El grup de recerca de les neurofibromatosis de l\u2019Institut Catal\u00e0 d\u2019Oncologia (ICO), l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i l\u2019Institut de Medicicina Predictiva i Personalitzada del C\u00e0ncer (IMPPC) ha desenvolupat nous models en ratolins per a l\u2019estudi del principal tumor maligne associat a la neurofibromatosi del tipus 1. <\/p>\n
Els detalls del desenvolupament i la caracteritzaci\u00f3 dels nous models animals s\u2019han publicat a la revista EMBO Molecular Medicine. <\/p>\n
Les neurofibromatosis s\u00f3n trastorns del sistema nervi\u00f3s que afecten principalment al desenvolupament i creixement dels teixits de les c\u00e8l\u00b7lules neurals. <\/p>\n
La neurofibromatosi de tipus 1 n\u2019\u00e9s la variant m\u00e9s freq\u00fcent, ja que afecta a una de cada 3.500 persones, aproximadament. Est\u00e0 causada per mutacions al gen NF1, localitzat al cromosoma 17. L\u2019afectaci\u00f3 d\u2019aquest gen pot provocar un ventall molt divers de problemes de salut, com ara tumors a la pell i al sistema nervi\u00f3s. <\/p>\n
En aquest sentit, el principal tumor maligne associat a la neurofibromatosi tipus 1 \u00e9s l\u2019anomenat tumor maligne de la beina del nervi perif\u00e8ric. Pertany al grup de sarcomes de teixits tous, no n\u2019hi ha un tractament efectiu i est\u00e0 associat a una baixa superviv\u00e8ncia. <\/p>\n
L\u2019equip de l\u2019ICO-IDIBELL-IMPPC ha creat el que es denomina models ort\u00f2topics del tumor, \u00e9s a dir, han aconseguit amb \u00e8xit implantar el tumor hum\u00e0 en l\u2019\u00f2rgan corresponent del ratol\u00ed i que es desenvolupi com ho faria en la persona. <\/p>\n
L\u2019estudi d\u2019EMBO Molecular Medicine demostra aix\u00f2: que el model animal reprodueix les caracter\u00edstiques histol\u00f2giques, gen\u00e8tiques i epigen\u00e8tiques dels tumors humans, aix\u00ed com els patrons de disseminaci\u00f3 del tumor, cosa que no s’aconsegueix amb altres m\u00e8todes d’implantaci\u00f3. <\/p>\n
Fins a l\u2019actualitat no existien models animals basats en el transplantament directe de tumors primaris originats en aquest tipus de pacients. Aquest grup ha generat cinc models diferents utilitzant ratolins immunodeprimits als quals s\u2019ha implantat tumors maligne de la beina del nervi perif\u00e8ric en el mateix teixit on s\u2019originen els tumors en els humans. <\/p>\n
Aquests models animals permeten un millor estudi del tumor, aix\u00ed com promoure la medicina personalitzada. Donat el cas, es podria tenir un ratol\u00ed amb el tumor de cada pacient de manera que es pot preveure com es desenvolupar\u00e0 i decidir en cada cas quin ser\u00e0 el tractament m\u00e9s adequat per a cada pacient. <\/p>\n
Els primers assaigs han mostrat que el f\u00e0rmac sorafenib redueix el creixement tumoral en tots els models de ratol\u00ed i reforcen que es comenci a aplicar en la pr\u00e0ctica cl\u00ednica. <\/p>\n","protected":false},"excerpt":{"rendered":"
El grup de recerca de les neurofibromatosis de l\u2019Institut Catal\u00e0 d\u2019Oncologia (ICO), l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i l\u2019Institut de Medicicina Predictiva i Personalitzada del C\u00e0ncer (IMPPC) ha desenvolupat nous models en ratolins per a l\u2019estudi del principal tumor maligne associat a la neurofibromatosi del tipus 1. Els detalls del desenvolupament i la caracteritzaci\u00f3 […]<\/p>\n","protected":false},"author":6,"featured_media":10910,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8182","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-11-29 17:38:23","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8182","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8182"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8182\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10910"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8182"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8182"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8182"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}