{"id":7772,"date":"2017-07-07T00:00:00","date_gmt":"2017-07-06T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2017\/07\/07\/noves-estrategies-epigenomiques-en-la-gestio-clinica-del-cancer-dorigen-desconegut\/"},"modified":"2020-05-13T19:46:45","modified_gmt":"2020-05-13T17:46:45","slug":"noves-estrategies-epigenomiques-en-la-gestio-clinica-del-cancer-dorigen-desconegut","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2017\/07\/noves-estrategies-epigenomiques-en-la-gestio-clinica-del-cancer-dorigen-desconegut\/","title":{"rendered":"Noves estrat\u00e8gies epigen\u00f2miques en la gesti\u00f3 cl\u00ednica del c\u00e0ncer d&#8217;origen desconegut"},"content":{"rendered":"<p>La creaci\u00f3 del test epigen\u00e8tic EPICUP\u00ae ha perm\u00e8s en el darrer any descobrir quin tipus de tumor primari ha produ\u00eft la met\u00e0stasi en pacients de C\u00e0ncer d&#8217;Origen Desconegut (COD, o en les seves sigles en angl\u00e8s, CUP &#8211; <em>Cancer of Unknown Primary<\/em>). Avui, un article publicat a <em>Nature Reviews Clinical Oncology<\/em> pel Dr. Manel Esteller, coordinador del Programa d&#8217;Epigen\u00e8tica i Biologia del C\u00e0ncer de l&#8217;Institut d&#8217;Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), Investigador ICREA i Professor de Gen\u00e8tica de la Universitat de Barcelona, \u200b\u200bexplica com s&#8217;est\u00e0 implantant aquesta prova en la pr\u00e0ctica cl\u00ednica i els nous aven\u00e7os que es poden derivar-se\u2019n. <\/p>\n<p> &#8220;Nom\u00e9s en un 30% de casos de met\u00e0stasi d&#8217;origen desconegut dels m\u00e8todes tradicionals permeten detectar el tumor primari on aquesta s&#8217;ha originat. Alguns m\u00e8todes moleculars permeten augmentar aquest percentatge, per\u00f2 solen ser cars i fan servir la mol\u00e8cula d&#8217;ARN (\u00e0cid ribonucleic) que \u00e9s molt fr\u00e0gil i sol trencar-se amb facilitat en les mostres disponibles en els serveis d&#8217;anatomia patol\u00f2gica dels hospitals\u201d, comenta el Dr. Manel Esteller. <\/p>\n<p>&#8220;El test EPICUP\u00ae, en canvi, es basa en la mol\u00e8cula d&#8217;ADN, que \u00e9s molt estable, i permet l&#8217;enviament des de l&#8217;hospital on es troba el pacient fins al laboratori d&#8217;an\u00e0lisi de forma senzilla. Els resultats es poden obtenir en una semana\u201d, afegeix l&#8217;investigador. <\/p>\n<p> El C\u00e0ncer d&#8217;Origen Desconegut (COD) representa el 10% dels tumors humans en qu\u00e8 es detecta la met\u00e0stasi, per\u00f2 no \u00e9s possible localitzar el tumor primari malgrat es duguin a terme diverses proves explorat\u00f2ries. Com que es desconeix de quin tipus de tumor es tracta, la superviv\u00e8ncia d&#8217;aquests pacients \u00e9s molt curta; la implementaci\u00f3 del test EPICUP\u00ae permetr\u00e0 desenvolupar tractaments m\u00e9s espec\u00edfics en el futur, d&#8217;acord amb els resultats exposats a <em>Nature Reviews Clinical Oncology<\/em>: &#8220;Fan falta assajos prospectius per determinar com aquests pacients amb CUP, ara correctament diagnosticats, es poden beneficiar de tractaments m\u00e9s espec\u00edfics i menys agressius per a la seva malaltia&#8221;, conclou el Dr. Esteller.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La creaci\u00f3 del test epigen\u00e8tic EPICUP\u00ae ha perm\u00e8s en el darrer any descobrir quin tipus de tumor primari ha produ\u00eft la met\u00e0stasi en pacients de C\u00e0ncer d&#8217;Origen Desconegut (COD, o en les seves sigles en angl\u00e8s, CUP &#8211; Cancer of Unknown Primary). Avui, un article publicat a Nature Reviews Clinical Oncology pel Dr. Manel Esteller, [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":10651,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-10 06:16:30","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7772"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7772"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7772\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10651"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7772"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7772"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7772"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}