Els receptors ionotr\u00f2pics de glutamat exerceixen nombroses funcions en el funcionament fisiol\u00f2gic de les sinapsis, i la seva desregulaci\u00f3 est\u00e0 associada a m\u00faltiples condicions neuropatol\u00f2giques. Cada cop existeixen m\u00e9s evid\u00e8ncies que indiquen que les subclasses d’aquests receptors (NMDA, AMPA o Kainat) s\u00f3n estructures din\u00e0miques que es mobilitzen entre el citosol i la membrana neuronal, on actuen com a canals de calci. Aix\u00f2 ha obert noves vies de recerca que tenen com a objectiu explicar com i per qu\u00e8 aquests receptors arriben a la membrana sin\u00e0ptica o a l\u2019abandonen. <\/p>\n
L\u2019investigador David Soto, del grup de recerca de Neurobiologia Cel\u00b7lular i Molecular, i el cap del subgrup de Neurobiologia dels receptors ionotr\u00f2pics de glutamat, Xavier Altafaj, han publicat recentment dos estudis independents a la revista Frontiers of Neuroscience. En llurs estudis, s\u2019han identificat nous reguladors moleculars de la neurotransmissi\u00f3 glutamat\u00e8rgica que poden contribuir a importants canvis de paradigma en el camp i, sobretot, ajudar a entendre les pertorbacions en el tr\u00e0nsit de receptors de glutamat implicats en la patog\u00e8nesi de les malalties neurol\u00f2giques. <\/p>\n
El treball del grup de Soto (Gratac\u00f3s-Batlle et al., <\/em>2015) descriu la carnitina palmitoiltransferasa 1C (CPT1C) com un nou regulador de l’expressi\u00f3 de superf\u00edcie de receptors AMPA (AMPARs) en neurones. La modulaci\u00f3 fina del tr\u00e0nsit a la membrana dels AMPARs \u00e9s fonamental en l’activitat sin\u00e0ptica normal i en processos de plasticitat sin\u00e0ptica. Els autors presenten CPT1C com a candidata per regular la fisiologia neuronal dels AMPARs. <\/p>\n D\u2019altra banda, l\u2019estudi publicat pel grup de Xavier Altafaj (Grau et al<\/em>., 2014) descriu la prote\u00efna quinasa DYRK1A com a un regulador directe dels receptors NMDA, i proposa un nou mecanisme per al control de la neurotransmissi\u00f3 glutamat\u00e8rgica a les neurones. En el context de la s\u00edndrome de Down (SD), patologia en la que el grup d\u2019Altafaj havia demostrat pr\u00e8viament el paper clau de DYRK1A i de la desregulaci\u00f3 dels receptors NMDAR (NMDARs), aquest estudi proporciona l’evid\u00e8ncia molecular, cel\u00b7lular i funcional que DYRK1A afecta directament NMDAR, obrint aix\u00ed noves vies per entendre i dissenyar estrat\u00e8gies terap\u00e8utiques. <\/p>\n Grau C, Arat\u00f3 K, Fern\u00e1ndez-Fern\u00e1ndez JM, Valderrama A,<\/p>\n Sindreu<\/p>\n C, Fillat C, Ferrer I, de la Luna S, Altafaj X. DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1\/GluN2A receptors.Front Cell Neurosci. 2014 Oct 17;8:331. doi: 10.3389\/fncel.2014.00331. <\/p>\n Gratac\u00f2s-Batlle E,<\/p>\n Yefimenko N,<\/p>\n Cascos-Garc\u00eda<\/p>\n H, Soto D.AMPAR interacting protein CPT1C enhances surface expression of GluA1-containing receptors. Front Cell Neurosci. 2015 Feb 2. doi: 10.3389\/fncel.2014.00469.<\/p>\n","protected":false},"excerpt":{"rendered":" Dos grups de l\u2019IDIBELL identifiquen nous reguladors dels receptors de glutamat que obren la porta a entendre diversos desordres neuronals Refer\u00e8ncies dels articles<\/p>\n","protected":false},"author":6,"featured_media":10936,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1,458],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-25 21:12:25","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8229"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8229"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8229\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10936"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8229"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8229"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8229"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}