La met\u00e0stasi \u00e9s responsable del 90% de les morts en pacients amb c\u00e0ncer. Per aix\u00f2, entendre els mecanismes responsables d\u2019aquest proc\u00e9s \u00e9s un dels principals objectius de la recerca en c\u00e0ncer. La met\u00e0stasi consisteix en una s\u00e8rie de passos encadenats en els quals el tumor primari envaeix els teixits ve\u00efns i s\u2019acaba disseminant per tot l\u2019organisme.<\/p>\n
Un dels tumors amb major capacitat de produir met\u00e0stasi \u00e9s el melanoma, que ha incrementat la seva incid\u00e8ncia en les \u00faltimes d\u00e8cades, com a conseq\u00fc\u00e8ncia de la major exposici\u00f3 solar. <\/p>\n
Avui, un article publicat a la revista Nature Medicine dirigit per Manel Esteller, director del Programa d\u2019Epigen\u00e8tica i Biologia del C\u00e0ncer (PEBC) de l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), investigador ICREA i professor de gen\u00e8tica de la Universitat de Barcelona, descriu un mecanisme que explica com les c\u00e8l\u00b7lules tumorals s\u2019escapen del seu lloc d\u2019origen fent met\u00e0stasi i, a m\u00e9s, poden ser susceptibles a respondre a nous tractaments moleculars. <\/p>\n
\u201cHem comparat les c\u00e8l\u00b7lules dels tumors originals de pacients amb les c\u00e8l\u00b7lules que han fet met\u00e0stasi i hem vist que aquestes \u00faltimes presenten una alteraci\u00f3 espec\u00edfica en el seu material gen\u00e8tic. Concretament, activen un gen que est\u00e0 silenciat tant en les c\u00e8l\u00b7lules sanes com en les c\u00e8l\u00b7lules dels tumors primaris\u201d ha explicat Esteller. <\/p>\n
\u201cAquest gen\u201d continua l\u2019investigador \u201cs\u2019enc\u00e9n com una bombeta per guiar les c\u00e8l\u00b7lules tumorals que escapen del tumor primari\u201d. <\/p>\n
El gen, anomenat TBC1D16 s\u2019encarrega de modular oncogens molt potents com BRAF i EGFR i el que \u00e9s \u201cmolt interessant\u201d afirma Esteller \u201c\u00e9s que les met\u00e0stasis de melanoma es tornen \u2018addictes\u2019 a aquests oncogens de manera que els f\u00e0rmacs que els tenen com a diana, anomenats inhibidors de BRAF i MEK s\u00f3n m\u00e9s efectius\u201d. Segons explica Esteller \u201caquests estudis confirmen que els tumors humans canvien en la seva hist\u00f2ria natural adaptant-se a trav\u00e9s de la regulaci\u00f3 del seu genoma (per canvis epigen\u00e8tics) per sobreviure en els nous teixits on fan met\u00e0stasi. Per\u00f2, encara m\u00e9s rellevant, suggereixen que l\u2019\u00fas de tractaments combinats que no permeten a la c\u00e8l\u00b7lula tumoral adaptar-se s\u00f3n els m\u00e9s indicats per tractar la malaltia\u201d Refer\u00e8ncia article<\/strong> <\/p>\n Vizoso M, Ferreira HJ, Lopez-Serra P, Carmona FJ, Mart\u00ednez-Card\u00fas A, Girotti MR, Villanueva A, Guil S, Moutinho C, Liz J, Portela A,<\/p>\n Heyn H, Moran S, Vidal A, Martinez-Iniesta M, Manzano JL,<\/p>\n Fernandez-Figueras MT, Elez E, Mu\u00f1oz-Couselo E, Botella-Estrada R, Berrocal A, Pont\u00e9n F, van den Oord J, Gallagher WM, Frederick DT, Flaherty KT, McDermott U, Lorigan P, Marais R, Esteller M<\/span><\/strong>. Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR. Nature Medicine<\/em><\/strong>, doi: 10.1038\/nm.3863, 2015.<\/p>\n","protected":false},"excerpt":{"rendered":" Refer\u00e8ncia article Esteller M Nature Medicine<\/p>\n","protected":false},"author":6,"featured_media":10891,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-11 10:44:14","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8147"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8147"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8147\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10891"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8147"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8147"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}