{"id":8000,"date":"2016-02-12T00:00:00","date_gmt":"2016-02-11T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2016\/02\/12\/eva-gonzalez-suarez-obte-una-consolidator-grant-de-leuropean-research-council\/"},"modified":"2020-05-13T19:47:17","modified_gmt":"2020-05-13T17:47:17","slug":"eva-gonzalez-suarez-obte-una-consolidator-grant-de-leuropean-research-council","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2016\/02\/eva-gonzalez-suarez-obte-una-consolidator-grant-de-leuropean-research-council\/","title":{"rendered":"Eva Gonz\u00e1lez Su\u00e1rez obt\u00e9 una Consolidator Grant de l&#8217;European Research Council"},"content":{"rendered":"<p><strong>La cap del grup de Transformaci\u00f3 i Met\u00e0stasi del PEBC-IDIBELL, Eva Gonz\u00e1lez Su\u00e1rez, ha rebut una ERC Consolidator Grant de l&#8217;European Research Council (ERC) per desenvolupar el seu projecte PLEIO-RANK dirigit a desenvolupar una ter\u00e0pia \u00fanica capa\u00e7 de reduir la met\u00e0stasi i la mortalitat en tumors s\u00f2lids. La beca suposa un finan\u00e7ament de 2 milions d&#8217;Euros per als propers cinc anys.<\/strong> <\/p>\n<p> Milers de pacients de c\u00e0ncer a tot el m\u00f3n estan prenent inhibidors de RANKL per al maneig de les met\u00e0stasis \u00f2ssies, basat en el paper clau de RANKL i el seu receptor, RANK, en els osteoclasts. &#8220;Hem demostrat&#8221; explica la investigadora &#8220;que la sobreexpressi\u00f3 de RANK indueix stemness, interfereix en la diferenciaci\u00f3 en c\u00e8l\u00b7lules epitelials mam\u00e0ries no transformades i promou els primers passos de la tumorog\u00e8nesi mam\u00e0ria actuant com un mediador paracr\u00ed de la progesterona&#8221;. <\/p>\n<p> &#8220;El projecte PLEIO-RANK&#8221; afegeix &#8220;pret\u00e9n explorar el potencial terap\u00e8utic de la inhibici\u00f3 de la senyalitzaci\u00f3 de RANK en altres tumors s\u00f2lids, no nom\u00e9s com una estrat\u00e8gia preventiva, sin\u00f3 tamb\u00e9 durant la progressi\u00f3 del tumor, recurr\u00e8ncia i met\u00e0stasi. Anem a disseccionar el paper d&#8217;aquesta via en les c\u00e8l\u00b7lules tumorals i en l&#8217;estroma circumdant&#8221;. La inhibici\u00f3 de RANK podria convertir-se en una ter\u00e0pia \u00fanica dirigida a reduir la met\u00e0stasi i la mortalitat en els tumors s\u00f2lids pels seus efectes antitumorals pleiotr\u00f2pics en les c\u00e8l\u00b7lules canceroses i l&#8217;estroma. <\/p>\n<p> Les Consolidator Grants tenen com a objectiu impulsar la carrera d&#8217;investigadors amb talent i visi\u00f3 innovadora que hagin demostrat el seu potencial investigador i la seva maduresa cient\u00edfica. <\/p>\n<p> <a class=\"enllac\" href=\"https:\/\/erc.europa.eu\/media-and-events\/press-releases\">Enlla\u00e7 a la informaci\u00f3 difosa per l&#8217;ERC<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>La cap del grup de Transformaci\u00f3 i Met\u00e0stasi del PEBC-IDIBELL, Eva Gonz\u00e1lez Su\u00e1rez, ha rebut una ERC Consolidator Grant de l&#8217;European Research Council (ERC) per desenvolupar el seu projecte PLEIO-RANK dirigit a desenvolupar una ter\u00e0pia \u00fanica capa\u00e7 de reduir la met\u00e0stasi i la mortalitat en tumors s\u00f2lids. La beca suposa un finan\u00e7ament de 2 milions d&#8217;Euros per als propers cinc anys.<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8000","post","type-post","status-publish","format-standard","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-11-30 10:29:05","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8000","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=8000"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/8000\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=8000"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=8000"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=8000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}