La t\u00e8cnica es basa en l\u2019\u00fas de models ortot\u00f2pics (orthoxenograft\u00ae) de ratol\u00ed, mitjan\u00e7ant la implantaci\u00f3 de tumors humans en l\u2019\u00f2rgan corresponent del ratol\u00ed. Aix\u00ed, per exemple, quan es fa una bi\u00f2psia al pacient o se li extreu el tumor, es poden implantar les c\u00e8l\u00b7lules cancer\u00edgenes al mateix \u00f2rgan al ratol\u00ed. <\/p>\n
D\u2019aquesta manera, el model animal reprodueix les caracter\u00edstiques histol\u00f2giques, gen\u00e8tiques i epigen\u00e8tiques dels tumors humans, aix\u00ed com els patrons de disseminaci\u00f3 del tumor, cosa que no s’aconsegueix amb altres m\u00e8todes d’implantaci\u00f3. <\/p>\n
Per la seva banda, es pot aplicar el mateix tractament que rep el pacient al ratol\u00ed, i seguir-ne l\u2019evoluci\u00f3, la qual cosa obre la porta a valorar el risc de patir recaigudes aix\u00ed com el tractament m\u00e9s efica\u00e7 i amb menys efectes secundaris en cada cas, aconseguint una ter\u00e0pia personalitzada, ja que cada pacient tindria el seu model animal corresponent. <\/p>\n
L\u2019equip de l\u2019ICO-IDIBELL, en col\u00b7laboraci\u00f3 amb el CNIO de Madrid, i el Boston Children\u2019s Hospital ha aconseguit amb \u00e8xit obtenir models en c\u00e0ncer de c\u00f2lon, pulm\u00f3 i ovari.<\/p>\n","protected":false},"excerpt":{"rendered":"
La implantaci\u00f3 de c\u00e8l\u00b7lules cancer\u00edgenes del pacient en el mateix \u00f2rgan de ratolins permet reproduir amb molta precisi\u00f3 l\u2019evoluci\u00f3 i malignitat del tumor Models ortot\u00f2pics<\/p>\n","protected":false},"author":6,"featured_media":10945,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-05 06:58:36","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8249"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8249"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8249\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10945"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8249"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8249"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8249"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}