{"id":8080,"date":"2015-10-08T00:00:00","date_gmt":"2015-10-07T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2015\/10\/08\/identifiquen-un-despertador-dun-oncogen-causant-de-leucemia\/"},"modified":"2020-05-13T19:47:27","modified_gmt":"2020-05-13T17:47:27","slug":"identifiquen-un-despertador-dun-oncogen-causant-de-leucemia","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2015\/10\/identifiquen-un-despertador-dun-oncogen-causant-de-leucemia\/","title":{"rendered":"Identifiquen un ‘despertador’ d’un oncog\u00e8n causant de leuc\u00e8mia"},"content":{"rendered":"

En els \u00faltims trenta anys s’han descrit en el camp de l’oncologia una gran quantitat de mutacions en gens implicats en m\u00faltiples vies cel\u00b7lulars. La capacitat actual de seq\u00fcenciar tot el material gen\u00e8tic d’un tumor ha provocat que s’hagin identificat un nombre encara m\u00e9s gran de mutacions en els tumors humans. No obstant aix\u00f2, sabem molt poc de quines s\u00f3n les conseq\u00fc\u00e8ncies per a l’activitat de les c\u00e8l\u00b7lules d’aquests canvis en l’estructura i composici\u00f3 de l’ADN.<\/span> <\/p>\n

Avui, un article publicat en Oncogene, dirigit per Manel Esteller, director del Programa d’Epigen\u00e8tica i Biologia del C\u00e0ncer de l\u2019IDIBELL, Investigador ICREA i Professor de Gen\u00e8tica de la Universitat de Barcelona, \u200b\u200bmostra com una mutaci\u00f3 en un gen t\u00e9 com a conseq\u00fc\u00e8ncia l’activaci\u00f3 d’un gen desencadenant de leuc\u00e8mia. <\/p>\n

“Recentment s’ha descobert l’exist\u00e8ncia de mutacions en el gen DNMT3A en leuc\u00e8mies. Semblava que la hist\u00f2ria s\u2019aturava aqu\u00ed. Per\u00f2 com aquest gen s’encarrega de silenciar altres gens que no han d’estar actius en la c\u00e8l\u00b7lula, ens vam preguntar quina seq\u00fc\u00e8ncia d’ADN estava sent “despertada” per la mutaci\u00f3 en les leuc\u00e8mies\u201d ha explicat Manel Esteller, director de l’estudi. <\/p>\n

“Analitzant tot el genoma de c\u00e8l\u00b7lules leuc\u00e8miques portadores de la mutaci\u00f3, ens vam adonar que el gen diana activat era el denominat oncog\u00e8n MEIS1. Es tracta d’un poder\u00f3s gen inductor de leuc\u00e8mia mieloide aguda del qual se sabia la seva funci\u00f3 proleuc\u00e8mica, per\u00f2 no com es posava en marxa. La mutaci\u00f3 de l’altre gen ho explica\u201d assenyala l’investigador. <\/p>\n

“Podem imaginar-lo com un castell de cartes. Si treus la carta de la fila inferior (DNMT3A) acaben caient totes les capes superiors, com \u00e9s el cas de l’oncog\u00e8n MEIS1. La troballa, a m\u00e9s de la seva utilitat en la predicci\u00f3 de pacients amb leuc\u00e8mies de mal pron\u00f2stic, suggereix que aquest subtipus de leuc\u00e8mia podria ser sensible a f\u00e0rmacs que tinguessin com a diana els dos gens estudiats”.<\/span> <\/p>\n

Ferreira HJ, Heyn H, Vizoso M, Moutinho C, Vidal I, Gomez A, Martinez-Cardus A, Simo-Riudalb\u00e0s L, Moran S, Jost I, Esteller M. DNMT3A Mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia. Oncogene, October 5th, 2015. <\/p>\n","protected":false},"excerpt":{"rendered":"

Refer\u00e8ncia de l\u2019article<\/p>\n","protected":false},"author":6,"featured_media":10851,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8080","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-11-29 17:41:51","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8080","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8080"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8080\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10851"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8080"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8080"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8080"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}