L\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) ha llicenciat a l\u2019empresa Oxford Immunotec, una tecnologia per mesurar la secreci\u00f3 d\u2019anticossos anti-HLA de les c\u00e8l\u00b7lules B de mem\u00f2ria per tal de millorar l\u2019efici\u00e8ncia dels trasplantaments de rony\u00f3 aix\u00ed com d\u2019evitar el rebuig de l\u2019empelt.<\/p>\n
Oxford Immunotec \u00e9s una companyia biotecnol\u00f2gica centrada en el desenvolupament i comercialitzaci\u00f3 de noves proves innovadores en el camp de la immunologia que permetin una millor atenci\u00f3 al pacient i millorin la seva qualitat de vida.<\/p>\n
La tecnologia llicenciada ha estat desenvolupada per l\u2019equip d\u2019Oriol Bestard, investigador del grup de Nefrologia i trasplantament renal de l\u2019IDIBELL, cap de la Unitat de Trasplantament de rony\u00f3 de l\u2019Hospital Universitari de Bellvitge i professor de la Universitat de Barcelona. Els investigadors han publicat un estudi a la revista Kidney International on demostren l\u2019efic\u00e0cia d\u2019aquesta t\u00e8cnica en pacients en llista d\u2019espera per a un trasplantament de rony\u00f3 aix\u00ed com en pacients trasplantats que han patit rebuig per anticossos.<\/p>\n
Les persones tenim un sistema major d\u2019histocomptabilitat (HLA) propi, nom\u00e9s els bessons univitelins presenten el mateix HLA. En el camp del trasplantaments renals \u00e9s important trobar donants que siguin el m\u00e9s compatible possible amb el pacient i que no estiguin sensibilitzats, \u00e9s a dir que no tinguin anticossos preformats, dirigits contra els ant\u00edgens HLA de l\u2019\u00f2rgan estrany per tal d\u2019evitar el rebuig de l\u2019empelt i poder minimitzar els efectes secundaris dels tractaments immunosupressors.<\/p>\n
Actualment la \u00fanica via per avaluar aquesta sensibilitzaci\u00f3 immunol\u00f2gica \u00e9s mesurar els anticossos anti-HLA en sang per\u00f2 aquesta aproximaci\u00f3 no permet avaluar per complet la resposta de mem\u00f2ria. \u00c9s a dir, les c\u00e8l\u00b7lules B de mem\u00f2ria s\u00f3n capaces de convertir-se en c\u00e8l\u00b7lules secretores d\u2019anticossos contra el donant per\u00f2 no els secreten cont\u00ednuament.<\/p>\n
\u201cMesurar els anticossos que secreten les c\u00e8l\u00b7lules B de mem\u00f2ria espec\u00edfiques contra el donant com a resposta de mem\u00f2ria immunol\u00f2gica ens permet identificar si realment el pacient \u00e9s capa\u00e7 de generar anticossos contra l\u2019\u00f2rgan estrany tot i que no es trobin circulant pel torrent sanguini\u201d ha explicat Oriol Bestard.<\/p>\n
\u201cEs tracta d\u2019una t\u00e8cnica complement\u00e0ria que ens permetr\u00e0 afinar molt m\u00e9s la resposta que el pacient tindr\u00e0 en vers el trasplantament i potencialment tamb\u00e9 ajudar a decidir el tractament immunosupressor m\u00e9s adequat\u201d.<\/p>\n
L\u2019estudi s\u2019ha realitzat en 70 pacients i la llic\u00e8ncia gestionada per la Unitat d\u2019Innovaci\u00f3 de l\u2019IDIBELL permetr\u00e0 que Oxford Immunotec optimitzi aquesta tecnologia per tal de convertir-la en una eina aplicable a la cl\u00ednica. \u201cUn dels requisits per tirar endavant aquest eina\u201d diu Bestard \u201c\u00e9s confirmar la seva efic\u00e0cia amb m\u00e9s pacients en un estudi multic\u00e8ntric i internacional\u201d.<\/p>\n
El director executiu d\u2019Oxford Immunotec, Peter Wrighton-Smith,<\/p>\n
ha afirmat que \u201ctot i que encara queda una feina de desenvolupament important per tal de comercialitzar el test, la viabilitat t\u00e8cnica i el seu valor potencial ha quedat demostrat en l\u2019estudi publicat per Kidney International\u201d.<\/p>\n
L\u00facia M, Luque S, CrespoE, Melilli E, Cruzado JM, Martorell J, Jarque M,<\/p>\n
Gil-Vernet S, Manonelles A, Griny\u00f3JM, Bestard O. Preformed circulating HLA-specific memory B cells predict high risk of humoral rejection in kidney transplantation. Kidney International<\/em><\/p>\n advance online publication 15<\/p>\n July<\/p>\n 2015; doi: 10.1038\/ki.2015.205<\/p>\n","protected":false},"excerpt":{"rendered":" Refer\u00e8ncia de l\u2019article<\/p>\n","protected":false},"author":6,"featured_media":8111,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,339],"tags":[],"class_list":["post-8110","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar","category-nefrologia-i-transplantament-renal"],"publishpress_future_action":{"enabled":false,"date":"2024-11-12 17:20:23","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8110"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8110"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8110\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/8111"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8110"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8110"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}