El c\u00e0ncer de pulm\u00f3 de c\u00e8l\u00b7lula petita \u00e9s un tipus especial dins dels tumors que apareixen en aquests \u00f2rgans i constitueixen el 15% dels mateixos. Apareix gaireb\u00e9 exclusivament en fumadors i sol debutar a l’estadi de malaltia disseminada, \u00e9s a dir, amb la pres\u00e8ncia de met\u00e0stasi. Es caracteritza per respondre inicialment b\u00e9 a la quimioter\u00e0pia, per\u00f2 abans d’un any el tumor reapareix i baixa la superviv\u00e8ncia. <\/p>\n
En comparaci\u00f3 a la resta de tipus de c\u00e0ncer de pulm\u00f3, el de c\u00e8l\u00b7lula petita no disposa d’un tractament molecular personalitzat, en part perla dificultat d’obtenir material biol\u00f2gic per al seu estudi. Avui, un article publicat a Cancer Research, la revista oficial de la Societat Americana per a la Investigaci\u00f3 del C\u00e0ncer (AACR), dirigit per Manel Esteller, director del Programa d’Epigen\u00e8tica i Biologia del C\u00e0ncer de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), Investigador ICREA i Professor de Gen\u00e8tica de la Universitat de Barcelona, \u200b\u200bproporciona una informaci\u00f3 sobre una nova alteraci\u00f3 gen\u00e8tica en aquest tipus c\u00e0ncer de pulm\u00f3 que seria un bon candidat per al desenvolupament de f\u00e0rmacs espec\u00edfics. <\/p>\n
“Les nostres c\u00e8l\u00b7lules tenen dues c\u00f2pies de cada gen. I hem descobert que un 10% dels tumors de pulm\u00f3 de c\u00e8l\u00b7lula petita perden dues c\u00f2pies d’un gen anti-c\u00e0ncer denominat KAT6B” declara Manel Esteller, director de l’estudi. <\/p>\n
“El gen identificat origina una prote\u00efna que \u00e9s una histona acetiltransferasa, que ens podem imaginar que \u00e9s com una clau que obre el nostre ADN perqu\u00e8 s’expressin altres gens supressors de tumors. Quan falta en una c\u00e8l\u00b7lula, el seu ADN es tanca sobre si mateix i no deixa expressar-se a aquests gens protectors, accelerant el proc\u00e9s tumoral\u201d assenyala Esteller. \u201cSembla ser que aquestes c\u00e8l\u00b7lules tumorals a les que els falta aquest gen serien m\u00e9s sensibles a un f\u00e0rmac anomenat irinotecan que actua a nivell de l’ADN. Ens agradaria comprovar ara que els pacients amb aquesta alteraci\u00f3 tamb\u00e9 s\u00f3n m\u00e9s sensibles a aquest compost en futurs assajos. <\/p>\n
Simo-Riudalbas L, Perez-Salvia M, Setien F, Villanueva A, Moutinho C, Martinez-Cardus A, Moran S, Berdasco M, Gomez A, Vidal E, Soler M, Heyn H, Vaquero A, de la Torre C, Barcelo-Batllori S, Vidal A, Roz L, Pastorino U, Szakszon K, Borck G, Moura C, Carneiro F, Zondervan I, Savola S, Iwakawa R, Kohno T, Yokota J, Esteller M.<\/span><\/strong> KAT6B is a tumor suppressor histone H3 lysine 23 acetyltransferase undergoing genomic loss in small cell lung cancer. Cancer Research<\/em><\/strong>, pii: canres.3702.2014, 2015.<\/p>\n","protected":false},"excerpt":{"rendered":" Refer\u00e8ncia de l\u2019article Esteller M. Cancer Research<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8108","post","type-post","status-publish","format-standard","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-11-29 23:28:38","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8108","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8108"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8108\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8108"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8108"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}