{"id":8009,"date":"2016-01-20T00:00:00","date_gmt":"2016-01-19T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2016\/01\/20\/descoberta-una-base-epigenetica-comuna-en-totes-les-demencies\/"},"modified":"2020-05-13T19:47:20","modified_gmt":"2020-05-13T17:47:20","slug":"descoberta-una-base-epigenetica-comuna-en-totes-les-demencies","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2016\/01\/descoberta-una-base-epigenetica-comuna-en-totes-les-demencies\/","title":{"rendered":"Descoberta una base epigen\u00e8tica comuna en totes les dem\u00e8ncies"},"content":{"rendered":"<p>L&#8217;increment de l&#8217;esperan\u00e7a de vida en els pa\u00efsos occidentals ha fet aflorar, entre d\u2019altres, un augment dels casos diagnosticats de malalties neurodegeneratives, com serien les dem\u00e8ncies. Sabem molt poc de les bases cel\u00b7lulars i moleculars de les mateixes, i encara menys disposem de tractaments que tinguin un impacte real en el transcurs de la patologia. La m\u00e9s coneguda \u00e9s la malaltia d&#8217;Alzheimer, per\u00f2 altres dem\u00e8ncies rellevants en la nostra \u00e0rea s\u00f3n tamb\u00e9 l&#8217;associada a cossos de Lewy, la lligada a la malaltia de Parkinson i la que es pot desenvolupar a llarg termini en la S\u00edndrome de Down. \u00c9s interessant recon\u00e8ixer que totes elles tenen unes caracter\u00edstiques sota el microscopi similars, amb cert grau de superposici\u00f3 en els s\u00edmptomes cl\u00ednics, per la qual cosa podr\u00edem pensar que hi ha una base biol\u00f2gica compartida per totes elles. Avui, un article publicat a la revista<em> Translational Psychiatry<\/em>, la revista en psiquiatria traslacional de grup Nature, per Manel Esteller, director del Programa d&#8217;Epigen\u00e8tica i Biologia del C\u00e0ncer (PEBC) de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), Investigador ICREA i Professor de Gen\u00e8tica de la Universitat de Barcelona, mostra que les dem\u00e8ncies esmentades posseeixen totes elles un grup de gens inactivats qu\u00edmicament de forma comuna, per la qual cosa es demostra un mateix tronc inicial de la malaltia. <\/p>\n<p> <span class=\"TexteNivell4\"><\/p>\n<p><\/span><em>&#8220;Hem analitzat les marques qu\u00edmiques que determinen l&#8217;activitat del genoma, l&#8217;anomenat epigenoma, de la subst\u00e0ncia grisa 75 pacients amb diferents dem\u00e8ncies i hem comprovat com aquestes persones comparteixen una apagada o encesa err\u00f2nia d&#8217;un grup com\u00fa de 20 gens.&#8221;<\/em> \u2014comenta el Dr. Manel Esteller\u2014 <em>&#8220;I el que \u00e9s encara m\u00e9s excitant \u00e9s que alguns d&#8217;ells han estat trobats tamb\u00e9 per altres grups de forma independent, de manera que podrien ser gens veritablement implicats en el desenvolupament d&#8217;Alzheimer i de les dem\u00e8ncies en general. Entre els mateixos destaquen l\u2019Ankirina-1, implicada en els contactes entre c\u00e8l\u00b7lules, i Rhom2, relacionada amb els processos inflamatoris&#8221;<\/em> \u2014explica Dr Esteller, i conclou sobre la investigaci\u00f3\u2014 <em>&#8220;Ser\u00e0 ara important comen\u00e7ar a estudiar si aquests gens alterats poden ser diana de f\u00e0rmacs que s\u00f3n tan necessaris avui en dia per aquestes malalties de freq\u00fc\u00e8ncia creixent per a les quals disposem de molt poques opcions de tractament.&#8221;<\/em> <\/p>\n<p> <strong>Article<\/strong>: Sanchez-Mut JV, Heyn H, Vidal E, Moran S, Sayols S, Delgado-Morales R, Schultz MD, Ansoleaga B, Garcia-Esparcia P, Pons-Espinal M, Martinez de Lagran M, Dopazo J, Rabano A, Avila J, Dierssen M, Lott I, Ferrer I, Ecker JR, <strong><span style=\"text-decoration: underline;\">Esteller M<\/span><\/strong>. Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Article Esteller M Translational Psychiatry<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-08 22:08:56","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8009"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8009"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8009\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8009"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8009"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8009"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}