{"id":7955,"date":"2016-08-18T00:00:00","date_gmt":"2016-08-17T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2016\/08\/18\/no-totes-les-cel%e2%80%a2lules-dun-tumor-son-iguals\/"},"modified":"2020-05-13T19:47:10","modified_gmt":"2020-05-13T17:47:10","slug":"no-totes-les-cel%e2%80%a2lules-dun-tumor-son-iguals","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2016\/08\/no-totes-les-cel%e2%80%a2lules-dun-tumor-son-iguals\/","title":{"rendered":"No totes les c\u00e8l\u2022lules d&#8217;un tumor s\u00f3n iguals"},"content":{"rendered":"<p>Un nou estudi liderat pel Dr. Manel Esteller, director del Programa d&#8217;Epigen\u00e8tica i Biologia del C\u00e0ncer (PEBC) de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), Investigador ICREA i Professor de Gen\u00e8tica de la Universitat de Barcelona (UB), descobreix que els tumors colorectals presenten heterogene\u00eftat epigen\u00e8tica que es relaciona amb el curs cl\u00ednic de la malaltia. L&#8217;article que descriu la troballa ha estat publicat a la revista <em>Gastroenterology<\/em>, la m\u00e9s prestigiosa en l&#8217;\u00e0rea de les malalties de l&#8217;aparell digestiu i \u00f2rgan oficial d&#8217;expressi\u00f3 de la Societat Americana de Gastroenterologia. <\/p>\n<p> Els tumors humans estan adaptats per cr\u00e9ixer a un ritme exponencial dins del pacient, disposant a m\u00e9s a m\u00e9s de la capacitat per adaptar-se i sobreviure als canvis ambientals que puguin patir, com seria per exemple l&#8217;administraci\u00f3 de quimioter\u00e0pia o radioter\u00e0pia. Part d&#8217;aquesta habilitat es creu que es deu a l&#8217;exist\u00e8ncia de diversos tipus de c\u00e8l\u00b7lules canceroses dins d&#8217;un mateix tumor: \u00e9s el concepte que es coneix com heterogene\u00eftat. <\/p>\n<p> En aquest sentit, els primers estudis ja comen\u00e7aven a demostrar l&#8217;exist\u00e8ncia d&#8217;algunes lesions gen\u00e8tiques diferents a nivell intratumoral. No obstant aix\u00f2, es desconeixia si els canvis epigen\u00e8tics, \u00e9s a dir, les alteracions de l&#8217;activitat dels gens, que s\u00f3n molt m\u00e9s din\u00e0miques, tamb\u00e9 podien ser heterog\u00e8nies. <\/p>\n<p> &#8220;<em>En pacients amb c\u00e0ncer colorectal, hem determinat l&#8217;epigenoma de tres regions de cada tumor individual: la zona que mira a la llum del tub digestiu, la zona central i la que creix cap als vasos sanguinis. Els resultats demostren l&#8217;exist\u00e8ncia d&#8217;heterogene\u00eftat intratumoral, el qu\u00e8 significa que cada regi\u00f3 presenta difer\u00e8ncies<\/em>&#8220;, comenta el Dr. Manel Esteller. &#8220;<em>La regi\u00f3 epigen\u00e8ticament m\u00e9s diferent \u00e9s el front invasiu, la zona que interacciona amb els teixits normals adjacents. Tamb\u00e9 hem vist que la regi\u00f3 intratumoral m\u00e9s semblant a les met\u00e0stasi dels pacients \u00e9s la m\u00e9s antiga del tumor, cosa que indica la possible pres\u00e8ncia de disseminaci\u00f3 fins i tot en estadis aparentment primerencs\u201d.<\/em> <em><br \/><\/em> L&#8217;heterogene\u00eftat intratumoral a nivell epigen\u00e8tic tamb\u00e9 pot tenir aplicacions a nivell pron\u00f2stic, explica Esteller: &#8220;A m\u00e9s, les dades reflecteixen que com m\u00e9s s&#8217;assemblen les tres regions, m\u00e9s agressivitat demostra el tumor, com si s&#8217;hagu\u00e9s seleccionat a la poblaci\u00f3 cel\u00b7lular amb m\u00e9s capacitat de proliferaci\u00f3. Els estudis del nivell d&#8217;heterogene\u00eftat molecular dels tumors podrien aix\u00ed ser usats com a predictors del pron\u00f2stic dels mateixos i del seu potencial per adquirir resist\u00e8ncies a les ter\u00e0pies&#8221;. <\/p>\n<p> <strong>Refer\u00e8ncia de l&#8217;article<\/strong> <strong><\/p>\n<p><\/strong> <em>Mart\u00ednez-Card\u00fas A, Moran S, Musulen E, Moutinho C, Manzano JL, Martinez-Balibrea E, Tierno M, \u00c9lez E, Landolfi S, Lorden P, Arribas C, M\u00fcller B, Bock C, Tabernero J, <strong><span style=\"text-decoration: underline;\">Esteller M<\/span><\/strong>. Epigenetic homogeneity within colorectal tumors predicts shorter relapse-free and overall survival times for patients with loco-regional cancer. <\/em><strong><em>Gastroenterology<\/em><\/strong><em>, doi: 10.1053\/j.gastro.2016.08.0012016, 2016.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Demostren que els tumors colorectals presenten heterogene\u00eftat epigen\u00e8tica que es relaciona amb el curs cl\u00ednic de la malaltia. Refer\u00e8ncia de l&#8217;article  Esteller M Gastroenterology<\/p>\n","protected":false},"author":6,"featured_media":10763,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7955","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-12-30 12:09:06","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7955","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7955"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7955\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10763"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7955"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7955"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7955"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}