed evitar els riscos afegits que comportaria el sobretractament. <\/p>\n
Per tal de poder identificar amb precisi\u00f3 les peculiaritats de cada tumor ens calen bons biomarcadors, que ens informin del pron\u00f2stic de cada pacient. En aquest sentit, tant les c\u00e8l\u00b7lules malignes com les c\u00e8l\u00b7lules normals acompanyants, que constitueixen un particular microambient, poden ser font d\u2019aquests biomarcadors. <\/p>\n
L\u2019investigador David Garcia-Mollev\u00ed que estudia el microambient tumoral a la recerca d\u2019aquests biomarcadors, forma part del grup d\u2019investigaci\u00f3 en quimioresist\u00e8ncia i factors predictors de resposta tumoral i medi ambient estromal de l\u2019ICO-IDIBELL ha coordinat aquest estudi que s\u2019ha publicat a la revista Oncotarget. <\/p>\n
En aquest estudi els investigadors han desenvolupat una eina a partir de l\u2019expressi\u00f3 de 5 gens caracter\u00edstics del microambient tumoral que permet classificar amb molta precisi\u00f3 el pron\u00f2stic de malalts afectats per c\u00e0ncer colorectal en un estadi intermedi de la malaltia. Garcia-Mollev\u00ed ha explicat que aquest nou treball representaa un pas endavant cap a una possible aplicaci\u00f3 cl\u00ednica d\u2019aquests resultats: \u201cHem aconseguit que l\u2019an\u00e0lisi conjunt de nom\u00e9s cinc gens, mitjan\u00e7ant t\u00e8cniques rutin\u00e0ries, ens proporcioni una informaci\u00f3 molt acurada sobre les probabilitats de recaiguda i sobre la idone\u00eftat d\u2019administrar tractament quimioter\u00e0pic a malalts en estadi II de la malaltia\u201d. <\/p>\n
Berdiel-Acer M., Berenguer A., Sanz-Pamplona R., Cuadras D., Sanjuan X., PaulesM.J., Santos C., Salazar R., Moreno V., Capella G., Villanueva A., Mollev\u00ed D.G. A 5-gene classifier from the carcinoma-associated fibroblast transcriptomic profile and clinical outcome in colorectal cancer. Oncotarget, 2014 Aug 30;5(15):6437-52.<\/p>\n","protected":false},"excerpt":{"rendered":"
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