Un innovador projecte sobre prevenci\u00f3 d’infeccions hospital\u00e0ries desenvolupat a l’Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) ha estat seleccionat per Caixaimpulse, el primer programa integral a Espanya per a la creaci\u00f3 d’empreses de biotecnologia, per rebre un suport financer de fins a 70.000 euros, aix\u00ed com un programa de formaci\u00f3 i assessorament d’experts. El projecte, liderat pel Dr. Rafael M\u00e1\u00f1ez, t\u00e9 com a objectiu establir un nou tractament per prevenir les infeccions nosocomials, que millorar\u00e0 la superviv\u00e8ncia del pacient juntament amb la reducci\u00f3 de les estades hospital\u00e0ries i els costos associats. <\/p>\n
S’estima que les infeccions hospital\u00e0ries o nocosomiales s\u00f3n una de les principals causes de mortalitat tant a Europa com als Estats Units, afectant al 10% dels pacients ingressats. Els bacteris gram-negatives representen la gran majoria de les infeccions, i s’associen amb condicions cl\u00edniques severes com ara s\u00e8psia i xoc s\u00e8ptic. <\/p>\n
L’amplificaci\u00f3 dependent d’anticossos (ADA) de la infecci\u00f3 es dona quan anticossos no neutralitzants preexistents s’uneixen a un patogen, facilitant la infecci\u00f3 en lloc d\u2019amortiguar-la. L’enfocament noved\u00f3s i \u00fanic desenvolupat pel grup de recerca del Dr. M\u00e1\u00f1ez pret\u00e9n augmentar la immunitat en aquests pacients mitjan\u00e7ant la desactivaci\u00f3 d’anticossos no neutralitzants amb glicoconjugats, potenciant aix\u00ed els anticossos neutralitzants. Aquest esgotament selectiu d’anticossos d’ADA per glicoconjugats millorar\u00e0 l’activitat bactericida en s\u00e8rum i previndr\u00e0 la mortalitat en infeccions Gram-negatives experimentals. <\/p>\n
L’\u00fas de glicoconjugats per estimular la immunitat \u00e9s un enfocament \u00fanic tant pel seu mecanisme d’acci\u00f3 com pel seu efecte, i podria convertir-se en una ter\u00e0pia molt efica\u00e7 per combatre infeccions per Gram-negatius. La possibilitat d’augmentar la immunitat simplement esgotant els anticossos no neutralitzants representa una innovaci\u00f3 radical com a enfocament terap\u00e8utic que tamb\u00e9 podria ser utilitzada en altres infeccions i c\u00e0ncer. <\/p>\n
Segons l’informe Innovation Union Scoreboard 2016 (IUS), Espanya compta amb infraestructures d’avantguarda, centres de recerca i professionals de primer nivell. No obstant aix\u00f2, ocupa el lloc 21 a la Uni\u00f3 Europea (UE) eninnovaci\u00f3n. <\/p>\n
Per ajudar a canviar aquesta realitat, Obra Social “la Caixa” i Caixa Capital Risc llan\u00e7ar CaixaImpulse, que utilitza la seva experi\u00e8ncia en els camps d’investigaci\u00f3, creaci\u00f3, desenvolupament i inversi\u00f3 en empreses en fase inicial per a un objectiu com\u00fa: la transfer\u00e8ncia de resultats de investigaci\u00f3 a la societat. <\/p>\n
Jordi Portabella, director de Recerca i Coneixement de la Fundaci\u00f3 Banc\u00e0ria “la Caixa”, i Carlos Trenchs, conseller delegat de Caixa Capital Risc, van presentar ahir totes les propostes innovadores seleccionades. Dels 73 projectes inicialment presentats, un comit\u00e8 d’experts ha elegit els 20 finalistes, 3 dels quals pertanyen al camp de les ci\u00e8ncies de la vida, mentre que 17 pertanyen a les ci\u00e8ncies m\u00e8diques i al sector sanitari.<\/p>\n","protected":false},"excerpt":{"rendered":"
Eliminaci\u00f3 d’anticossos amb glicoconjugats Valoraci\u00f3 i comercialitzaci\u00f3, desafiaments pendents<\/p>\n","protected":false},"author":6,"featured_media":10710,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-11 14:55:07","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7875"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7875"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7875\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10710"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7875"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7875"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7875"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}