{"id":7807,"date":"2017-03-28T00:00:00","date_gmt":"2017-03-27T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2017\/03\/28\/el-consorci-europeu-it-liver-revela-noves-funcions-del-tgf-beta-en-cancer-de-fetge\/"},"modified":"2020-05-13T19:46:52","modified_gmt":"2020-05-13T17:46:52","slug":"el-consorci-europeu-it-liver-revela-noves-funcions-del-tgf-beta-en-cancer-de-fetge","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2017\/03\/el-consorci-europeu-it-liver-revela-noves-funcions-del-tgf-beta-en-cancer-de-fetge\/","title":{"rendered":"El consorci europeu IT-LIVER revela noves funcions del TGF-beta en c\u00e0ncer de fetge"},"content":{"rendered":"<p>Resultats recents del grup de recerca en TGF-beta i c\u00e0ncer de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), en el context d&#8217;IT-Liver, una acci\u00f3 europea col\u00b7laborativa entre diversos grups de recerca i liderada per la Dra. Isabel Fabregat, han condu\u00eft a entendre millor el paper de la citoquina TGF-beta en c\u00e0ncer de fetge. El seu treball, publicat per la revista <em>Cancer Letters<\/em>, mostra com el TGF-beta \u00e9s capa\u00e7 de modular no nom\u00e9s la capacitat migrat\u00f2ria de la c\u00e8l\u00b7lula de carcinoma hepatocel\u00b7lular sin\u00f3 tamb\u00e9 la seva capacitat com a c\u00e8l\u00b7lula iniciadora de tumors. <\/p>\n<p> El TFG-beta juga un paper dual en c\u00e0ncer:a l&#8217;inici de la patologia, actua com a supressor de tumors, per\u00f2 en estats avan\u00e7ats en pot promoure la generaci\u00f3. &#8220;El que fins ara s&#8217;havia estudiat amb m\u00e9s detall \u00e9s la relaci\u00f3 entre el potencial tumorig\u00e8nic del TGF-beta i la seva capacitat d&#8217;induir un proc\u00e9s conegut com a transici\u00f3 epiteli-mes\u00e8nquima, que afavoreix la migraci\u00f3 de les c\u00e8l\u00b7lules canceroses. El present treball tamb\u00e9 posa de manifest que durant aquest proc\u00e9s el TGF-beta tamb\u00e9 podria modular la capacitat de la c\u00e8l\u00b7lula tumoral de comportar-se com a iniciadora de tumors&#8221;, explica la Dra. Isabel Fabregat, professora associada de la Universitat de Barcelona i darrera autora del treball. <\/p>\n<p>&#8220;El tumor necessita que aquelles c\u00e8l\u00b7lules que passen al torrent circulatori o limf\u00e0tic tinguin capacitat migrat\u00f2ria per possibilitar el seu trasllat en fases d&#8217;invasi\u00f3, per\u00f2 alhora tamb\u00e9 cal que aquestes c\u00e8l\u00b7lules tinguin capacitat d&#8217;iniciaci\u00f3 tumoral per tal de poder metastatitzar i expandir-se un cop han arribat al seu dest\u00ed&#8221;, comenta la investigadora de l&#8217;IDIBELL. Les c\u00e8l\u00b7lules de tipus epitelial poden actuar com a c\u00e8l\u00b7lules iniciadores de tumors, per\u00f2 no tenen capacitat de migraci\u00f3; en canvi, les c\u00e8l\u00b7lules mesenquimals tenen alta capacitat migrat\u00f2ria. <\/p>\n<p>&#8220;Curiosament, l&#8217;estudi demostra que les c\u00e8l\u00b7lules amb major capacitat com iniciadores de tumors no s\u00f3n les de tipus mesenquimal, sin\u00f3 les que expressen un fenotip intermedi epiteli-mes\u00e8nquima, que combinaria la capacitat de c\u00e8l\u00b7lula iniciadora amb un major potencial migratori; aquesta \u00e9s la gran novetat que aporta el nostre treball&#8221;, afegeix Fabregat. <\/p>\n<p> El consorci IT-Liver (Inhibint TGF-\u03b2 en malalties hep\u00e0tiques), que ha possibilitat l&#8217;estudi, \u00e9s una xarxa de formaci\u00f3 inicial europea Marie Curie (ITN) liderada des de l&#8217;IDIBELL. Durant els \u00faltims 4 anys, IT-Liver ha creat un programa combinat d&#8217;investigaci\u00f3 i capacitaci\u00f3 tant per a investigadors en fase primerenca com per a investigadors experimentats, amb l&#8217;objectiu de con\u00e8ixer millor els mecanismes moleculars de la malaltia hep\u00e0tica en qu\u00e8 participa el TGF-beta, a m\u00e9s de proporcionar una comprensi\u00f3 profunda de la biologia molecular de les c\u00e8l\u00b7lules del fetge i millorar tamb\u00e9 les compet\u00e8ncies en activitats de transfer\u00e8ncia de tecnologia (per exemple, gesti\u00f3 de propietat intel\u00b7lectual, valoritzaci\u00f3 i emprenedoria).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Resultats recents del grup de recerca en TGF-beta i c\u00e0ncer de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), en el context d&#8217;IT-Liver, una acci\u00f3 europea col\u00b7laborativa entre diversos grups de recerca i liderada per la Dra. Isabel Fabregat, han condu\u00eft a entendre millor el paper de la citoquina TGF-beta en c\u00e0ncer de fetge. El seu treball, [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":10670,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-10 03:27:51","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7807"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7807"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7807\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10670"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7807"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7807"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7807"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}