La transcripci\u00f3 \u00e9s un dels mecanismes que s\u2019esdevenen a les c\u00e8l\u00b7lules i que permet llegir la informaci\u00f3 continguda en els gens. Un estudi encap\u00e7alat per la Unitat de Biomarcadors i Susceptibilitat del Programa de Prevenci\u00f3 i Control del C\u00e0ncer de l\u2019ICO-IDIBELL ha detectat grans difer\u00e8ncies en els programes de regulaci\u00f3 transcripcional de les c\u00e8l\u00b7lules normals i les c\u00e8l\u00b7lules de tumors de c\u00f2lon.<\/p>\n
En l\u2019estudi, que s\u2019ha publicat a la revista BMC Cancer<\/em>, els investigadors han comparat els perfils d\u2019expressi\u00f3 g\u00e8nica d\u2019un centenar de mostres de tumors de c\u00f2lon amb el de les seves cent parelles de teixit normal adjacent i han detectat difer\u00e8ncies en l\u2019activitat transcripcional i a la interacci\u00f3 entre els propis gens. Es conclou amb un missatge de p\u00e8rdua global de l\u2019activitat transcripcional a les c\u00e8l\u00b7lules tumorals de c\u00f2lon. Per\u00f2 d\u2019altra banda, per exemple, es descriuen uns pocs factors de transcripci\u00f3 que augmenten considerablement la seva activitat en les c\u00e8l\u00b7lules tumorals respecte a les normals.<\/p>\n L\u2019estudi obre la porta a una millor compressi\u00f3 de les alteracions en els programes que regulen la transcripci\u00f3 de les c\u00e8l\u00b7lules tumorals de c\u00f2lon.<\/p>\n Cordero D, Sol\u00e9 X, Crous-Bou M, Sanz-Pamplona R, Par\u00e9-Brunet L, Guin\u00f3 E, Olivares D, Berenguer A, Santos C, Salazar R, Biondo S, Moreno V. Large differences in global transcriptional regulatory programs of normal and tumor colon cells.. BMC Cancer. 2014 Sep 24;14:708. doi: 10.1186\/1471-2407-14-708.<\/p>\n","protected":false},"excerpt":{"rendered":" Refer\u00e8ncia de l\u2019article<\/p>\n","protected":false},"author":6,"featured_media":10972,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1,472],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-12 22:25:56","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8297"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8297"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8297\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10972"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8297"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8297"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8297"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}