Els gens solen expressar-se sempre com en l’escriptura occidental: d’esquerra a dreta en el nostre ADN. Aix\u00ed, quan parlem de l’activitat del nostre genoma, en realitat ens estem referint a l’expressi\u00f3 dels gens en aquest sentit de la doble cadena d’ADN. <\/p>\n
No obstant aix\u00f2, des de fa un temps, es coneix l’exist\u00e8ncia d’unes quantes seq\u00fc\u00e8ncies d’ADN ‘rebel’ que s’activen a l’inrev\u00e9s: de dreta a esquerra. S\u00f3n coneguts com transcrits antisentit. <\/p>\n
Se sap molt poc de les seves funcions, per\u00f2 avui un treball co-dirigit per Manel Esteller, director del Programa d’Epigen\u00e8tica i Biologia del C\u00e0ncer (PEBC) de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), Professor de Gen\u00e8tica de la Universitat de Barcelona i Investigador ICREA, i Sonia Guil del mateix departament, proporciona noves pistes i mecanismes per entendre les seves funcions i les seves alteracions en c\u00e0ncer. <\/p>\n
La troballa es publica en l’edici\u00f3 avan\u00e7ada de revista Proceedings of the National Academy of Sciences (PNAS). <\/p>\n
“Si imaginem una carretera per on tots els cotxes van en el mateix sentit, hem trobat un cotxe que va en sentit contrari i xoca contra un d’ells” explica Manel Estelller sobre el resultat de la investigaci\u00f3 publicada a PNAS . <\/p>\n
“Concretament” afegeix, “aquest transcrit antisentit regula a un gen expressat de forma m\u00e9s normal que es diu vimentina, associada al proc\u00e9s d’invasi\u00f3 tumoral. Tamb\u00e9 descrivim com en c\u00e0ncer de c\u00f2lon una alteraci\u00f3 epigen\u00e8tica trasbalsa aquest delicat equilibri de cotxes que van en diferents sentits per la mateixa via”. <\/p>\n
“Una altra dada rellevant de l’estudi \u00e9s la descripci\u00f3 per primera vegada d’un mecanisme molecular que explica com es mant\u00e9 tot aquest tr\u00e0fic creant un bucle tridimensional que permet la conviv\u00e8ncia i autoregulaci\u00f3 de gens que s’expressen en diferents sentits”, conclou la investigadora Sonia Guil. <\/p>\n
Els resultats derivats de la recerca desenvolupada a l’IDIBELL suposen tamb\u00e9 un avan\u00e7 en la recerca de nous biomarcadors de c\u00e0ncer i proporcionen les bases per a futures ter\u00e0pies contra les malalties humanes basades en el desenvolupament de mol\u00e8cules antisentit que puguin ser usades com a f\u00e0rmacs. <\/p>\n
Head-to-head antisense transcription and R-loop formation promotes transcriptional activation. Boque-Sastre R, Soler M, Oliveira-Mateos C, Portela A, Moutinho C, Sayols S, Villanueva A, Esteller M, Guil S. Proceedings of the National Academy of Sciences, doi \/ 10.1073 \/ pnas.1421197112, 2015<\/p>\n","protected":false},"excerpt":{"rendered":"
Cotxes en sentit contrari Refer\u00e8ncia de l’article<\/p>\n","protected":false},"author":6,"featured_media":8179,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8178","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-12-30 00:37:56","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8178","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8178"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8178\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/8179"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8178"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8178"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8178"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}