{"id":7805,"date":"2017-03-29T00:00:00","date_gmt":"2017-03-28T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2017\/03\/29\/descoberta-una-lesio-epigenetica-causant-de-la-leucemia-aguda-de-tipus-t\/"},"modified":"2020-05-13T19:46:52","modified_gmt":"2020-05-13T17:46:52","slug":"descoberta-una-lesio-epigenetica-causant-de-la-leucemia-aguda-de-tipus-t","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2017\/03\/descoberta-una-lesio-epigenetica-causant-de-la-leucemia-aguda-de-tipus-t\/","title":{"rendered":"Descoberta una lesi\u00f3 epigen\u00e8tica causant de la leuc\u00e8mia aguda de tipus T"},"content":{"rendered":"<p>Investigadors del Programa d&#8217;Epigen\u00e8tica i Biologia del C\u00e0ncer (PEBC) dirigit per Dr. Manel Esteller a l&#8217;Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), han descobert com una lesi\u00f3 epigen\u00e8tica pot generar una leuc\u00e8mia limfobl\u00e0stica aguda de limf\u00f2cits T. L&#8217;article, publicat a la revista <em>Leukemia<\/em>, l\u00edder en el camp de la hematologia, relaciona la lesi\u00f3 amb l&#8217;activaci\u00f3 d&#8217;un potent oncogen capa\u00e7 de malignitzar aquest tipus de c\u00e8l\u00b7lules del sistema immunitari. <\/p>\n<p> Cada dos minuts una persona al m\u00f3n \u00e9s diagnosticada d&#8217;un c\u00e0ncer de les c\u00e8l\u00b7lules de la sang, ja sigui una leuc\u00e8mia, un limfoma o un mieloma, constituint l\u201911% dels tumors detectats cada any. La leuc\u00e8mia limfobl\u00e0stica aguda de limf\u00f2cits T (T-ALL) d\u00f3na lloc a alteracions en el desenvolupament normal dels limf\u00f2cits T, que s\u00f3n les c\u00e8l\u00b7lules responsables de la defensa contra les infeccions. Aquest tipus de leuc\u00e8mia, que pot apar\u00e8ixer tant en nens com en adults, es caracteritza pel seu comportament agressiu. Hi ha determinades alteracions gen\u00e8tiques responsables de fins a una tercera part dels casos, per\u00f2 encara es desconeixen els canvis moleculars implicats en la resta. <\/p>\n<p> &#8220;<em>Hem descobert que en un 60% de leuc\u00e8mies agudes de tipus T, els limf\u00f2cits T presenten p\u00e8rdua d&#8217;activitat d&#8217;un gen anomenat NUDT16, que t\u00e9 com a funci\u00f3 normal degradar altres gens potencialment perillosos. La manca de supervisi\u00f3 de NUDT16 en aquests limf\u00f2cits T provoca que un gen \u00e0mpliament reconegut com a causant de c\u00e0ncer, anomenat C-MYC, actu\u00ef lliurement i transformi a aquestes c\u00e8l\u00b7lules sanes en canceroses<\/em>&#8220;- explica el Dr. Esteller, investigador ICREA i Professor de Gen\u00e8tica de la Universitat de Barcelona. <\/p>\n<p>&#8220;\u00c9s interessant recon\u00e8ixer que com el gen NUDT16 no est\u00e0 gen\u00e8ticament malm\u00e8s, i per tant es podria reactivar amb f\u00e0rmacs epigen\u00e8tics ja usats en altres tipus de leuc\u00e8mies i limfomes. A m\u00e9s a m\u00e9s, valdria la pena provar si aquestes leuc\u00e8mies, en ser tan dependents de l&#8217;oncogen C-MYC, serien tamb\u00e9 m\u00e9s sensibles a f\u00e0rmacs que tinguessin com a diana aquesta prote\u00efna&#8221;, afegeix l\u2019investigador de l\u2019IDIBELL. <\/p>\n<p> La investigaci\u00f3 s&#8217;ha realitzat amb la col\u00b7laboraci\u00f3 cl\u00ednica dels Serveis d&#8217;Hematologia de l&#8217;Hospital de la Santa Creu i Sant Pau a Barcelona i de l&#8217;Hospital Germans Trias i Pujol a Badalona, \u200b\u200baix\u00ed com de l&#8217;Institut de Recerca contra la Leuc\u00e8mia Josep Carreras.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigadors del Programa d&#8217;Epigen\u00e8tica i Biologia del C\u00e0ncer (PEBC) dirigit per Dr. Manel Esteller a l&#8217;Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), han descobert com una lesi\u00f3 epigen\u00e8tica pot generar una leuc\u00e8mia limfobl\u00e0stica aguda de limf\u00f2cits T. L&#8217;article, publicat a la revista Leukemia, l\u00edder en el camp de la hematologia, relaciona la lesi\u00f3 amb l&#8217;activaci\u00f3 d&#8217;un [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":10669,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-09 14:15:53","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7805"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7805"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7805\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10669"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7805"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7805"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7805"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}