{"id":7707,"date":"2018-01-29T00:00:00","date_gmt":"2018-01-28T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/blog\/2018\/01\/29\/la-catedra-extraordinaria-del-dolor-premia-francisco-ciruela-pel-disseny-del-primer-fotofarmac-amb-accio-analgesica\/"},"modified":"2020-05-13T19:46:35","modified_gmt":"2020-05-13T17:46:35","slug":"la-catedra-extraordinaria-del-dolor-premia-francisco-ciruela-pel-disseny-del-primer-fotofarmac-amb-accio-analgesica","status":"publish","type":"post","link":"https:\/\/idibell.cat\/2018\/01\/la-catedra-extraordinaria-del-dolor-premia-francisco-ciruela-pel-disseny-del-primer-fotofarmac-amb-accio-analgesica\/","title":{"rendered":"La C\u00e0tedra Extraordin\u00e0ria del Dolor premia Francisco Ciruela pel disseny del primer fotof\u00e0rmac amb acci\u00f3 analg\u00e8sica"},"content":{"rendered":"<p>El professor Francisco Ciruela, de la\u00a0<a href=\"http:\/\/www.ub.edu\/medicina\/\" target=\"_self\" rel=\"noopener noreferrer\">Facultat de Medicina i Ci\u00e8ncies de la Salut<\/a>\u00a0de la Universitat de Barcelona,\u00a0<a href=\"http:\/\/www.neurociencies.ub.edu\/\" target=\"_self\" rel=\"noopener noreferrer\">l\u2019Institut de Neuroci\u00e8ncies\u00a0<\/a>de la UB i l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (<a href=\"http:\/\/www.idibell.cat\/\" target=\"_self\" rel=\"noopener noreferrer\">IDIBELL),<\/a>\u00a0ha estat distingit amb el Premi d\u2019Investigaci\u00f3 Precl\u00ednica de la C\u00e0tedra Extraordin\u00e0ria del Dolor de la Universitat de Salamanca-Fundaci\u00f3 Gr\u00fcnenthal. Aquest guard\u00f3 premia una recerca amb models animals, publicada a la revista\u00a0<a href=\"https:\/\/elifesciences.org\/content\/6\/e23545\" target=\"_self\" rel=\"noopener noreferrer\"><em>eLife,<\/em><\/a>\u00a0que va culminar amb el disseny del\u00a0<a href=\"http:\/\/www.ub.edu\/web\/ub\/ca\/menu_eines\/noticies\/2017\/04\/014.html\" target=\"_self\" rel=\"noopener noreferrer\">primer fotof\u00e0rmac\u00a0<\/a>\u2014el JF-NP-26, activat per la llum\u2014, amb potencials aplicacions terap\u00e8utiques per tractar el dolor.<\/p>\n<p>El treball premiat \u2014codirigit pels experts Francisco Ciruela i Amadeu Llebaria, del Grup de Qu\u00edmica M\u00e8dica i S\u00edntesi (MCS) de l\u2019Institut de Qu\u00edmica Avan\u00e7ada de Catalunya\u00a0<a href=\"http:\/\/www.iqac.csic.es\/index.php?lang=es\" target=\"_self\" rel=\"noopener noreferrer\">(IQAC-CSIC)<\/a>\u2014 \u00e9s un aven\u00e7 destacat en el camp de l\u2019optofarmacologia, una disciplina emergent que es basa en l\u2019\u00fas de la llum per controlar l\u2019activitat dels medicaments.\u00a0<\/p>\n<p>\u00abEn l\u2019\u00e0mbit cl\u00ednic no existeix cap precedent de l\u2019\u00fas de l\u2019optofarmacologia per millorar el tractament del dolor ni de cap patologia relacionada amb el sistema nervi\u00f3s. En el terreny precl\u00ednic, \u00e9s a dir, amb models animals, aquest \u00e9s el\u00a0 primer fotof\u00e0rmac dissenyat per al tractament del dolor\u00a0<em>in vivo<\/em>\u00bb, detalla el professor Francisco Ciruela.<\/p>\n<p>El fotof\u00e0rmac JF-NP-26 \u00e9s el que s\u2019anomena un\u00a0<em>photocaged<\/em>\u00a0\u2014una mol\u00e8cula emmascarada qu\u00edmicament i inactiva, que s\u2019activa mitjan\u00e7ant la llum\u2014, que no mostra efectes t\u00f2xics ni indesitjables en animals, ni tan sols en dosis elevades en estudis de curta durada. Quan s\u2019administra a un animal, no t\u00e9 cap efecte farmacol\u00f2gic fins que el teixit diana \u00e9s irradiat amb llum de l\u2019espectre visible (amb una longitud d\u2019ona de 405 nm).\u00a0<\/p>\n<p>En la categoria d\u2019Investigaci\u00f3 Cl\u00ednica, tamb\u00e9 ha estat distingit un treball dirigit pel professor Enrique Lluch, de la Universitat de Val\u00e8ncia, per generar mapes de freq\u00fc\u00e8ncia del dolor en pacients afectats per artrosi al genoll.\u00a0<\/p>\n<p>Els premis de la C\u00e0tedra Extraordin\u00e0ria del Dolor s\u00f3n un reconeixement als projectes m\u00e9s innovadors sobre el dolor \u2014des de la vessant epidemiol\u00f2gica, experimental, farmacol\u00f2gica i cl\u00ednica\u2014, i van ser lliurats en un acte acad\u00e8mic celebrat a la Universitat de Salamanca el passat 27 de gener.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>El professor Francisco Ciruela, de la\u00a0Facultat de Medicina i Ci\u00e8ncies de la Salut\u00a0de la Universitat de Barcelona,\u00a0l\u2019Institut de Neuroci\u00e8ncies\u00a0de la UB i l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL),\u00a0ha estat distingit amb el Premi d\u2019Investigaci\u00f3 Precl\u00ednica de la C\u00e0tedra Extraordin\u00e0ria del Dolor de la Universitat de Salamanca-Fundaci\u00f3 Gr\u00fcnenthal. Aquest guard\u00f3 premia una recerca amb models animals, [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":10617,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[340,344],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-05 11:58:26","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7707"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7707"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7707\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10617"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7707"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7707"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7707"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}