{"id":8112,"date":"2015-07-27T00:00:00","date_gmt":"2015-07-26T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2015\/07\/27\/una-proteina-conservada-des-de-bacteris-fins-a-humans-protegeix-dels-cops-de-calor\/"},"modified":"2020-05-29T11:24:38","modified_gmt":"2020-05-29T09:24:38","slug":"una-proteina-conservada-des-de-bacteris-fins-a-humans-protegeix-dels-cops-de-calor","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2015\/07\/una-proteina-conservada-des-de-bacteris-fins-a-humans-protegeix-dels-cops-de-calor\/","title":{"rendered":"Una prote\u00efna conservada des de bacteris fins a humans protegeix dels cops de calor"},"content":{"rendered":"

Investigadors de l’Institut de Recerca Biom\u00e8dica de Bellvitge (IDIBELL) a Barcelona, \u200b\u200bhan descobert que la prote\u00efna LSM-1 protegeix dels cops de calor als cucs Caernorhabditis elegans<\/em> que s’utilitzen com a model animal en la investigaci\u00f3. Nom\u00e9s els animals que tenen una major quantitat d’aquesta prote\u00efna sobreviuen a una pujada dr\u00e0stica de la temperatura. <\/p>\n

El grup que lidera Juli\u00e1n Cer\u00f3n a l’IDIBELL \u00e9s especialista en C. elegans<\/em>, un cuc mil\u00b7lim\u00e8tric que s’utilitza com a model animal en la investigaci\u00f3 biom\u00e8dica. <\/p>\n

En l’estudi que publica la revista RNA, l’investigador Eric Cornes va observar que els cucs transg\u00e8nics que tenien nivells elevats de LSM-1 eren m\u00e9s resistents als heat-shock, acabo en angl\u00e8s usat per definir una pujada brusca de la temperatura. Aquesta observaci\u00f3 va ser corroborada augmentant els nivells de LSM-1 de diferents maneres i els resultats eren consistents en tots els casos. Mentre una alta temperatura matava a la resta de cucs, els que tenies nivells alts de LSM-1 sobrevivien. <\/p>\n

“L’associaci\u00f3 d’aquests experiments amb les onades de calor estiuenques \u00e9s inevitable ja que la prote\u00efna LSM-1 est\u00e0 conservada des de bacteris fins humans” explica Juli\u00e1n Cer\u00f3n. <\/p>\n

Cada any milers de morts al m\u00f3n s\u00f3n atribu\u00efbles a les onades de calor. El 2003 a Europa van morir prop de 70.000 persones per aspectes relacionats amb les altes temperatures. I \u00e9s que moltes patologies es veuen empitjorades per la calor. A m\u00e9s, a la vista dels models de canvi clim\u00e0tic, l’impacte negatiu de la calor sobre la salut est\u00e0 lluny de remetre. <\/p>\n

Quan els investigadors van analitzar la seq\u00fc\u00e8ncia de la prote\u00efna LSM-1, van descobrir que aquesta ja existia en les formes de vida m\u00e9s antiga: els arqueobacteris. LSM-1 tamb\u00e9 t\u00e9 la funci\u00f3 de protegir als bacteris dels canvis en l’ambient. D’altra banda, en tumors humans s’ha descrit que aquesta prote\u00efna es troba present a nivells per sobre dels normals. Per tant, s\u2019hipotetitza que alts nivells d’aquesta prote\u00efna confereixen capacitat per sobreviure a c\u00e8l\u00b7lules i organismes en ambients desfavorables. <\/p>\n

“Hem relacionat a LSM-1 amb una ruta metab\u00f2lica que est\u00e0 present en tots els animals afirma l’investigador Juli\u00e1n Cer\u00f3n. “Per tant, confiem que aquest treball serveixi per establir les bases de noves l\u00ednies d’investigaci\u00f3 que aprofundeixin en la relaci\u00f3 d’aquesta prote\u00efna amb el metabolisme, la dieta, i la capacitat de sobreviure a altes temperatures” <\/p>\n

Refer\u00e8ncia<\/p>\n

<\/em> <\/p>\n

Cornes, E. Porta-de-la-Riva, M. Aristiz\u00e1bal-Corrales, D. Brokate-Plans, AM. Garc\u00eda-Rodr\u00edguez, FJ. Ertl, I. D\u00edaz, M. Fontrodona, L. Reis, K. Johnsen, R. Baillie, Sr. Mu\u00f1oz, MJ. Sarov, M. Dupuy, Sr. Cer\u00f3n, J. Cytoplasmic LSM-1 protein regulates stress responses through the insulin \/ IGF-1 signaling pathway in C. elegans. Publicat a Advance July 6, 2015, doi: 10.1261 \/ rna.052324.115. RNA 2015. <\/p>\n","protected":false},"excerpt":{"rendered":"

Protecci\u00f3 contra les altes temperatures i onades de calor<\/p>\n","protected":false},"author":6,"featured_media":8113,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,355],"tags":[],"class_list":["post-8112","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar","category-models-de-malaltia-en-c-elegans"],"publishpress_future_action":{"enabled":false,"date":"2024-11-29 23:40:32","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8112","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8112"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8112\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/8113"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8112"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8112"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8112"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}