{"id":7849,"date":"2017-02-08T00:00:00","date_gmt":"2017-02-07T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2017\/02\/08\/un-estudi-publicat-a-nature-reforca-la-contribucio-de-la-quinasa-s6k1-en-lobesitat-i-lenvelliment\/"},"modified":"2020-05-13T19:46:57","modified_gmt":"2020-05-13T17:46:57","slug":"un-estudi-publicat-a-nature-reforca-la-contribucio-de-la-quinasa-s6k1-en-lobesitat-i-lenvelliment","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2017\/02\/un-estudi-publicat-a-nature-reforca-la-contribucio-de-la-quinasa-s6k1-en-lobesitat-i-lenvelliment\/","title":{"rendered":"Un estudi publicat a Nature refor\u00e7a la contribuci\u00f3 de la quinasa S6K1 en l&#8217;obesitat i l\u2019envelliment"},"content":{"rendered":"<p><strong>La fosforilaci\u00f3 d\u2019EPRS condiciona les respostes metab\u00f2liques dependents de S6K1 relacionades amb l&#8217;obesitat i l&#8217;envelliment<\/strong> Els investigadors de l&#8217;Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) i de la Universitat de Barcelona (UB) George Thomas, cap del grup de recerca en Metabolisme i el C\u00e0ncer, i Sara Kozma, publiquen aquesta setmana a la revista <em>Nature<\/em> un article sobre el paper de la quinasa S6K1 en el canvi de funci\u00f3 de la glutamil-prolil-tRNA sintetasa (EPRS) d\u2019inhibidora de la traducci\u00f3 a transportadora d&#8217;\u00e0cids grassos. L&#8217;estudi es va dur a terme en col\u00b7laboraci\u00f3 amb investigadors de la Cleveland Clinic i la Universitat d&#8217;Illinois, i podria conduir potencialment al desenvolupament de biomarcadors i ter\u00e0pies dirigides contra l&#8217;obesitat i l&#8217;envelliment. <\/p>\n<p> Estudis anteriors dels doctors Thomas i Kozma de l\u2019IDIBELL-UB ja havien demostrat que S6K1 exerceix un paper cr\u00edtic en l&#8217;expansi\u00f3 dels teixits grassos mitjan\u00e7ant la regulaci\u00f3 transcripcional de la diferenciaci\u00f3 de les c\u00e8l\u00b7lules mare mesenquimals (MSC) en adip\u00f2cits (c\u00e8l\u00b7lules de greix). &#8220;Mentrestant&#8221;, explica el Dr. Thomas, &#8220;Paul Fox es va posar en contacte amb nosaltres proposant una possible connexi\u00f3 entre S6K1 i l&#8217;enzim EPRS. Junts vam descobrir que la fosforilaci\u00f3 <\/p>\n<p>de S6K1 \u00e9s necess\u00e0ria per alliberar EPRS del seu paper habitual en la s\u00edntesi de prote\u00efnes i formar el complex inhibidor de la traducci\u00f3 d&#8217;interfer\u00f3 \u0263 (GAIT), que bloqueja la traducci\u00f3 de gens regulats per l\u2019interfer\u00f3&#8221;. <\/p>\n<p> &#8220;Aquest canvi de funci\u00f3 es determinant, ja que paral\u00b7lelament vam observar que EPRS interv\u00e9 en la localitzaci\u00f3 de la prote\u00efna de transport d&#8217;\u00e0cids grassos 1 (FATP1) dins la membrana, estimulant la captaci\u00f3 d&#8217;\u00e0cids grassos de cadena llarga&#8221;, afegeix la Dra. Kozma. &#8220;Aix\u00f2 va confirmar el doble paper de S6K1 en la seva contribuci\u00f3 a l&#8217;adipositat i l&#8217;envelliment. De fet, els ratolins amb EPRS sense fosforilar presenten les mateixes caracter\u00edstiques f\u00edsiques (fenotip) que els ratolins deficients en S6K1: pes corporal baix, massa de teixit adip\u00f3s redu\u00efda i augment de l&#8217;esperan\u00e7a de vida. Aquests resultats reforcen el concepte que S6K1 pot servir com a biomarcador de l&#8217;obesitat o com a diana de f\u00e0rmacs contra l&#8217;obesitat&#8221;. <\/p>\n<p> La Dra. Kozma col\u00b7labora actualment amb el grup de recerca CIBERobn del Dr. Jos\u00e9 Manuel Fern\u00e1ndez-Real (Hospital Josep Trueta \u2013 IDIBGI) en un projecte finan\u00e7at per La Marat\u00f3 de TV3 per obtenir mostres de teixit gras hum\u00e0 que permetin validar aquests resultats en \u00e9ssers humans i desenvolupar nous biomarcadors d&#8217;expansi\u00f3 del teixit adip\u00f3s.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La fosforilaci\u00f3 d\u2019EPRS condiciona les respostes metab\u00f2liques dependents de S6K1 relacionades amb l&#8217;obesitat i l&#8217;envelliment<\/p>\n","protected":false},"author":6,"featured_media":10697,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-04 21:29:57","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7849"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7849"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7849\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10697"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7849"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7849"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7849"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}