www.colonomics.org<\/a>). Encara que en una proporci\u00f3 menor, es van trobar tumors que havien perdut l’expressi\u00f3 del gen AMER1 mitjan\u00e7ant mecanismes de metilaci\u00f3 i de p\u00e8rdua de tot un bra\u00e7 cromos\u00f2mic. Aix\u00ed mateix, l’an\u00e0lisi de les dades d’expressi\u00f3 g\u00e8nica que ha perm\u00e8s caracteritzar fenot\u00edpicament les mostres estudiades suggereix que els tumors que perden expressi\u00f3 d’AMER1 pateixen una inactivaci\u00f3 de la via de Wnt. Aquesta troballa obre una via per seguir investigant el paper de AMER1 com a gen supressor tumoral en c\u00e0ncer de c\u00f2lon espor\u00e0dic. <\/p>\n En aquest estudi han participat investigadors de l’IDIBELL, l’ICO i del CNAG (Centre Nacional d’An\u00e0lisi Gen\u00f2mica), on es va dur a terme la seq\u00fcenciaci\u00f3 dels tumors i ha estat publicat a la revista Clinical Cancer Research. <\/p>\n
Sanz-Pamplona R, Lopez-Doriga A, Par\u00e9-Brunet L, L\u00e1zaro K, Bellido F, Alonso MH, Auss\u00f3 S, Guin\u00f3 E, Beltr\u00e1n S, Castro-Giner F, Gut M, Sanjuan X, Closa A, Cordero D, Mor\u00f3n-Duran FD, Soriano A, Salazar R, Valle L, Moreno V. Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer. <\/strong>Clinical Cancer Research<\/strong> 2015; 21(20):4709-18. doi: 10.1158\/1078-0432.CCR-15-0159<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"Sanz-Pamplona R, Lopez-Doriga A, Par\u00e9-Brunet L, L\u00e1zaro K, Bellido F, Alonso MH, Auss\u00f3 S, Guin\u00f3 E, Beltr\u00e1n S, Castro-Giner F, Gut M, Sanjuan X, Closa A, Cordero D, Mor\u00f3n-Duran FD, Soriano A, Salazar R, Valle L, Moreno V. Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer. Clinical Cancer Research 2015; 21(20):4709-18. doi: 10.1158\/1078-0432.CCR-15-0159<\/p>\n","protected":false},"author":6,"featured_media":10822,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-15 18:51:47","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8033"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8033"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8033\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10822"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8033"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8033"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8033"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}