{"id":8259,"date":"2014-12-12T00:00:00","date_gmt":"2014-12-11T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2014\/12\/12\/la-manipulacio-de-petits-arns-endogens-permet-recuperar-una-infertilitat-transgeneracional-progressiva-en-c-elegans\/"},"modified":"2020-05-13T19:47:51","modified_gmt":"2020-05-13T17:47:51","slug":"la-manipulacio-de-petits-arns-endogens-permet-recuperar-una-infertilitat-transgeneracional-progressiva-en-c-elegans","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2014\/12\/la-manipulacio-de-petits-arns-endogens-permet-recuperar-una-infertilitat-transgeneracional-progressiva-en-c-elegans\/","title":{"rendered":"La manipulaci\u00f3 de petits ARNs end\u00f2gens permet recuperar una infertilitat transgeneracional progressiva en C.elegans"},"content":{"rendered":"<p>Cada dia se\u2019n sap m\u00e9s sobre l\u2019estructura dels genomes i la seva influ\u00e8ncia en la regulaci\u00f3 de l\u2019expressi\u00f3 dels gens. En la investigaci\u00f3 dels components dels genomes, el model de nematode <em>C. elegans<\/em> \u00e9s pioner ja qu\u00e8 el seu genoma va ser el primer d\u2019un organisme multicel\u00b7lular a ser seq\u00fcenciat. <\/p>\n<p> L\u2019estudi publicat per la revista Cell Reports, \u00e9s el resultat de la col\u00b7laboraci\u00f3 de l\u2019equip de Juli\u00e1n Cer\u00f3n en el grup de Quimioresist\u00e8ncia i factors predictors de resposta tumoral i medi ambient estromal de l\u2019IDIBELL amb els grups de Ben Lehner i Juan Valc\u00e1rcel del <em>Centre de Regulaci\u00f3 Gen\u00f2mica<\/em> (CRG). Els investigadors han descrit la influ\u00e8ncia de gens antisentit i de petits ARN d\u2019interfer\u00e8ncia end\u00f2gens (siRNAs) en la regulaci\u00f3 del gen TOR, un gen altament conservat en eucariotes que regula el creixement i el metabolisme d\u2019organismes en resposta a nutrients. <\/p>\n<p>Els autors de l\u2019estudi han demostrat que aquest mecanisme influeix en la fertilitat de l\u2019animal. \u201cSi manipulem l\u2019expressi\u00f3 de TOR i el balan\u00e7 de les seves isoformes\u201d ha explicat Cer\u00f3n \u201csom capa\u00e7os de revertir la infertilitat que es transmet epigen\u00e8ticament entre generacions d\u2019animals mutats\u201d. <\/p>\n<p> <strong><\/p>\n<p><\/strong>Co-option of the piRNA Pathway for Germline-Specific Alternative Splicing of C. elegans TOR. Barber\u00e1n-Soler S, Fontrodona L, Rib\u00f3 A, Lamm AT, Iannone C, Cer\u00f3n J, Lehner B, Valc\u00e1rcel J. Cell Reports. 2014 Sep 10. pii: S2211-1247(14)00679-2.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Refer\u00e8ncia de l\u2019article<\/p>\n","protected":false},"author":6,"featured_media":10951,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-11 02:20:11","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8259"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8259"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8259\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10951"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8259"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8259"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}