L\u2019Associaci\u00f3 Espanyola contra el C\u00e0ncer (AECC) va lliurar el passat 5 de febrer cinc ajuts a la recerca oncol\u00f2gica durant la celebraci\u00f3 de la tercera edici\u00f3 de la Nit Solid\u00e0ria que organitza anualment l\u2019entitat. Dos d\u2019aquests projectes han estat concedits a investigadors de l\u2019IDIBELL: Alberto Villanueva, cap del grup de quimioresist\u00e8ncia i factors predictors de resposta tumoral i medi ambient estromal de l\u2019ICO-IDIBELL i S\u00f2nia Guil, investigadora del grup d\u2019Epigen\u00e8tica i Biologia del C\u00e0ncer de l\u2019IDIBELL. <\/p>\n
El projecte d\u2019Alberto Villanueva que est\u00e0 cofinan\u00e7at per la Beca Campus Sanitas CIMA, es basa en la generaci\u00f3 de models precl\u00ednics avan\u00e7ats, anomenats orthoxenografts<\/em>, a partir de la implantaci\u00f3 de tumors de c\u00e0ncer d’ovari humans en rates at\u00edmiques. Aquests models seran b\u00e0sics per identificar les alteracions gen\u00e8tiques associades amb l’adquisici\u00f3 de resist\u00e8ncia alstractaments de quimioter\u00e0pia actuals, dentificar dianes terap\u00e8utiques que finalment s\u2019avaluaren com a estrat\u00e8gia de medicina personalitzada en els orthoxenografts <\/em>per tal de ser d’utilitat a l’hora de seleccionar el tractament d’aquestes pacients. <\/p>\n Actualment, la majoria de tumors d’ovari s\u00f3n tractats de forma homog\u00e8nia i al voltamt d’un 80% de les pacients adquireixen resist\u00e8ncia a aquests tractaments de quimioter\u00e0pia a trav\u00e9s de mecanismes moleculars. Aix\u00f2, juntament amb les baixes taxes de resposta als nous f\u00e0rmac en desenvolupament, posa de manifest la necessitat de desenvolupar noves ter\u00e0pies efectives per a aquestes pacients resistents. <\/p>\n D\u2019altra banda el projecte concedit a S\u00f2nia Guil se centra principalment en l’estudi de l’RNA, una mol\u00e8cula que no nom\u00e9s fa d’intermedi\u00e0ria entre els gens i les prote\u00efnes, sin\u00f3 que tamb\u00e9 tenen un paper regulador molt important a l’hora de “programar” la conducta de les nostres c\u00e8l\u00b7lules, tant en condicions normals com en disfuncions, i de manera especialment rellevant en el c\u00e0ncer. <\/p>\n Existeix un oncog\u00e8n, anomenat HMGA2 (molt abundant i determinant en la progressi\u00f3 del c\u00e0ncer de pulm\u00f3 i la seva met\u00e0stasi) l’efecte final del qual \u00e9s que les c\u00e8l\u00b7lules proliferin molt, de manera que el seu paper \u00e9sespecialment rellevant en el c\u00e0ncer de pulm\u00f3 de c\u00e8l\u00b7lula no petita (el m\u00e9s abundant i resistent a la quimioter\u00e0pia). Aquest efecte el realitza no nom\u00e9s com a prote\u00efna, sin\u00f3 tamb\u00e9 com RNA, revelant una faceta nova per HMGA2 com a oncog\u00e8n. <\/p>\n Els resultats inicials de l’estudi indiquen que, a m\u00e9s, hi ha un altre RNA (“RNAcomplementari”) que actua sobre el HMGA2 controlant aquesta faceta que incideix directament sobre el creixement cel\u00b7lular. Aquest RNA no es troba en totes les c\u00e8l\u00b7lules ni en tots els tumors de la mateixa manera, per tant la seva pres\u00e8ncia o no pres\u00e8ncia podria ser un indicador de la malignitat del tumor i se\u2019n podria predir l’agressivitat. <\/p>\n Els dos projectes tenen una durada de dos anys i compten amb un finan\u00e7ament de 20.000 euros cada un. En total l\u2019AECCha destinat 100.000 euros a cinc projectes de recerca oncol\u00f2gica.<\/p>\n","protected":false},"excerpt":{"rendered":" Control epigen\u00e8tic de la progressi\u00f3 tumoral<\/p>\n","protected":false},"author":6,"featured_media":10938,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-10 08:22:58","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8233"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8233"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8233\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10938"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8233"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8233"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8233"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}