El grup de la Dra\u00a0Conxi L\u00e1zaro, investigadora principal del grup de recerca en C\u00e0ncer hereditari del programa Oncobell (IDIBELL) i cap de la Unitat de diagn\u00f2stic molecular del programa de C\u00e0ncer Hereditari (ICO), ha rebut una de les Ajudes a la Investigaci\u00f3 de Neurofibromatosi de la Fundaci\u00f3 Proyecto Neurofibromatosis en la seva Convocat\u00f2ria 2018. L’ajuda, de 40.000\u20ac a repartir en dues anualitats, es destinar\u00e0 al desenvolupament del projecte “Recerca de ter\u00e0pies combinades per al tractament de tumors malignes de la beina nerviosa (MPNST)”.<\/p>\n
\u00a0<\/p>\n
\u00a0“Les ter\u00e0pies dirigides individuals no han demostrat efic\u00e0cia en el tractament de MPNST, probablement per l’heterogene\u00eftat del tumor del pacient, la manca de la interacci\u00f3 entre les c\u00e8l\u2022lules tumorals i estromals i el desenvolupament de resist\u00e8ncia a aquests tractaments”, explica la Dra. L\u00e1zaro . Per tot aix\u00f2, la combinaci\u00f3 de compostos ha sorgit com una estrat\u00e8gia per desenvolupar tractaments m\u00e9s efectius que abordin aquests tres problemes.<\/p>\n
\u00a0<\/p>\n
L’equip de la Dra. L\u00e1zaro ja ha realitzat un cribratge de f\u00e0rmacs d’alt rendiment en dues l\u00ednies cel\u2022lulars de MPNST, identificant medicaments potents i efica\u00e7os “que volem provar en diferents parells per trobar les millors sinergies”, afegeix la Dra. Juana Fern\u00e1ndez, investigadora postdoctoral associada al projecte. Amb el finan\u00e7ament rebut, els investigadors es proposen validar aquestes combinacions emprant una plataforma terap\u00e8utica per a la medicina de precisi\u00f3 in vitro \/ in vivo<\/em> ja desenvolupada que consta de tres components: l\u00ednies cel\u2022lulars MPNST, models de ratol\u00ed MPNST ortoxenograft (PDX) generats en col\u2022laboraci\u00f3 amb el Dr. Alberto Villanueva i un repositori de dades gen\u00f2miques de tots els models in vitro<\/em> i in vivo<\/em>.<\/p>\n \u00a0<\/p>\n \u00a0Amb tota aquesta informaci\u00f3, es busca establir models de predicci\u00f3 de resposta a f\u00e0rmacs, tant com a agents individuals com en combinaci\u00f3, comparar i avaluar de tractament en l\u00ednies cel\u2022lulars i models in vivo<\/em> provinents d’un mateix pacient, i estudiar l\u2019efecte de la senyalitzaci\u00f3 estromal en els tractaments i l’efectivitat de les combinacions terap\u00e8utiques sobre met\u00e0stasi. “En resum, ens proposem una avaluaci\u00f3 exhaustiva de diverses ter\u00e0pies combinades en la nostra plataforma terap\u00e8utica de MPNST per fer avan\u00e7ar el desenvolupament de ter\u00e0pies contra aquestes patologies”, conclou la Dra. L\u00e1zaro. El grup de la Dra\u00a0Conxi L\u00e1zaro, investigadora principal del grup de recerca en C\u00e0ncer hereditari del programa Oncobell (IDIBELL) i cap de la Unitat de diagn\u00f2stic molecular del programa de C\u00e0ncer Hereditari (ICO), ha rebut una de les Ajudes a la Investigaci\u00f3 de Neurofibromatosi de la Fundaci\u00f3 Proyecto Neurofibromatosis en la seva Convocat\u00f2ria 2018. L’ajuda, […]<\/p>\n","protected":false},"author":6,"featured_media":10588,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[332,417],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-12 19:45:16","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7658"}],"collection":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/comments?post=7658"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/posts\/7658\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media\/10588"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/media?parent=7658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/categories?post=7658"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/wp-json\/wp\/v2\/tags?post=7658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"