{"id":7929,"date":"2016-09-20T00:00:00","date_gmt":"2016-09-19T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2016\/09\/20\/demostren-lefectivitat-duna-nova-combinacio-de-farmacs-en-un-tipus-de-cancer-de-pulmo-incurable\/"},"modified":"2020-05-13T19:47:07","modified_gmt":"2020-05-13T17:47:07","slug":"demostren-lefectivitat-duna-nova-combinacio-de-farmacs-en-un-tipus-de-cancer-de-pulmo-incurable","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2016\/09\/demostren-lefectivitat-duna-nova-combinacio-de-farmacs-en-un-tipus-de-cancer-de-pulmo-incurable\/","title":{"rendered":"Demostren l\u2019efectivitat d\u2019una nova combinaci\u00f3 de f\u00e0rmacs en un tipus de c\u00e0ncer de pulm\u00f3 incurable"},"content":{"rendered":"

L\u2019estudi obre una prometedora via per a una patologia que a dia d\u2019avui no disposa de tractament Investigadors de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), liderats per la Dra. Montse Sanchez-Cespedes, han comprovat en estudis in vitro<\/em> i in vivo <\/em>l\u2019efectivitat d\u2019una nova combinaci\u00f3 de f\u00e0rmacs en el tractament d\u2019un subtipus de c\u00e0ncer de pulm\u00f3. L\u2019estudi, publicat<\/p>\n

la prestigiosa revista Oncogene<\/em>, obre una prometedora via per a una patologia que a dia d\u2019avui no disposa de tractament. <\/p>\n

\u201cPer primer cop hem trobat una s\u00e8rie de f\u00e0rmacs que, en combinaci\u00f3,<\/p>\n

aconsegueixen frenar el creixement tumoral d’aquest tipus de c\u00e0ncer\u201d explica la dra. Sanchez-Cespedes, autora principal de l\u2019estudi. <\/p>\n

En anteriors treballs, el grup de recerca havia demostrat, en l\u00ednees cel\u00b7lulars, que el tractament amb retinoides i corticoides inhibia el creixement i multiplicaci\u00f3 de les c\u00e8l\u00b7lules d\u2019un tipus de c\u00e0ncer de pulm\u00f3 associat amb una alteraci\u00f3 gen\u00e8tica, l\u2019amplificaci\u00f3 dels gens de la fam\u00edlia MYC . <\/p>\n

En l\u2019estudi actual, es demostra que quan els retinoides i corticoides es combinen amb azacitidina i SAHA, dos medicaments que actuen a nivell epigen\u00e8tic,<\/p>\n

es d\u00f3na un efecte sin\u00e8rgic i s’aconsegueix matar les c\u00e8l\u00b7lules amb aquesta alteraci\u00f3 gen\u00e8tica. <\/p>\n

El c\u00e0ncer de pulm\u00f3 \u00e9s el tipus de c\u00e0ncer m\u00e9s freq\u00fcent al m\u00f3n, i se sol dividir en dos grans tipus, c\u00e0ncer de pulm\u00f3 de c\u00e8l\u00b7lula petita i de c\u00e8l\u00b7lula no petita. \u201cL\u2019amplificaci\u00f3 de MYC es d\u00f3na en un 30% dels casos de c\u00e0ncer de pulm\u00f3<\/p>\n

de c\u00e8l\u00b7lula petita,\u201d comenta la dra. Sanchez-Cespedes, \u201cque a la vegada representen un 20% dels casos de c\u00e0ncer de pulm\u00f3. Es tracta d\u2019un nombre considerable de pacients per als quals avui en dia no es disposa de tractament\u201d.<\/p>\n

L’ estudi est\u00e0 fet en l\u00ednees cel\u00b7lulars i<\/p>\n

tamb\u00e9 amb models de ratol\u00ed, i per tant encara queda molt cam\u00ed per rec\u00f3rrer, per\u00f2 els resultats obtinguts per l\u2019equip de recerca de l\u2019IDIBELL obren una porta a l\u2019esperan\u00e7a. <\/p>\n

En el treball tamb\u00e9 s’han descrit els perfils gen\u00e8tics i epigen\u00e8tics de les c\u00e8l\u00b7lules tumorals tractades amb la nova combinaci\u00f3 de f\u00e0rmacs. \u201cAquestes c\u00e8l\u00b7lules tumorals, en general, estan poc diferenciades en comparaci\u00f3 amb les sanes, per\u00f2 quan administrem aquest tractament veiem un augment de marcadors de diferenciaci\u00f3 cel\u00b7lular; aix\u00f2 indica que el tractament promou canvis a nivell de transcripci\u00f3 gen\u00e8tica compatibles amb aquest increment\u201c apunta la investigadora de l\u2019IDIBELL.<\/p>\n","protected":false},"excerpt":{"rendered":"

L\u2019estudi obre una prometedora via per a una patologia que a dia d\u2019avui no disposa de tractament Investigadors de l’Institut d’Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), liderats per la Dra. Montse Sanchez-Cespedes, han comprovat en estudis in vitro i in vivo l\u2019efectivitat d\u2019una nova combinaci\u00f3 de f\u00e0rmacs en el tractament d\u2019un subtipus de c\u00e0ncer de pulm\u00f3. […]<\/p>\n","protected":false},"author":6,"featured_media":7930,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-05 07:09:21","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7929"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7929"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7929\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/7930"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7929"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7929"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7929"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}