{"id":7829,"date":"2017-03-06T00:00:00","date_gmt":"2017-03-05T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2017\/03\/06\/lestil-de-vida-determina-mes-el-risc-de-cancer-de-colon-i-recte-que-la-genetica\/"},"modified":"2020-05-13T19:46:53","modified_gmt":"2020-05-13T17:46:53","slug":"lestil-de-vida-determina-mes-el-risc-de-cancer-de-colon-i-recte-que-la-genetica","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2017\/03\/lestil-de-vida-determina-mes-el-risc-de-cancer-de-colon-i-recte-que-la-genetica\/","title":{"rendered":"L\u2019estil de vida determina m\u00e9s el risc de c\u00e0ncer de c\u00f2lon i recte que la gen\u00e8tica"},"content":{"rendered":"<p>Investigadors del grup de recerca en C\u00e0ncer Colorectal de l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), liderat pel Dr. V\u00edctor Moreno, i vinculat a l\u2019Institut Catal\u00e0 d\u2019Oncologia (ICO), la Universitat de Barcelona (UB) i el CIBER d\u2019Epidemiologia i Salut P\u00fablica (CIBEResp), han desenvolupat el primer model de predicci\u00f3 del risc de c\u00e0ncer de c\u00f2lon i recte basat en dades a nivell espanyol que combina informaci\u00f3 gen\u00e8tica amb estils de vida. El seu treball, publicat per la revista <em>Scientific Reports<\/em>, destaca la import\u00e0ncia de millorar l\u2019estil de vida per disminuir el risc de c\u00e0ncer de c\u00f2lon i proposa utilitzar informaci\u00f3 gen\u00e8tica, combinada amb l\u2019estil de vida, per subdividir la poblaci\u00f3 en diferents grups segons el risc de c\u00e0ncer de c\u00f2lon i, aix\u00ed, afinar el m\u00e8tode de detecci\u00f3 preco\u00e7 (cribratge) actual. <\/p>\n<p> \u201cUn model de risc \u00e9s un instrument matem\u00e0tic que ens permet fer una predicci\u00f3 de qui t\u00e9 m\u00e9s possibilitats de patir una determinada malaltia, en aquest cas c\u00e0ncer de c\u00f2lon\u201d, explica el Dr. Moreno, cap del Programa de Prevenci\u00f3 i Control del C\u00e0ncer de l&#8217;ICO. Per desenvolupar-lo, els investigadors han utilitzat les dades provinents de l\u2019estudi multic\u00e8ntric espanyol \u201cMCC-Spain\u201d (<a href=\"http:\/\/www.mccspain.org\/\">http:\/\/www.mccspain.org<\/a>), realitzat de forma col\u00b7lectiva per investigadors pertanyents al CIBEResp, i que va comptar amb 10.106 participants. A tots ells se\u2019ls va fer una entrevista per analitzar els factors de risc coneguts (dieta, exercici f\u00edsic, \u00edndex de massa corporal, alcohol, antecedents familiars de c\u00e0ncer, entre d\u2019altres) i, a un subgrup de 1.336 casos de c\u00e0ncer colorectal i a 2.744 controls, se\u2019ls van fer una an\u00e0lisi de sang per detectar la predisposici\u00f3 gen\u00e8tica de desenvolupar un c\u00e0ncer de c\u00f2lon i recte. <\/p>\n<p> Amb tota aquesta informaci\u00f3, l\u2019equip de recerca ha concl\u00f2s que l\u2019estil de vida determina m\u00e9s el risc de c\u00e0ncer que la gen\u00e8tica. Han calculat que si es canvia un estil de vida de risc (per exemple, si s\u2019obt\u00e9 un pes saludable), aix\u00f2 pot compensar el tenir 4 punts (al\u00b7lels de risc) de predisposici\u00f3 gen\u00e8tica. \u201cAix\u00f2 \u00e9s important tenint en compte que l\u2019estil de vida, a difer\u00e8ncia dels trets gen\u00e8tics, \u00e9s quelcom modificable, mentre que la susceptibilitat gen\u00e8tica l\u2019heretem dels nostres pares\u201d, comenta la Dra. Gemma Ib\u00e1\u00f1ez, digest\u00f2loga i primera autora de l\u2019estudi; \u201cde fet, els \u00edtems que hem identificat com a marcadors de risc correlacionen amb les recomanacions establertes pel <a href=\"sites\/default\/files\/importn\/Noticies\/2015\/1T\/codicancer_cat.pdf\">Codi Europeu contra el c\u00e0ncer<\/a>, publicat ara fa un any, per reduir el risc de patir c\u00e0ncer\u201d. <\/p>\n<p> \u201cAvui en dia, el cribratge en c\u00e0ncer de c\u00f2lon, en pacients que no tenen antecedents familiars, es basa \u00fanicament en l\u2019edat. Si inclogu\u00e9ssim informaci\u00f3 referent als estils de vida i la gen\u00e8tica, podr\u00edem classificar la poblaci\u00f3 en grups de major o menor risc, cosa que ens permetria fer un seguiment m\u00e9s personalitzat\u201d, comenta el Dr. Moreno, que tamb\u00e9 \u00e9s catedr\u00e0tic de la Facultat de Medicina i Ci\u00e8ncies de la Salut de la UB. <\/p>\n<p> Actualment, l\u2019equip de recerca que ha participat en l\u2019estudi est\u00e0 conduint un nou estudi anomenat COLSCREEN: \u201cPersonalitzaci\u00f3 del risc de c\u00e0ncer colorectal\u201d per, entre d\u2019altres coses, determinar quina \u00e9s la percepci\u00f3 social sobre el cribratge gen\u00e8tic. \u201cNo hi ha estudis que determinin qu\u00e8 pensen els pacients sobre les proves gen\u00e8tiques i si voldran ser informats de les seves probabilitats de tenir certes malalties i creiem que \u00e9s molt rellevant\u201d, comenta la Dra. Ib\u00e1\u00f1ez. Paral\u00b7lelament, amb aquest mateix nou estudi els investigadors volen veure la utilitat del sistema de puntuaci\u00f3 de risc de patir c\u00e0ncer de c\u00f2lon aplicant-lo de forma prospectiva en la poblaci\u00f3 del Baix Llobregat. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Es presenta el primer model de predicci\u00f3 de risc basat en dades de la poblaci\u00f3 espanyola<\/p>\n","protected":false},"author":6,"featured_media":10685,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7829","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-11-30 02:01:03","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7829","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7829"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7829\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10685"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7829"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7829"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7829"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}