{"id":7869,"date":"2016-12-21T00:00:00","date_gmt":"2016-12-20T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2016\/12\/21\/descriuen-les-causes-de-la-resistencia-de-les-cel%e2%80%a2lules-tumorals-a-la-terapia-amb-inhibidors-de-mtor\/"},"modified":"2020-05-13T19:47:00","modified_gmt":"2020-05-13T17:47:00","slug":"descriuen-les-causes-de-la-resistencia-de-les-cel%e2%80%a2lules-tumorals-a-la-terapia-amb-inhibidors-de-mtor","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2016\/12\/descriuen-les-causes-de-la-resistencia-de-les-cel%e2%80%a2lules-tumorals-a-la-terapia-amb-inhibidors-de-mtor\/","title":{"rendered":"Descriuen les causes de la resist\u00e8ncia de les c\u00e8l\u2022lules tumorals a la ter\u00e0pia amb inhibidors de mTOR"},"content":{"rendered":"<p>Investigadors del grup de recerca en c\u00e0ncer de mama del programa ProCURE ICO-IDIBELL han descrit per primer cop per qu\u00e8 els tumors s\u2019adapten i resisteixen a la ter\u00e0pia amb inhibidors de mTOR, un tractament emprat en estadis avan\u00e7ats d\u2019aquest tipus de c\u00e0ncer. Els resultats d\u2019aquest estudi internacional, publicats a la revista <em>Oncogene<\/em>, <\/p>\n<p>permeten establir nous pasos cap a una selecci\u00f3 m\u00e9s personalitzada de ter\u00e0pies en c\u00e0ncer. <\/p>\n<p> La via de senyalitzaci\u00f3 molecular de mTOR posseeix un paper central en el c\u00e0ncer. Tanmateix, la inhibici\u00f3 de mTOR en monoter\u00e0pia ha donat resultats molt limitats en<\/p>\n<p>la lluita contra diversos tipus tumorals. \u201cEn aquest estudi, demostrem que les c\u00e8l\u00b7lules tumorals s\u00f3n capaces d\u2019adaptar-se al tractament a trav\u00e9s d\u2019un canvi de fenotip que les fa m\u00e9s agressives i sost\u00e9 el seu potencial metast\u00e0tic\u201d, explica el Dr. Miquel \u00c0ngel Pujana, <\/p>\n<p>darrer autor de l\u2019estudi. <\/p>\n<p> Aix\u00ed, la ter\u00e0pia amb inhibidors indueix una reorganitzaci\u00f3 de la expressi\u00f3 g\u00e8nica que sustenta la via de senyalitzaci\u00f3 mTOR i permet a les c\u00e8l\u00b7lules cancer\u00edgenes colonitzar altres teixits i \u00f2rgans. \u201cPer tant, nom\u00e9s a trav\u00e9s de ter\u00e0pies combinades que impedeixin la reorganitzaci\u00f3 g\u00e8nica ser\u00e0 viable que els inhibidors de mTOR mostrin benefici de forma global\u201d, conclou l\u2019investigador.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigadors del grup de recerca en c\u00e0ncer de mama del programa ProCURE ICO-IDIBELL han descrit per primer cop per qu\u00e8 els tumors s\u2019adapten i resisteixen a la ter\u00e0pia amb inhibidors de mTOR, un tractament emprat en estadis avan\u00e7ats d\u2019aquest tipus de c\u00e0ncer. Els resultats d\u2019aquest estudi internacional, publicats a la revista Oncogene, permeten establir nous [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":10707,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-04 11:30:10","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7869"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7869"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7869\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10707"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7869"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7869"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7869"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}