Un estudi que publica la revista JAMA Oncology ha demostrat que una an\u00e0lisi de sang podria ser suficient per identificar la pres\u00e8ncia de mutacions espec\u00edfiques en tumors pulm\u00f3. Aix\u00f2 evitaria o reduiria significativament el nombre de bi\u00f2psies que caldria fer. <\/p>\n
L\u2019estudi ha estat liderat per Rafael Rosell, especialista en c\u00e0ncer de pulm\u00f3 de l\u2019ICO Badalona, i ha comptat amb la participaci\u00f3, entre d\u2019altres, de Felipe Cardenal, de l\u2019ICO L\u2019Hospitalet, Rut Porta, de l\u2019ICO Girona, i Enric Carcereny, Teresa Mor\u00e1n, Cristina Queralt, Itziar de Aguirre i Jos\u00e9 Luis Ram\u00edrez, de l\u2019ICO Badalona. El treball s\u2019ha realitzat amb el suport dels tres instituts de recerca implicats: l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) a l\u2019ICO L\u2019Hospitalet, l\u2019Institut Germans Trias i Pujol (IGTP) a Badalona, i l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Girona (IDIBGi), a Girona. <\/p>\n
En els darrers anys s\u2019ha avan\u00e7at molt en el tractament personalitzat del c\u00e0ncer, \u00e9s a dir, oferir una ter\u00e0pia en funci\u00f3 de les particularitats del seu tumor. En el cas del c\u00e0ncer de pulm\u00f3, per exemple, se sap que els pacients amb determinades mutacions en el gen EFGR responen b\u00e9 a inhibidors d\u2019aquest gen, com l\u2019erlotinib, que s\u2019ha convertit en el tractament d\u2019elecci\u00f3 en aquests casos. <\/p>\n
Per determinar per\u00f2, si el tumor t\u00e9 o no el gen mutat cal fer una o m\u00e9s bi\u00f2psies, per extreure una mostra suficient del tumor per ser analitzada gen\u00e8ticament. <\/p>\n
L\u2019estudi que publica JAMA Oncology, i que ha liderat el dr. Rafael Rosell, ha analitzat la sang perif\u00e8rica de 97 pacients amb mutacions en el gen EFGR, per veure si, mitjan\u00e7ant un test espec\u00edfic, el que es denomina bi\u00f2psia l\u00edquida, es podria detectar la pres\u00e8ncia d\u2019aquestes mutacions. <\/p>\n
El resultat ha estat positiu en el 78% de pacients. En aquests casos, doncs, no caldria fer la bi\u00f2psia convencional perqu\u00e8 l\u2019an\u00e0lisi de sang ja seria suficient per establir la conveni\u00e8ncia de tractar el malalt amb erlotinib. <\/p>\n
Aquestes an\u00e0lisis de sang no nom\u00e9s servirien per establir les mutacions inicials que t\u00e9 el tumor del pacient, sin\u00f3 per veure com evoluciona al llarg del tractament i si adquireix o no resist\u00e8ncia al medicament que est\u00e0 rebent. <\/p>\n
L\u2019estudi tamb\u00e9 ha servit per confirmar que no totes les mutacions en el gen EGFR ofereixen el mateix pron\u00f2stic. Aix\u00ed, s\u2019ha vist que una alteraci\u00f3 puntual en una zona del gen (l\u2019ex\u00f3 21) comporta un pitjor pron\u00f2stic que la deleci\u00f3 de l\u2019ex\u00f3 19. Aix\u00f2 indica la necessitat de millorar el tractament en els portadors d\u2019aquesta mutaci\u00f3.<\/p>\n","protected":false},"excerpt":{"rendered":"
Un estudi que publica la revista JAMA Oncology ha demostrat que una an\u00e0lisi de sang podria ser suficient per identificar la pres\u00e8ncia de mutacions espec\u00edfiques en tumors pulm\u00f3. Aix\u00f2 evitaria o reduiria significativament el nombre de bi\u00f2psies que caldria fer. L\u2019estudi ha estat liderat per Rafael Rosell, especialista en c\u00e0ncer de pulm\u00f3 de l\u2019ICO Badalona, […]<\/p>\n","protected":false},"author":6,"featured_media":10924,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-05 10:35:21","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8208"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8208"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8208\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10924"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8208"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8208"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8208"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}