<\/p>\ncodifica per una exonucleasa que s\u2019havia relacionat amb el manteniment de l\u2019estabilitat gen\u00f2mica, i amb determinats mecanismes tant de reparaci\u00f3 com de degradaci\u00f3 de l\u2019ADN. En estudis anteriors, el grup de recerca va observar que aquesta prote\u00efna s\u2019expressava espec\u00edficament en la pell. A m\u00e9s a m\u00e9s, l\u2019estudi del fenotip de ratolins deficients per aquesta prote\u00efna revela que la p\u00e8rdua de<\/p>\n
<\/span>TREX2<\/p>\n<\/em>provoca una major susceptibilitat a la carcinog\u00e8nesi de pell indu\u00efda per genot\u00f2xics com ara la radiaci\u00f3 ultraviolada (UV).<\/span> Per aprofundir en el paper de<\/p>\n<\/span>TREX2<\/p>\n<\/em>en l\u2019home\u00f2stasi i patog\u00e8nesi de la pell, els investigadors van voler con\u00e8ixer el paper d\u2019aquesta nucleasa en la psoriasi. Inicialment, van analitzar diferents bi\u00f2psies de pacients i de persones sense la malaltia. Despr\u00e9s, utilitzant diferents models de psoriasi en ratol\u00ed, van comparar l\u2019evoluci\u00f3 de la malaltia en ratolins normals i deficients per<\/p>\n<\/span>Trex2<\/p>\n<\/em>per inferir la funci\u00f3 d\u2019aquesta mol\u00e8cula. \u00abEls resultats mostren que<\/p>\n<\/span>Trex2<\/em>tindria un paper rellevant en la degradaci\u00f3 de l\u2019ADN en l\u2019epidermis psori\u00e0sica, en promoure la resposta inflamat\u00f2ria caracter\u00edstica d\u2019aquesta malaltia\u00bb, explica Concepci\u00f3 Soler, responsable de l\u2019estudi i professora del Departament de Patologia i Terap\u00e8utica Experimental de la Universitat de Barcelona.<\/span> L\u2019estudi mostra que la pell de pacients amb psoriasi experimenta un fort augment de l\u2019expressi\u00f3 de<\/p>\n<\/span>TREX2<\/em><\/p>\nque es concentra en el nucli cel\u00b7lular dels queratin\u00f2cits \u2014les c\u00e8l\u00b7lules m\u00e9s abundants de la pell\u2014, que proliferen, moren i es diferencien de manera aberrant. Per tant, els resultats suggereixen un paper important d\u2019aquest gen en el processament de l\u2019ADN. \u00abEn el nostre treball, posem de manifest el paper fonamental de<\/p>\n
<\/span>TREX2<\/em><\/p>\nen la degradaci\u00f3 de l\u2019ADN i la conseq\u00fcent mort cel\u00b7lular del queratin\u00f2cit, fet que influeix en la resposta immunit\u00e0ria a la pell. L\u2019alliberament de diversos senyals per part de les c\u00e8l\u00b7lules de la pell que s\u2019estan morint contribueix a generar i amplificar la resposta immunit\u00e0ria cr\u00f2nica i la hiperproliferaci\u00f3 i diferenciaci\u00f3 anormal de l\u2019epidermis\u00bb, explica el primer autor del treball, Joan Manils, membre del Departament esmentat i ara investigador postdoctoral a l\u2019Institut de Ci\u00e8ncies Biom\u00e8diques del Trinity College (Irlanda).<\/span> Els resultats situen<\/p>\n<\/span>TREX2<\/em><\/p>\ncom una potencial diana terap\u00e8utica per abordar aquesta malaltia amb una estrat\u00e8gia diferent i m\u00e9s focalitzada. \u00abLa majoria de tractaments actuals estan dirigits a bloquejar l\u2019acci\u00f3 del sistema immunitari, i si b\u00e9 donen bons resultats, s\u00f3n tractaments de car\u00e0cter cr\u00f2nic i comprometen la resposta immunit\u00e0ria del malalt\u00bb, explica Francisco Ciruela, coautor de l\u2019estudi, professor del Departament de Patologia i Terap\u00e8utica Experimental de la UB i cap del Grup de Recerca de Neurofarmacologia i Dolor a l\u2019IDIBELL.<\/span> El proper objectiu dels investigadors ser\u00e0 desxifrar el mecanisme d\u2019acci\u00f3 complet de<\/p>\n<\/span>TREX2<\/p>\n<\/em>en el desenvolupament i manteniment de la psoriasi per tal de dissenyar estrat\u00e8gies terap\u00e8utiques per tractar la malaltia.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"Un estudi publicat a la revista cient\u00edfica Journal of Investigative Dermatologyha identificat una diana terap\u00e8utica potencial per al tractament de la psoriasi, una malaltia inflamat\u00f2ria cr\u00f2nica de la pell que afecta fins a un 2 % de la poblaci\u00f3 i que encara no t\u00e9 cura. El treball demostra que el gen TREX2 t\u00e9 un paper […]<\/p>\n","protected":false},"author":6,"featured_media":7913,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1,513],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-11 18:09:46","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7912"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7912"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7912\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/7913"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7912"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7912"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}