El vincle entre humans i gossos \u00e9s fort i antic. Des de ser el protector dels primers ramats a un fidel animal de companyia, gossos i persones compartim molts aspectes de la vida. La relaci\u00f3 entre ambdues esp\u00e8cies ha estat estudiada per psic\u00f2legs, antrop\u00f2legs, et\u00f2legs i tamb\u00e9 per gen\u00e8tics i bi\u00f2legs moleculars. En aquest sentit, els gossos s\u00f3n un gran model per entendre les causes de les malalties humanes, especialment el c\u00e0ncer. <\/p>\n
A difer\u00e8ncia d’altres mam\u00edfers utilitzats en recerca, els gossos desenvolupen c\u00e0ncer espont\u00e0niament com els humans i \u00e9s la causa m\u00e9s freq\u00fcent de mort en aquesta esp\u00e8cie. El genoma del gos s’ha obtingut en els \u00faltims anys, per\u00f2 desconeixem encara com es controla i regula, el que denominem l\u2019epigenoma. <\/p>\n
Aquesta setmana l’equip dirigit per Manel Esteller, director del Programa d’Epigen\u00e8tica i Biologia del C\u00e0ncer (PEBC) de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), professor de Gen\u00e8tica de la Universitat de Barcelona i Investigador ICREA, ha caracteritzat l\u2019Epigenoma del gos i traslladat els resultats al c\u00e0ncer hum\u00e0 per entendre els canvis d’aspecte que pateixen els tumors. La troballa es publica aquesta setmana a la revista Cancer Research. <\/p>\n
“Hem caracteritzat l\u2019epigenoma a nivell de cada nucle\u00f2tid de l’ADN de c\u00e8l\u00b7lules procedents de l’esp\u00e8cie cocker spaniel. En aquestes c\u00e8l\u00b7lules canines hem indu\u00eft un canvi morfol\u00f2gic similar al que succeeix en la progressi\u00f3 del c\u00e0ncer i hem vist que apareixen alteracions importants en la modulaci\u00f3 dels gens, les anomenades lesions epigen\u00e8tiques\u201d comenta Manel Esteller. <\/p>\n
\u201cEl m\u00e9s interessant \u00e9s que quan hem mirat els mateixos gens de gos en c\u00e0ncer de mama hum\u00e0 les aberracions epigen\u00e8tiques succeeixen en les mateixes regions de l’ADN. Les dades indiquen l’exist\u00e8ncia de mecanismes epigen\u00e8tics comuns en ambdues esp\u00e8cies que han estat conservats evolutivament per canviar la forma i consist\u00e8ncia de les nostres c\u00e8l\u00b7lules i teixits\u201d conclou l’investigador. <\/p>\n
Els resultats de l\u2019estudi suggereixen que actuar farmacol\u00f2gicament sobre aquestes alteracions epigen\u00e8tiques podria ser \u00fatil per frenar la progressi\u00f3 de la malaltia. <\/p>\n
Refer\u00e8ncia de l\u2019article<\/strong> <\/p>\n A Comprehensive DNA Methylation Profile of Epithelial-to-Mesenchymal Transition. Carmona FJ, Davalos V, Vidal I, Gomez A, Heyn H, Hashimoto I, Vizoso M, Martinez-Cardus A, Sayols S, Ferreira H, Sanchez-Mut J, Moran S, Margeli M, Castella I, Berdasco M, Stefansson OA, Eyfjord JE, Gonzalez-Suarez I, Dopazo J, Orozco M, Gut I, Esteller M. Cancer Research, 2014<\/p>\n","protected":false},"excerpt":{"rendered":" Refer\u00e8ncia de l\u2019article<\/p>\n","protected":false},"author":6,"featured_media":10976,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8305","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-11-29 19:16:58","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8305","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8305"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8305\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10976"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8305"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8305"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8305"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}