{"id":8008,"date":"2016-01-25T00:00:00","date_gmt":"2016-01-24T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2016\/01\/25\/c-elegans-com-a-model-en-lestudi-del-cancer-a-les-revistes-genetics-i-nature-medicine\/"},"modified":"2020-05-29T11:19:34","modified_gmt":"2020-05-29T09:19:34","slug":"c-elegans-com-a-model-en-lestudi-del-cancer-a-les-revistes-genetics-i-nature-medicine","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2016\/01\/c-elegans-com-a-model-en-lestudi-del-cancer-a-les-revistes-genetics-i-nature-medicine\/","title":{"rendered":"C. elegans com a model en l\u2019estudi del c\u00e0ncer, a les revistes Genetics i Nature Medicine"},"content":{"rendered":"<p>El nematode <em>Caernorhabditis elegans<\/em> s\u2019utilitza al laboratori del Dr. Juli\u00e1n Cer\u00f3n com a model d\u2019estudi de malalties. Aquest grup acaba de publicar dos treballs relacionats amb el c\u00e0ncer, un a <em>Genetics<\/em> i l\u2019altre a <em>Nature medicine<\/em>. <\/p>\n<p> L\u2019article publicat a <em>Genetics <\/em>\u00e9s fruit de la tesi doctoral de l\u2019estudiant austr\u00edaca Iris Ertl, dirigida pel Dr. Cer\u00f3n. La Iris i els seus col\u00b7laboradors han utilitzat t\u00e8cniques gen\u00e8tiques, transcript\u00f2miques i prote\u00f2miques per estudiar dues prote\u00efnes del complex SWI\/SNF que s\u00f3n mutuament excloents i que es troben conservades des dels llevats fins als humans. Les prote\u00efnes hom\u00f2logues humanes (SMARCD1, SMARCD2 i SMARCD3) s\u2019han trobat desregulades en diferents tipus de tumors, de manera que aquesta feina amb <em>C. elegans <\/em>ajuda a explicar l\u2019especificitat de les patologies relacionades amb aquestes prote\u00efnes, i suggereix l\u2019estudi d\u2019interaccions sint\u00e8tiques letals com aproximaci\u00f3 terap\u00e8utica. Una de les troballes m\u00e9s rellevants \u00e9s la interacci\u00f3 f\u00edsica i funcional entre components del complex SWI\/SNF i prote\u00efnes de l\u2019embolcall nuclear. <\/p>\n<p> Per una altra banda, en un treball encap\u00e7alat pel Dr. L\u00f3pez Ot\u00edn de la Universidad de Oviedo i publicat a <em>Nature Medicine,<\/em> s\u2019ha descobert que l\u2019alteraci\u00f3 de la prote\u00efna AIRAPL provoca neoplasmes proliferatius a trav\u00e9s d\u2019un mecanisme que dep\u00e8n de la via de senyalitzaci\u00f3 de la insulina. La Dra. Montserrat Porta, mitjan\u00e7ant la plataforma de <em>C. elegans<\/em>, ha realitzat assajos de longevitat i d\u2019interfer\u00e8ncia d\u2019RNA per demostrar que la relaci\u00f3 funcional entre la prote\u00efna AIRAPL i la via metab\u00f2lica de la insulina ja es d\u00f3na en cucs. Amb aquestes dades, <em>C. elegans<\/em> es posiciona com a model precl\u00ednic per a l\u2019estudi de l\u2019esmentada relaci\u00f3. <\/p>\n<p> Refer\u00e8ncies dels articles: <\/p>\n<p> Functional Interplay of Two Paralogs Encoding SWI\/SNF Chromatin-Remodeling Accessory Subunits During Caenorhabditis elegans Development. Ertl I, Porta-de-la-Riva M, G\u00f3mez-Orte E, Rubio K, Aristiz\u00e1bal-Corrales D, Cornes E, Fontrodona L, Osteikoetxea X, Ayuso C, Askjaer P, Cabello J, Cer\u00f3n J*. <strong><em>Genetics<\/em><\/strong>. 2016 Jan 6. pii: genetics.115.183533. <\/p>\n<p> Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling. Osorio FG, Soria-Valles C, Santiago-Fern\u00e1ndez O, Bernal T,2, Mittelbrunn M, Colado E, Rodr\u00edguez F, Bonzon-Kulichenko E, V\u00e1zquez J, <strong>Porta-de-la-Riva M, Cer\u00f3n J,<\/strong> Fueyo A Li J, Green AR1, Freije JM, L\u00f3pez-Ot\u00edn C. <strong>Nature Medicine. <\/strong>2016 Jan;22(1):91-6.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Genetics Porta-de-la-Riva M, Cer\u00f3n J, Nature Medicine.<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1,355],"tags":[],"class_list":["post-8008","post","type-post","status-publish","format-standard","hentry","category-sin-categorizar","category-models-de-malaltia-en-c-elegans"],"publishpress_future_action":{"enabled":false,"date":"2025-03-02 13:41:06","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8008","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8008"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8008\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8008"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8008"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8008"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}