{"id":7946,"date":"2016-09-06T00:00:00","date_gmt":"2016-09-05T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2016\/09\/06\/el-microambient-tumoral-un-mecanisme-de-resistencia-al-tractament-amb-quimioterapia-en-cancer-colorrectal\/"},"modified":"2020-05-13T19:47:09","modified_gmt":"2020-05-13T17:47:09","slug":"el-microambient-tumoral-un-mecanisme-de-resistencia-al-tractament-amb-quimioterapia-en-cancer-colorrectal","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2016\/09\/el-microambient-tumoral-un-mecanisme-de-resistencia-al-tractament-amb-quimioterapia-en-cancer-colorrectal\/","title":{"rendered":"El microambient tumoral, un mecanisme de resist\u00e8ncia al tractament amb quimioter\u00e0pia en c\u00e0ncer colorrectal"},"content":{"rendered":"<p>Investigadors de l&#8217;Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) han publicat a <em>Oncotarget <\/em>un nou treball que posa de manifest la import\u00e0ncia de l&#8217;entorn del tumor com a generador de resist\u00e8ncia al tractament del c\u00e0ncer colorrectal, el quart c\u00e0ncer m\u00e9s freq\u00fcent i la principal causa de mortalitat per c\u00e0ncer a tot el m\u00f3n. L&#8217;article descriu com la pres\u00e8ncia de certes mol\u00e8cules a l&#8217;entorn del tumor desencadena processos que protegeixen les c\u00e8l\u00b7lules tumorals de l&#8217;acci\u00f3 de la quimioter\u00e0pia convencional. Aquesta resist\u00e8ncia al tractament \u00e9s un dels principals obstacles als quals els pacients s&#8217;enfronten durant el curs de la malaltia; per aix\u00f2, entendre els mecanismes a trav\u00e9s dels quals es genera \u00e9s b\u00e0sic per millorar el pron\u00f2stic. <\/p>\n<p> L&#8217;estudi, liderat pel Dr. David G. Mollev\u00ed, del Programa contra la resist\u00e8ncia terap\u00e8utica en c\u00e0ncer (PROCURE) de l\u2019IDIBELL, demostra com algunes citoquines, quimioquines i d\u2019altres mol\u00e8cules solubles secretades pels fibroblasts associats a carcinoma (CAF), un tipus de c\u00e8l\u00b7lules no tumorals estretament associades amb les tumorals, indueixen processos que alenteixen el cicle cel\u00b7lular, afectant la proliferaci\u00f3 de c\u00e8l\u00b7lules tumorals. En pres\u00e8ncia de quimioter\u00e0pia convencional, aquestes mol\u00e8cules estabilitzen i activen prote\u00efnes de senyalitzaci\u00f3 que dificulten l&#8217;efectivitat del tractament. No obstant, els investigadors tamb\u00e9 han observat que la inhibici\u00f3 de la via de senyalitzaci\u00f3 JAK\/STAT, addicta a moltes d\u2019aquestes citoquines sembla revertir aquest efecte protector. <\/p>\n<p> La import\u00e0ncia de microambient tumoral en progressi\u00f3 del c\u00e0ncer i el seu paper en el desenvolupament de resist\u00e8ncia a les ter\u00e0pies \u00e9s una possibilitat cada cop m\u00e9s evident per als investigadors. &#8220;Encara que la recerca actual en c\u00e0ncer se centra principalment en les ter\u00e0pies contra objectius espec\u00edfics, la majoria dels tumors encara s\u00f3n tractats amb ter\u00e0pies convencionals, de manera que la resist\u00e8ncia als medicaments segueix sent el principal obstacle per a l\u2019\u00e8xit&#8221;, explica el Dr. Mollev\u00ed. <\/p>\n<p> &#8220;Des d&#8217;una perspectiva cl\u00ednica, la identificaci\u00f3 dels factors que intervenen en aquest tipus de<\/p>\n<p> resist\u00e8ncia a medicaments podria aportar informaci\u00f3 \u00fatil per evitar-la&#8221;, comenta l\u2019investigador de l\u2019IDIBELL, i afegeix: &#8220;Si obstaculitzem l&#8217;acci\u00f3 d&#8217;aquelles c\u00e8l\u00b7lules normals responsables de la s\u00edntesi d&#8217;aquests factors, \u00e9s possible que puguem evitar l&#8217;efecte protector exercit per les mol\u00e8cules secretades, cosa que tornaria les c\u00e8l\u00b7lules tumorals sensibles a la quimioter\u00e0pia&#8221;.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un nou treball posa de manifest la import\u00e0ncia de l&#8217;entorn  del tumor com a generador de resist\u00e8ncia al tractament del c\u00e0ncer  colorrectal, el quart c\u00e0ncer m\u00e9s freq\u00fcent i la principal causa de  mortalitat per c\u00e0ncer a tot el m\u00f3n.<\/p>\n","protected":false},"author":6,"featured_media":10758,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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