Un consorci d’investigaci\u00f3 format pels hospitals Verge del Roc\u00edo de Sevilla, i Sant Joan de D\u00e9u i l’Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) de Barcelona, \u200b\u200bha trobat una nova alternativa terap\u00e8utica per als joves que pateixen un tumor pedi\u00e0tric maligne de os i parts toves denominat sarcoma d’Ewing. <\/p>\n
Els investigadors han combinat dos principis actius (Olaparib i Trabectedina), i han demostrat en models animals que millora la sensibilitat de les c\u00e8l\u00b7lules cancer\u00edgenes a aquests f\u00e0rmacs, el que sembla augmentar el seu efecte. De fet, han observat la remissi\u00f3 completa del c\u00e0ncer en el 100% dels casos per un per\u00edode molt prolongat. Els resultats de l’estudi s’han publicat a la revista Oncotarget. <\/p>\n
El Sarcoma d’Ewing, per\u00f2, t\u00e9 en l’actualitat una possibilitat de curaci\u00f3 inferior al 20% per a aquells pacients que presenten amb una malaltia disseminada (met\u00e0stasi) o que pateixen una recaiguda post-tractament. <\/p>\n
“Els nostres resultats demostren que la combinaci\u00f3 de Trabectedina i Olaparib podria suposar una nova estrat\u00e8gia terap\u00e8utica que hauria de ser estudiada en m\u00e9s profunditat perqu\u00e8 puguin beneficiar-se’n dels pacients d’aquesta malaltia en un futur pr\u00f2xim”, assegura Enrique d’\u00c0laba, director de la Unitat de Gesti\u00f3 Cl\u00ednica de Patologia de l’Hospital Verge del Roc\u00edo de Sevilla i del grup de Patologia Molecular del IBiS. <\/p>\n
S’ha observat com les c\u00e8l\u00b7lules del sarcoma d’Ewing necessiten mantenir els mecanismes de reparaci\u00f3 del dany de l’ADN en bones condicions per sobreviure i continuar dividint-se. “La Trabectedina, per\u00f2, provoca ruptures i alteraci\u00f3 de l’estructura de l’ADN de la c\u00e8l\u00b7lula cancerosa, per la qual cosa indueix a la mort cel\u00b7lular. I l\u2019Olaparib, treballa en la mateixa l\u00ednia, bloquejant l’acci\u00f3 d’un gen (PARP1), la funci\u00f3 \u00e9s reparar el dany en l’ADN quan detecta lesions “ha explicat el cap del grup de sarcomes de l’IDIBELL, \u00d2scar Mart\u00ednez Tirado. La combinaci\u00f3 d’ambd\u00f3s f\u00e0rmacs \u00e9s sin\u00e8rgica i aconsegueix eliminar el sistema de reparaci\u00f3 de l’ADN al complet, obtenint un efecte antitumoral molt m\u00e9s potent que l’aconseguit amb l’aplicaci\u00f3 de cada f\u00e0rmac de manera individual. <\/p>\n
L’Associaci\u00f3 Espanyola Contra el C\u00e0ncer (AECC) i l’Institut de Salut Carlos III han finan\u00e7at aquesta iniciativa dels doctors d’\u00c0laba, Jaume Mora, director del grup de recerca de biologia molecular dels tumors del desenvolupament de l’Hospital Sant Joan de D\u00e9u de Barcelona i \u00d2scar Mart\u00ednez Tirado, director del grup de sarcomes de l’IDIBELL. <\/p>\n
Ord\u00f3\u00f1ez JL, Amaral AT, Carcaboso AM, Herrero-Mart\u00edn D, Del Carmen Garc\u00eda-Mac\u00edas M, Sevillano V, Alonso D, Pascual-Pastura G, Sant-Segon L, Vila-Ubach M, Rodrigues T, Fraile S, Teodosio C , Maig-Iscar A, Aracil M, Galmarini CM, Tirado OM, Mora J, d’\u00c0laba E. The PARP inhibitor olaparib enhances the sensitivity of ewing sarcoma to trabectedin. Oncotarget. 2015 [Epub ahead of print]<\/p>\n","protected":false},"excerpt":{"rendered":"
Els investigadors han provat en ratolins una combinaci\u00f3 de dos principis actius que aconsegueix la remissi\u00f3 completa de la malaltia en tots els casos Combinaci\u00f3 eficient Refer\u00e8ncia de l’article<\/p>\n","protected":false},"author":6,"featured_media":8119,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8118","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-12-30 01:51:18","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8118","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8118"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8118\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/8119"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8118"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8118"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8118"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}