Un estudi liderat pel grup de recerca en sarcomes de l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) dirigit per \u00d2scar Mart\u00ednez-Tirado demostra que els nivells de Caveolina-1 en rabdomiosracoma alveolar s\u00f3n indetectables o molt baixos i que la seva reintroducci\u00f3 gen\u00e8tica i reexpressi\u00f3, mitjan\u00e7ant f\u00e0rmacs epigen\u00e8tics, frena el creixement d\u2019aquests tumors. Els resultats s\u2019han publicat a la revista Oncotarget. <\/p>\n
El rabdomiosarcoma \u00e9s el sarcoma muscular m\u00e9s com\u00fa en nens i adolescents. Tot i els aven\u00e7os en la ter\u00e0pia, els pacients que presenten la variant anomenada rabdomiosarcoma alveolar tenen una superviv\u00e8ncia menor del 30% cinc anys despr\u00e9s del diagn\u00f2stic. <\/p>\n
L\u2019equip d\u2019\u00d2scar Mart\u00ednez-Tirado va estudiar el nivell d\u2019expressi\u00f3 de la prote\u00efna Caveolina-1 en diferents tipus de sarcoma. \u201cVam veure que les \u00faniques c\u00e8l\u00b7lules que no l\u2019expressaven o l\u2019expressaven molt poc eren les del rabdomiosarcoma alveolar i semblava que podien presentar alguna alteraci\u00f3 epigen\u00e8tica que impedia la seva expressi\u00f3\u201d explica l\u2019investigador. <\/p>\n
\u201cEn col\u00b7laboraci\u00f3 amb el Programa d\u2019Epigen\u00e8tica i Biologia del C\u00e0ncer de l\u2019IDIBELL, dirigit per Manel Esteller, vam analitzar els patrons de metilaci\u00f3 i v\u00e0rem veure que, efectivament, el promotor del gen de la caveolina estava silenciat per una hipermetilaci\u00f3, aix\u00ed que la prote\u00efna no es pot expressar\u201d. De manera que la caveolina-1 actua com a supressor de tumors. Quan els seus nivells s\u00f3n baixos o inexistents, es bloqueja la diferenciaci\u00f3 normal de les c\u00e8l\u00b7lules i facilita el desenvolupament del tumor. <\/p>\n
En el mercat existeixen f\u00e0rmacs que poden modificar les alteracions epigen\u00e8tiques. Els investigadors van testar un d\u2019aquests f\u00e0rmacs en l\u00ednees cel\u00b7lulars per tal de reactivar el promotor de la caveolina-1<\/p>\n
i promoure\u2019n de nou la seva expressi\u00f3. \u201cLa reintroducci\u00f3 de la caveolina\u201d explica Mart\u00ednez-Tirado \u201cprovoca que les c\u00e8l\u00b7lules tumorals tinguin m\u00e9s tend\u00e8ncia a diferenciar-se i, com que no poden recuperar l\u2019activitat normal acabin morint, frenant aix\u00ed el creixement del tumor\u201d. <\/p>\n
Els f\u00e0rmacs nom\u00e9s s\u2019han provat en cultius cel\u00b7lulars. Actualment, el grup de sarcomes treballa per esbrinar quins s\u00f3n els mecanismes moleculars que fan que la caveolina-1 freni el creixement del tumor per tal de poder traslladar la seva reintroducci\u00f3 mitjan\u00e7ant f\u00e0rmacs epigen\u00e8tics a la cl\u00ednica. <\/p>\n
En aquest estudi han col\u00b7laborat l\u2019IDIBELL, l\u2019Hospital de Sant Joan de D\u00e9u, l\u2019Hospital Vall d\u2019Hebron i l\u2019Institut de Medicina Predictiva i Personalitzada del C\u00e0ncer. <\/p>\n
Huertas-Mart\u00ednez J., Rello-Varona S., Herrero-Mart\u00edn D., Barrau I., Garc\u00eda-Moncl\u00fas S., S\u00e1inz-Jaspeado M., Lagares-Tena L., N\u00fa\u00f1ez-\u00c1lvarez Y., Mateo-Lozano S., Mora J.,Roma J., Toran N., Moran S., L\u00f3pez-Alemany R., Gallego S., Esteller M., Peinado M.A., Garc\u00eda del Muro X. and M. Tirado O. Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth. Oncotarget. 2014 Aug 27th Epub ahead of print.<\/p>\n","protected":false},"excerpt":{"rendered":"
F\u00e0rmacs epigen\u00e8tics Refer\u00e8ncia article<\/p>\n","protected":false},"author":6,"featured_media":10978,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-23 20:37:11","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8309"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8309"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8309\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10978"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8309"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8309"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8309"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}