Investigadors del grup de recerca en Gens i C\u00e0ncer de l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), liderats per Montse Sanchez-Cespedes, han identificat el gen PARD3 com a un supressor de tumors que est\u00e0 inactiu en c\u00e0ncer de pulm\u00f3 de tipus escam\u00f3s. Els resultats de l\u2019estudi s\u2019han publicat a la revista Cancer Research. <\/p>\n
Una correcta polaritzaci\u00f3 (orientaci\u00f3 en l\u2019espai) de les c\u00e8l\u00b7lules de<\/p>\n
l\u2019epiteli bronquial \u00e9s essencial per al manteniment i el desenvolupament adequat d\u2019aquest teixit en condicions normals. <\/p>\n
El gen PARD3 codifica per una prote\u00efna que regula la polaritzaci\u00f3 de les c\u00e8l\u00b7lules i les unions intercel\u00b7lulars. Quan el gen est\u00e0 inactivat, es produeixen errors en aquesta orientaci\u00f3 cel\u00b7lular i en el contacte amb les c\u00e8l\u00b7lules ve\u00efnes. \u201cQualsevol canvi que afecti aquesta estructura promou el desenvolupament de tumors\u201d ha explicat la investigadora Montse Sanchez-Cespedes. <\/p>\n
Mitjan\u00e7ant la restituci\u00f3 dels nivells de la prote\u00efna que codifica el gen PARD3, tant en l\u00ednies cel\u00b7lulars com en models animals de ratolins, es va observar que al regular de nou la polaritzaci\u00f3 de les c\u00e8l\u00b7lules es redu\u00efa significativament el risc de met\u00e0stasi. <\/p>\n
El c\u00e0ncer de pulm\u00f3 \u00e9s un dels tumors que presenta majors taxes de mortalitat a tot el m\u00f3n. Nom\u00e9s a Espanya moren cada any al voltant de 20.000 persones per aquesta causa. L’elevada taxa de mortalitat es deu principalment al diagn\u00f2stic avan\u00e7at de la malaltia, quan aquesta ja es troba en un estadi avan\u00e7at. <\/p>\n
La detecci\u00f3 tardana i la manca de ter\u00e0pies eficaces fan que la probabilitat de superviv\u00e8ncia dels pacients que tenen c\u00e0ncer de pulm\u00f3 sigui molt baixa. En conjunt, nom\u00e9s entre el 10% i el 15% dels pacients sobreviu m\u00e9s de 5 anys despr\u00e9s de la seva detecci\u00f3. L’origen de m\u00e9s del 80% dels casos \u00e9s el consum de tabac. El c\u00e0ncer de pulm\u00f3 de tipus escam\u00f3s i l\u2019adenocarcinoma pulmonar s\u00f3n els dos tipus de tumor pulmonar m\u00e9s freq\u00fcents. <\/p>\n
Refer\u00e8ncia de l’article<\/strong> <\/p>\n","protected":false},"excerpt":{"rendered":" La inactivaci\u00f3 del gen PARD3 promou la invasi\u00f3 de c\u00e8l\u00b7lules tumorals i la met\u00e0stasi Invasi\u00f3 tumoral i met\u00e0stasi El c\u00e0ncer de pulm\u00f3 Refer\u00e8ncia de l’article<\/p>\n","protected":false},"author":6,"featured_media":10912,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8186","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-11-29 17:48:26","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8186","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8186"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8186\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10912"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8186"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8186"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8186"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}