Investigadors del Grup de Cromatina i Malaltia de l’Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL) a Barcelona han identificat un esdeveniment epigen\u00e8tic distintiu en les c\u00e8l\u00b7lules immunit\u00e0ries que s\u2019han diferenciat en el microambient tumoral que les fa tolerants a les c\u00e8l\u00b7lules canceroses. <\/p>\n
En els darrers anys, s’han trobat cada vegada m\u00e9s evid\u00e8ncies que els factors inflamatoris alliberats al microambient tumoral s\u00f3n capa\u00e7os de redirigir la diferenciaci\u00f3 de c\u00e8l\u00b7lules dendr\u00edtiques promotores d’immunitat a c\u00e8l\u00b7lules supressores derivades de mieloides, el que disminueix la capacitat del sistema immunitari del pacient de c\u00e0ncer per lluitar contra les c\u00e8l\u00b7lules canceroses. Una s\u00e8rie d’estudis han identificat factors, com ara la prostaglandina E2, que tenen la capacitat de subvertir la immunitat dels pacients amb c\u00e0ncer. <\/p>\n
En aquest estudi, publicat a Cell Reports<\/em> i liderat pel Dr. Esteban Ballestar (IDIBELL), la comparaci\u00f3 entre els perfils epigen\u00e8tics de les c\u00e8l\u00b7lules dendr\u00edtiques i les c\u00e8l\u00b7lules supressores derivades de mieloides ha perm\u00e8s identificar l’exist\u00e8ncia d’alteracions epigen\u00e8tiques espec\u00edfiques que poden associar-se amb el desenvolupament de c\u00e8l\u00b7lules supressores derivades de mieloides com a resultat de l’exposici\u00f3 a la prostaglandina E2. <\/p>\n L’equip ha pogut demostrar que aquestes alteracions epigen\u00e8tiques estan associades amb l’augment dels nivells d’un enzim, la ADN metiltransferasa 3A (DNMT3A), responsable de l’adquisici\u00f3 de les propietats supressores d’aquestes c\u00e8l\u00b7lules que es desenvolupen en el microambient tumoral. La inhibici\u00f3 de DNMT3A va donar com a resultat la deleci\u00f3 de les propietats supressores d’aquestes c\u00e8l\u00b7lules. <\/p>\n Una de les troballes m\u00e9s rellevants d’aquest estudi \u00e9s que les caracter\u00edstiques epigen\u00e8tiques observades d’aquestes c\u00e8l\u00b7lules tamb\u00e9 s\u00f3n presents en c\u00e8l\u00b7lules supressores derivades de mieloides a\u00efllades en pacients amb carcinoma ov\u00e0ric. Donat l’inter\u00e8s existent en el desenvolupament de f\u00e0rmacs contra les metiltransferases de l’ADN, els resultats d’aquest equip obren potencials oportunitats terap\u00e8utiques que requeriran exploraci\u00f3 addicional. <\/p>\n Aquest estudi s’ha completat amb la participaci\u00f3 d’investigadors i cl\u00ednics de la Universitat de Pittsburg, de la Universitat de Calif\u00f2rnia a Irvine i de la Fundaci\u00f3 MD Anderson International a Madrid. Rodr\u00edguez-Ubreva, J., Catal\u00e0-Moll, F., Obermajer, N., \u00c1lvarez-Errico, D., Ramirez, R.N., Company, C., Vento-Tormo, R., Moreno-Bueno, G., Edwards, R.P., Mortazavi, A., Kalinski, P., and Ballestar, E. (2017) Prostaglandin E2 leads to the acquisition of DNMT3A-dependent tolerogenic functions in human myeloid-derived suppressor cells. Cell Reports.<\/p>\n","protected":false},"excerpt":{"rendered":" El microambient tumoral subverteix la funci\u00f3 de les c\u00e8l\u00b7lules immunit\u00e0ries Un regulador clau de les c\u00e8l\u00b7lules supressores derivades de mieloides i la possibilitat de revertir els seus efectes sobre la funci\u00f3 immunol\u00f2gica Refer\u00e8ncia de l\u2019article<\/p>\n","protected":false},"author":6,"featured_media":10640,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7752","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-12-30 06:36:12","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7752","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7752"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7752\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10640"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7752"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7752"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7752"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}