La via de senyalitzaci\u00f3 de la fosfatidilinositol 3-quinasa (PI3K) \u00e9s clau en multitud de processos biol\u00f2gics que controlen el metabolisme, la s\u00edntesi de prote\u00efnes, el creixement, la superviv\u00e8ncia i la migraci\u00f3 cel\u00b7lular. Aix\u00f2 porta inevitablement a la participaci\u00f3 d\u2019aquesta via en determinats processos inflamatoris com tamb\u00e9 en diferents malalties, com la diabetis i el c\u00e0ncer, on aquesta via s\u2019altera en almenys el 80% dels c\u00e0ncers humans. \u00c9s per aix\u00f2 que les PI3Ks es postulen com a importants dianes per al descobriment de noves ter\u00e0pies. <\/p>\n
\u00c9s necess\u00e0ria la implicaci\u00f3 d\u2019un ampli espectre de capacitats tecnol\u00f2giques i cient\u00edfiques per poder desxifrar en detall com funcionen les diferents PI3Ks, i \u00e9s per aquest motiu que diferents grups acad\u00e8mics, cl\u00ednics i industrials europeus experts en l\u2019estudi de les PI3K s\u2019han unit per formar la xarxa de formaci\u00f3:<\/p>\n
“Phd: Desxifrant la biologia de <\/em><\/strong>PI3K en la salut i en la malaltia<\/em><\/strong>“. Aquest projecte est\u00e0 finan\u00e7at pel programa d\u2019investigaci\u00f3 i innovaci\u00f3 Horizon 2020 de la Uni\u00f3 Europea sota l\u2019acord Marie Sk\u0142odowska-Curie n\u00fam. 675392. La xarxa de doctorat t\u00e9 com a objectiu final reunir les compet\u00e8ncies, eines i coneixements necessaris per formar una nova generaci\u00f3 d\u2019investigadors en la fase inicial de la seva carrera (ESR), i preparar-los per afrontar el lideratge de la investigaci\u00f3 i el descobriment de f\u00e0rmacs en la ind\u00fastria europea i en el m\u00f3n acad\u00e8mic. Un total de 15 ESR participaran en aquest programa multidisciplinari i intersectorial de recerca i formaci\u00f3 que permetr\u00e0 explorar, mitjan\u00e7ant la tecnologia m\u00e9s innovadora, tots els camps de la fam\u00edlia de les PI3Ks i de les seves vies de senyalitzaci\u00f3, tant en situacions fisiol\u00f2giques com patol\u00f2giques. <\/p>\n Mariona Graupera, cap del grup de Vies de Senyalitzaci\u00f3 en Angiog\u00e8nesi de l\u2019IDIBELL, \u00e9s la coordinadora del projecte. El consorci est\u00e0 format per deu beneficiaris de sis pa\u00efsos europeus diferents: IDIBELL, Espanya; University College London (UCL), Regne Unit; Forschungsverbund Berlin E.V (FVB-FMP), Alemanya; The Babraham Institute (BI), Regne Unit; Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Fran\u00e7a; Centre Europ\u00e9en de Recherche en Biologie et M\u00e9decine (CERBM-GIE), Fran\u00e7a; Fundaci\u00f3 Privada Institut d\u2019Investigaci\u00f3 Oncol\u00f2gica Vall d\u2019Hebron (VHIO), Espanya; Universit\u00e0 degli Studi di Torino (UNITO), It\u00e0lia; Universit\u00e4t Basel (UNIBASEL), Su\u00efssa, i ARIVIS AG, Alemanya. <\/p>\n El projecte va comen\u00e7ar l\u20191 de novembre del 2015 i el 13 de gener del 2016 va tenir lloc la primera reuni\u00f3 de la xarxa Phd. Aquesta primera trobada, punt de partida oficial del projecte, es va fer a l\u2019Institut d\u2019Estudis Catalans de Barcelona, i va servir per assegurar que tots els participants tinguessin una visi\u00f3 completa dels objectius i de l\u2019estructura del projecte, i per establir unes bones relacions de treball entre els membres del projecte.<\/p>\n","protected":false},"excerpt":{"rendered":" Phd: Desxifrant la biologia de PI3K en la salut i en la malaltia<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7998","post","type-post","status-publish","format-standard","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2025-01-01 11:31:27","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7998","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7998"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7998\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7998"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7998"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7998"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}